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|a 9780128171325
|q (electronic bk.)
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|a 0128171324
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|a 10.1016/S0070-2153(22)00056-4
|2 doi
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|a (OCoLC)1312240002
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|a RB125
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|a 616.02/7
|2 23
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|a Mouse models of development and disease /
|c edited by Thomas Gridley, Leif Oxburgh
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| 250 |
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|a First edition.
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| 264 |
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1 |
|a Cambridge, MA :
|b Elsevier Science & Technology,
|c 2022.
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| 300 |
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|a 1 online resource :
|b color illustrations
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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1 |
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|a Current topics in developmental biology,
|x 0070-2153 ;
|v volume 148
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| 504 |
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|a Includes bibliographical references.
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| 588 |
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|a Online resource.
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8 |
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|a 1.2. Wolffian and M|llerian ducts give rise to reproductive tract organs -- 1.3. Wolffian ducts are required for M|llerian duct formation -- 1.4. M|llerian duct fusion to the urogenital sinus and subsequent morphogenesis -- 1.5. Genes that regulate M|llerian duct formation -- 1.5.1. Transcription factors -- 1.5.2. Lhx1 -- 1.6. Secreted proteins -- 1.6.1. Wnt4 -- 1.7. Membrane-associated proteins -- 1.7.1. Greb1l -- 1.7.2. Lhfpl2 -- 1.7.3. Dlgh1 -- 1.8. Genes that regulate M|llerian duct differentiation -- 1.8.1. Wnt5a -- 1.8.2. Wnt7a -- 1.9. Human M|llerian duct development -- 1.10. Other mammalian uterine morphologies -- 1.10.1. Duplex uterus -- 1.10.2. Bipartite uterus -- 1.10.3. Bicornuate uterus -- 1.10.4. Simplex uterus -- 2. Human uterine variation -- 2.1. Prevalence of human uterine variation and correlation with miscarriage and infertility -- 2.2. M|llerian duct formation -- 2.3. M|llerian duct fusion -- 2.4. Uterine septal regression -- 3. Human uterine variation syndromes -- 3.1. Mayer-Rokitansky-K|ster-Hauser syndrome -- 3.2. Hand-foot-genital syndrome -- 3.3. Al-Awadi-Raas-Rothschild and Fuhrmann syndromes -- 3.4. Herlyn-Werner-W|nderlich syndrome -- 3.5. HNF1 homeobox B -- 4. Conclusion and final remarks -- References -- Chapter Four: Improving mouse models for the study of Alzheimer�s disease -- 1. Introduction -- 2. Overcoming limitations of existing mouse models relevant to early-onset AD -- 2.1. The limited translatability of familial AD models -- 2.2. Improving utility of familial/early-onset AD models -- 3. Developing mouse models of late-onset AD (LOAD) through the MODEL-AD consortium -- 3.1. Accelerating medicines partnerships: Alzheimer�s disease -- 3.2. Model organism development and evaluation for late onset Alzheimer�s disease (MODEL-AD) -- 4. Modeling vascular contributions.
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| 505 |
8 |
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|a 4.1. Emerging contribution of vascular dysfunction to AD -- 4.2. Vascular dysfunction in models of EOAD -- 4.3. Vascular dysfunction in genetic mouse models relevant to LOAD -- 4.4. Comorbidities that likely contribute to cerebrovascular decline in dementia -- 5. Minimizing species differences to model inflammatory contributions to AD -- 5.1. Humanizing immune-relevant processes in mouse models -- 5.2. Deciphering peripheral and central immune contributions using iPSC-derived microglia -- 6. Mouse models at single-cell or cell-state resolution -- 7. Integrating genetic context into mouse models to better represent the patient -- 8. Training resources for use of animal models of Alzheimer�s disease -- 9. Conclusions -- References -- Chapter Five: Mouse models for the study of clustered protocadherins -- 1. Introduction -- 1.1. Clustered protocadherins -- 1.2. The structure and binding specificity of cPcdhs -- 1.3. The evolution of the cPcdhs -- 2. Models to study isoform expression -- 3. Models to study function -- 3.1. Single cluster models -- 3.2. Multi-cluster models -- 3.3. Isoform specific models -- 3.4. Overexpression models -- 4. Future directions -- References -- Chapter Six: Wound healing and regeneration in spiny mice (Acomys cahirinus) -- 1. Introduction -- 2. Natural history and evolution of Acomys species -- 3. Acomys and the evolution of mammalian wound healing -- 4. Repair of skin wounds in Acomys -- 5. Repair of skeletal muscle injury in Acomys -- 6. Repair of kidney injury and regeneration of organ function in Acomys -- 7. Repair of cardiac injury in Acomys -- 8. Common features of Acomys regeneration studies -- 9. Summary -- Acknowledgments -- References -- Chapter Seven: Plumbing our organs: Lessons from vascular development to instruct lab generated tissues -- 1. Introduction -- 2. Vascular development: Basic step-wise processes.
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8 |
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|a 2.1. Vasculogenesis: De novo formation of vessels from angioblasts -- 2.2. Angiogenesis: Elaboration of new vessels from pre-existing ones -- 2.3. Necessity of flow for blood vessel differentiation and maintenance -- 2.4. Endothelial heterogeneity -- 2.5. Angiocrine signaling -- 3. Vascularization of the kidney -- 4. Organoid technology as a step toward organ replacement -- 4.1. Can organoids be properly vascularized? -- 5. Organoids and vascularization -- 6. The promise of vascular transcriptomes -- 7. Vascularization of organoids increases epithelial maturity -- 8. Methods for vascularization of organoids -- 8.1. Vascularization through addition of ECs -- 8.2. In vitro flow studies -- 8.3. Fluidics devices and other approaches to providing ECs with flow -- 8.4. Implantation of organoids to support and sustain organoid vasculature -- 8.5. Alternative pathways to promoting blood vessel maturation and maintenance -- 9. The challenges of organoid culture -- 10. Perspectives for the future of vascularized engineered tissues -- Acknowledgments -- Funding -- References -- Chapter Eight: Innervation in organogenesis -- 1. Introduction -- 2. Developmental origins of neurons -- 2.1. Neural crest cells -- 2.2. Sympathetic, sensory, and parasympathetic neuron formation from NCCs -- 2.3. Enteric NCCs -- 3. Neurotrophins and axon guidance cues -- 3.1. NGF, TrkA, and LNGFR/p75NTR -- 3.2. TrkB, TrkC, BDNF, and NT-3/4 -- 3.3. Neuronal guidance cues -- 4. Organ innervation and developmental roles -- 4.1. Lung -- 4.2. Gastrointestinal tract -- 4.3. Pancreas -- 4.4. Heart -- 4.5. Salivary gland -- 4.6. Urogenital system -- 4.7. Skeletal system -- 5. Discussion -- References -- Chapter Nine: Growth control of the kidney -- 1. Introduction -- 2. Kidney anatomy -- 3. Kidney development -- 4. Cessation of nephrogenesis -- 5. Nephron endowment.
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8 |
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|a 6. Insulin like growth factors in prenatal growth control -- 7. Growth hormone and insulin like growth factor in postnatal growth control -- 8. Reactivation of kidney growth in the adult -- 9. Perspectives -- Acknowledgments -- References.
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| 650 |
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0 |
|a Diseases
|x Animal models.
|
| 650 |
|
0 |
|a Animal models in research.
|
| 650 |
|
2 |
|a Disease Models, Animal
|0 (DNLM)D004195
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| 650 |
|
6 |
|a Maladies
|x Mod�eles animaux.
|0 (CaQQLa)201-0067878
|
| 650 |
|
6 |
|a Mod�eles animaux dans la recherche.
|0 (CaQQLa)201-0127335
|
| 650 |
|
7 |
|a Animal models in research
|2 fast
|0 (OCoLC)fst00809302
|
| 650 |
|
7 |
|a Diseases
|x Animal models
|2 fast
|0 (OCoLC)fst00895160
|
| 700 |
1 |
|
|a Gridley, Thomas,
|e editor.
|
| 700 |
1 |
|
|a Oxburgh, Leif,
|e editor.
|
| 830 |
|
0 |
|a Current topics in developmental biology ;
|v v. 148.
|x 0070-2153
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/00702153/148
|z Texto completo
|
