Combination drug delivery approach as an effective therapy for various diseases /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Kesharwani, Prashant
Formato: eBook
Idioma:Inglés
Publicado: London : Academic Press, 2022.
Temas:
Drug delivery systems.
Chemotherapy.
Drug Delivery Systems
Drug Therapy
Syst�emes d'administration de m�edicaments.
Chimioth�erapie.
Chemotherapy
Drug delivery systems
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Combination Drug Delivery Approach as an Effective Therapy for Various Diseases
  • Copyright Page
  • Dedication
  • Contents
  • List of contributors
  • Preface
  • Acknowledgments
  • A. Combination drug delivery approaches against various diseases
  • 1 Overcoming cancer drug resistance via nanomedicine-based combined drug delivery
  • 1.1 Introduction
  • 1.2 Organic nanocarriers
  • 1.2.1 Lipid-based systems
  • 1.2.1.1 Liposomal formulations
  • 1.2.1.2 Solid lipid nanoparticles
  • 1.2.1.3 Nanostructured lipid carriers
  • 1.2.1.4 Nanoemulsion
  • 1.2.2 Protein-based nanocarriers
  • 1.2.3 Polymeric nanoparticles
  • 1.3 Inorganic nanocarriers
  • 1.3.1 Iron oxide nanoparticles
  • 1.3.2 Quantum dots
  • 1.3.3 Gold nanoparticles
  • 1.3.4 Mesoporous silica nanoparticles
  • 1.3.5 Carbon-based nanocarriers
  • 1.3.5.1 Graphene
  • 1.3.5.2 Carbon nanotubes
  • 1.4 Conclusion
  • References
  • 2 Overcoming the challenges of drug resistance through combination drug delivery approach
  • 2.1 Introduction
  • 2.2 Drug resistance in cancer
  • 2.2.1 Intrinsic and acquired drug resistance
  • 2.2.2 Mechanisms of drug resistance
  • 2.2.2.1 Elevated drug efflux
  • 2.2.2.2 Tumor microenvironment
  • 2.2.2.3 Enhanced DNA repair
  • 2.2.2.4 Other mechanisms
  • 2.2.3 Combinational drug delivery systems in cancer drug resistance
  • 2.2.3.1 Nanoparticulate drug delivery systems
  • 2.2.4 Combinational therapies via nanoparticulate systems
  • 2.2.4.1 Combination of different chemotherapeutics
  • 2.2.4.2 Combination of chemotherapeutics and sensitizing agents
  • 2.2.4.2.1 P-gp inhibitors
  • 2.2.4.2.2 Autophagy inhibitors
  • 2.2.4.3 Combination of chemotherapeutics and genes
  • 2.2.4.3.1 Plasmid DNA
  • 2.2.4.3.2 RNAs
  • 2.2.4.4 Combination of chemotherapeutics and protein-based molecules
  • 2.2.4.4.1 Antibodies
  • 2.2.4.4.2 Peptides and proteins
  • 2.2.5 Conclusion
  • 2.3 Combination drug delivery approach to overcome antimicrobial resistance
  • 2.4 Conclusion
  • References
  • 3 Combination drug delivery approaches in ophthalmology
  • 3.1 The eye
  • 3.2 The need for new ophthalmic treatments
  • 3.2.1 Increasing prevalence of ocular diseases
  • 3.2.1.1 Age as risk factor
  • 3.2.1.2 Susceptibility to exogenous threats
  • 3.2.1.3 Refractive surgery for myopia
  • 3.2.2 The difficulty of drugs to reach their intraocular target
  • 3.2.3 Adverse ocular effects of topically administered drugs
  • 3.3 Drug-device combinations in ophthalmology
  • 3.3.1 Drug-device combinations for glaucoma
  • 3.3.2 Drug-device combinations for surgeries
  • 3.3.3 Drug-device combinations for ocular infections and inflammations
  • 3.3.4 Drug-device combinations for dry eye disease
  • 3.4 Challenges and future perspectives
  • References
  • 4 Combination drug delivery system to enhance the transdermal drug delivery of bioactive molecules
  • 4.1 Introduction
  • 4.2 Physiological skin row versus percutaneous permeation of bioactive molecules

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