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Torsades de pointes /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
2022.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Torsades de Pointes
- Copyright
- Dedication
- Contents
- Contributors
- Preface
- Chapter 1: Overview of torsades de pointes
- Introduction
- Definitions and descriptions of TdP
- Defining TdP
- ECG characteristics of TdP
- Historical perspectives
- Evolving understanding on mechanisms of TdP
- Pathophysiology of TdP
- Genesis of TdP
- Perpetuation of TdP
- Spotlight on: Canine models of TdP
- Overview of LQTS and TdP
- Relationship between LQTS and TdP
- Introduction to inherited and acquired QT interval prolongation
- Inherited QT interval prolongation
- Acquired QT interval prolongation
- Interplay of inherited and acquired factors in LQTS
- Epidemiology of TdP
- Overall rates of prolonged QTc interval and TdP
- Inherited LQTS and TdP
- Inherited LQTS
- Inherited TdP
- Acquired LQTS and TdP
- Acquired LQTS
- Acquired TdP
- Consequences of LQTS and TdP
- Symptoms of LQTS and TdP
- Spotlight on: Treatment of inherited LQTS
- Prognosis
- Prognosis in patients with inherited LQTS
- Prognosis in patients with acquired LQTS
- Future directions
- References
- Chapter 2: Torsades de pointes associated with inherited channelopathies
- Introduction
- Long QT syndrome
- Acquired LQTS and the link to congenital LQTS
- Torsades de pointes arrhythmias
- Therapeutic options for torsades de pointes
- Short-coupled torsades de pointes arrhythmia
- Therapeutic options for short-coupled torsades de pointes
- Conclusions
- References
- Chapter 3: Drug-induced torsades de pointes
- Introduction
- Medications as a cause of TdP
- Drug-induced QT interval prolongation and prediction of TdP risk
- Determining causality for drug-induced QT interval prolongation and TdP: The adverse drug event causality analysis (ADECA) ...
- Evidence requirements for risk categories
- Scientific validation of the QTdrugs list and the ADECA process
- Frequency of prescription of QT interval-prolonging medications
- Epidemiology of TdP and death associated with QT interval-prolonging drugs
- Management of risk of drug-induced QT prolongation and TdP
- Conclusion
- References
- Chapter 4: Mechanisms of torsades de pointes
- Introduction
- A brief introduction to ventricular action potential electrogenesis, including INa, IKs, and IKr
- Drugs linked to torsades de pointes in humans and the association with IKr/hERG block
- A role for pharmacological activation of late sodium current in diLQTS
- IKs and repolarization reserve
- Cellular arrhythmogenic events resulting from action potential prolongation: Early afterdepolarizations
- How is torsades de pointes initiated and maintained?
- Insights from genetically altered animal models of LQTS
- Insights into mechanisms of torsades de pointes from models used to study drug-induced long QT syndrome
- Constructing an integrated mechanistic description of torsades de pointes: Is there a final necessary mechanism?