Novel therapeutic approaches targeting oxidative stress /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Maurya, Pawan Kumar, Qamar, Imteyaz
Formato: eBook
Idioma:Inglés
Publicado: London : Academic Press, 2022.
Temas:
Oxidative stress > Treatment.
Oxidative stress > Diagnosis.
Stress oxydatif > Traitement.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Novel Therapeutic Approaches Targeting Oxidative Stress
  • Copyright
  • Dedication
  • Contents
  • Contributors
  • Preface
  • Acknowledgments
  • Chapter 1: Novel therapeutic approaches targeting oxidative stress in mood disorders
  • 1 Introduction
  • 2 The production of ROS in the brain
  • 3 The elimination of ROS in the brain
  • 4 Oxidative stress in the brain
  • 5 Markers of oxidative stress and mood disorders
  • 6 Antioxidant treatments in mood disorders
  • 6.1 Antioxidant action of conventional treatments for mood disorders
  • 6.2 Antioxidants as an add-on therapy in mood disorders
  • 6.2.1 N -acetylcysteine (NAC)
  • 6.2.2 Medications with some antioxidant action but not as the main mechanism of action
  • 6.3 Manipulation of oxidative stress through lifestyle interventions
  • 7 Conclusions
  • References
  • Chapter 2: Ferroptosis: Oxidative stress and pathophysiology
  • 1 Introduction
  • 2 Immunology
  • 3 Conclusion
  • Acknowledgment
  • Conflict of interest
  • References
  • Chapter 3: Oxidative stress and its biological significance
  • 1 Introduction
  • 2 Oxidative stress in 4-hydroxynonenal (HNE) leading to apoptosis
  • 3 Antioxidant supplementation increasing tumorigenesis
  • 3.1 Generation of mitochondrial ROS and cancer formation
  • 4 Regulation of the cell cycle in the oxidative state
  • 5 Viral infections and oxidative stress
  • 6 Epigenetic factors and carcinogenesis
  • 7 Extracellular superoxide angles and apoptosis
  • 7.1 HNE and its adducts in the regulation of transcription factors
  • 7.2 How oxidative DNA damage is critical to cancer
  • 7.3 Transcription factors that promote cancer
  • 7.4 Tumor-promoting genetic changes induce endogenous antioxidants
  • 7.5 Endogenous antioxidants promote cell migration and metastasis
  • 7.6 N -acetylcysteine-More than an antioxidant.
  • Chapter 4: Novel therapeutic approaches targeting oxidative stress in aging
  • 1 Introduction
  • 2 Hallmarks of aging
  • 3 Causes of aging
  • 4 Age-associated diseases
  • 4.1 Alzheimer's disease
  • 4.2 Cardiovascular disease
  • 4.3 Diabetes
  • 4.4 Cancer
  • 5 Novel therapeutic approaches
  • 5.1 Role of quercetin
  • 5.2 Role of curcumin
  • 5.3 Role of resveratrol
  • 6 Liposomes
  • 6.1 Charge on liposomes
  • 6.2 Role of liposomes in various diseases
  • 7 Conclusion
  • Acknowledgments
  • References
  • Chapter 5: Novel therapeutic approaches targeting oxidative stress in neurodegenerative diseases
  • 1 Introduction
  • 2 Dimensions of aging in the investigation of neurodegeneration
  • 2.1 Structural changes in Alzheimer's and Parkinson's disease
  • 2.2 Amyloid deposition
  • 2.3 Oxidative stress
  • 2.4 Immunosenescence
  • 2.5 Telomere shortening
  • 3 Clinical implications
  • 3.1 Antioxidants and antiaging agents' development as drugs
  • 3.2 Other pharmacological interventions
  • 3.3 Nonpharmacological interventions
  • 4 Implications for research
  • Acknowledgment
  • Conflicts of interest/competing interests
  • References
  • Chapter 6: The role of oxidative stress in kidney diseases
  • 1 Introduction
  • 2 Kidney architecture at the cellular level
  • 3 Nephrotoxicity and renal pathology
  • 3.1 Source of nephrotoxicity
  • 3.1.1 Therapeutic agents
  • 3.1.2 Environmental pollutants/toxins
  • 3.1.3 Diagnostic agents
  • 3.1.4 Alternative/health products
  • 4 Classification of kidney diseases
  • 4.1 Acute renal injury (ARI)
  • 4.2 Chronic kidney disease (CKD)
  • 5 The chemical species of oxidative stress
  • 5.1 Cellular mechanism for the formation of reactive oxygen species
  • 6 Cellular antioxidant defense system
  • 6.1 Superoxide dismutase (SOD)
  • 6.2 Glutathione peroxidase (GSHPX)
  • 7 Sources of ROS in the kidneys.
  • 7.1 NADPH oxidase as a source of ROS
  • 7.2 Mitochondrial ROS
  • 8 Reactive oxygen species and kidney diseases
  • 9 Oxidative stress in the renal tubules
  • 9.1 Proximal tubule
  • 9.2 Medulla
  • 9.3 Distal and collecting duct
  • 10 Oxidative stress in the glomerulus
  • 11 Oxidative stress in the renal vasculature
  • 12 Role of ROS in ischemia and reperfusion (I/R)-induced acute kidney injury
  • References
  • Chapter 7: The role of oxidative stress and antioxidants across the spectrum of acute coronary syndrome
  • 1 Introduction
  • 2 Oxidative stress
  • 3 Endothelial dysfunction and oxidative stress
  • 4 Molecular effects of oxidative stress
  • 5 Oxidative stress in coronary artery disease
  • 6 Coronary microvascular dysfunction
  • 7 Oxidative stress and lipids, protein, and DNA damage
  • 8 Therapies for oxidative stress-associated cardiovascular diseases
  • 8.1 Antioxidant molecules
  • 8.1.1 Nutritional supplements
  • 8.1.2 Novel experimental antioxidant-based therapies
  • 8.1.3 Antioxidant role of clinical drugs
  • 8.2 miRNAs
  • 8.3 Limitations
  • 9 Conclusions
  • References
  • Chapter 8: Biosensors in the detection of oxidative stress using discovered biomarkers
  • 1 Introduction
  • 2 Biosensors
  • 2.1 Working principle
  • 2.2 Types of biosensors
  • 2.2.1 Electrochemical biosensors
  • 2.2.2 Optical biosensors
  • 2.3 Other biosensors
  • 2.3.1 Piezoelectric biosensors
  • 2.3.2 Calorimetric biosensors
  • 2.3.3 Immuno-biosensors
  • 2.3.4 Nano biosensors
  • 2.3.5 Fluorescent biosensors
  • 2.3.6 Whole cell biosensors
  • 3 Biomarkers
  • 3.1 Genomic biomarkers
  • 3.2 Transcriptomic biomarkers
  • 3.3 Proteomic biomarkers
  • 3.4 Metabolomic biomarkers
  • 4 Overview of discovered biomarkers for oxidative stress
  • 5 Management of oxidative stress conditions
  • 5.1 Habits and lifestyle
  • 5.2 Food and beverage intake.
  • 5.3 Supplements and antioxidants
  • 5.4 Yoga, exercise, and meditation
  • 5.5 Healthcare situations and its management
  • 6 Research trends and future challenges in development of biosensors
  • 7 Conclusion
  • Acknowledgments
  • References
  • Chapter 9: Biochemical approaches/methods in the detection of free radicals
  • 1 Introduction
  • 2 In vitro methods
  • 3 Chemiluminescence-derived methods using luciferine derivatives
  • 4 Reduction of cytochrome c
  • 5 NBT tests
  • 6 Aconitase inactivation
  • 7 Boronates
  • 8 In vivo methods
  • 9 Redox potential of the GSH/GSSG couple
  • 10 Measurement of F2-isoprostanes as indicators of lipid per-oxidation
  • 11 Reporter assays
  • 12 Fluorescent protein-based methods
  • 13 Analytical methods
  • 14 Fluorescence-dependent methods
  • 15 Electron spin resonance (ESR) or electron paramagnetic resonance (EPR) spectroscopy
  • 16 Spin trapping technique
  • 17 Immuno-spin trapping of macromolecules
  • 18 Combined IST and mMRI detection
  • 19 Pulse radiolysis
  • 20 Chromatography-based techniques
  • 21 Other biochemical methods
  • 22 Summary
  • References
  • Chapter 10: Novel therapeutic approaches targeting oxidative stress in breast and lung cancer
  • 1 Introduction
  • 2 Epidemiology and risk factors
  • 2.1 Breast cancer epidemiology
  • 2.2 Lung cancer epidemiology
  • 3 Role of oxidative stress in cancer pathophysiology
  • 3.1 Tumor cellular proliferation and oxidative stress
  • 3.2 Metastasis and oxidative stress
  • 3.3 Oncogenes, tumor suppressor genes, and oxidative stress
  • 3.3.1 MicroRNAs regulated by ROS in cancer
  • 4 Classification of breast and lung cancer
  • 4.1 Breast cancer
  • 4.1.1 Noninvasive breast cancer (NIBC)
  • 4.1.2 Invasive breast cancer (IBC)
  • 4.1.3 Inflammatory breast cancer
  • 4.1.4 Paget's disease of the breast
  • 4.1.5 Phyllodes tumor.

Ejemplares similares