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|a Cellular and molecular aspects of myeloproliferative neoplasms.
|n Part B /
|c Edited by Niccol�o Bartalucci, Lorenzo Galluzzi.
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| 264 |
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1 |
|a [Place of publication not identified] :
|b Academic Press,
|c 2022.
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| 300 |
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|a 1 online resource.
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|a text
|2 rdacontent
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|a online resource
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|a International review of cell and molecular biology ;
|v 366
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| 505 |
0 |
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|a Intro -- Cellular and Molecular Aspects of Myeloproliferative Neoplasms -- Part B -- Copyright -- Contents -- Contributors -- Philadelphia-negative myeloproliferative neoplasms: From origins to new perspectives -- Acknowledgments -- Conflict of Interest -- References -- Chapter One: The roles of sex and genetics in the MPN -- 1. Introduction -- 2. Sex as a factor in MPN epidemiology -- 3. Biologic basis of sex differences in somatic mutation burden -- 4. Genetic predisposition to CH and the MPN -- 5. Heritable risk factors for CH and MPN
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| 505 |
8 |
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|a 5.1. Familial MPN and myeloid malignancy predisposition syndromes -- 5.2. GWAS identified risk alleles in the general population -- 6. Inflammation as a risk for CH and MPN -- 7. Mutation burden and clinical risk -- 8. Conclusion -- Funding -- Conflicts of interest -- References -- Chapter Two: Transcriptional configurations of myeloproliferative neoplasms -- 1. Introduction -- 2. Studies on the bulk transcriptome of MPN patients -- 3. From bulk to single cell transcriptomic sequencing of MPN patients -- 4. Analysis of splicing abnormalities with RNA-seq
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| 505 |
8 |
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|a 5. Analysis of fusion genes in MPN and post-MPN AML patients -- 6. Concluding remarks and future directions -- References -- Chapter Three: Targets in MPNs and potential therapeutics -- 1. Introduction -- 2. JAK2 mutations -- 2.1. Behind JAK2V617F: The molecular background -- 2.2. JAK2V617F inhibition strategies -- 2.3. Other JAK inhibitors in MF -- 2.4. Concerns emerging from JAK2 inhibition in myelofibrosis -- 3. TPOR/MPL inhibition strategies -- 4. CALR mutations -- 4.1. CALR inhibition strategies -- 4.2. Potential therapies targeting CALR mutants -- 5. Other targeted therapies
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| 505 |
8 |
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|a 3. Driver mutations and beyond in MPN and leukemic transformation -- 3.1. Driver mutations -- 3.2. Non-driver mutations -- 3.3. Clonal evolution of MPN-BP -- 3.4. Mutations affecting signal transduction and transcription regulators -- 3.5. Mutations in epigenetic regulators -- 3.5.1. Preclinical and clinical studies on combinations targeting epigenetic modifiers -- 3.6. Mutations in RNA splicing factors -- 4. Conclusions -- Acknowledgments -- Disclosures -- References -- Chapter Five: Lessons from mouse models of MPN -- 1. ``Of mice and Me��n
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| 650 |
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0 |
|a Bone marrow
|x Diseases
|x Molecular aspects.
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| 650 |
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0 |
|a Bone marrow
|x Diseases
|x Cytology.
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| 650 |
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6 |
|a Moelle osseuse
|0 (CaQQLa)201-0015076
|x Maladies
|0 (CaQQLa)201-0015076
|x Aspect mol�eculaire.
|0 (CaQQLa)201-0374959
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| 650 |
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6 |
|a Moelle osseuse
|0 (CaQQLa)201-0015076
|x Maladies
|0 (CaQQLa)201-0015076
|x Cytologie.
|0 (CaQQLa)201-0379624
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| 700 |
1 |
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|a Bartalucci, Niccol�o.
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| 700 |
1 |
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|a Galluzzi, Lorenzo.
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| 776 |
0 |
8 |
|c Original
|z 0323899412
|z 9780323899413
|w (OCoLC)1285579695
|
| 830 |
|
0 |
|a International review of cell and molecular biology ;
|v 366.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/19376448/366
|z Texto completo
|
