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RAS : past, present, and future /
| Clasificación: | Libro Electrónico |
|---|---|
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press,
2022.
|
| Colección: | Advances in cancer research ;
v. 153. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1. A brief history of RAS and the RAS Initiative; Frank McCormick ; 2. Not all RAS mutations are equal: A detailed review of the functional diversity of RAS hot spot mutations; Rachel A. Burge and G. Aaron Hobbs ; 3. Drug targeting opportunities en route to Ras nanoclusters; Karolina Pavic, Rohan Chippalkatti, and Daniel Abankwa ; 4. Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer; J. Nathaniel Diehl, Priya S. Hibshman, Irem Ozkan-Dagliyan, Craig M. Goodwin, Sarah V. Howard, Adrienne D. Cox, and Channing J. Der ; 5. Pan-RAS inhibitors: Hitting multiple RAS isozymes with one stone; Alexander B. Coley, Antonio Ward, Adam B. Keeton, Xi Chen, Yulia Maxuitenko, Aishwarya Prakash, Feng Li, Jeremy B. Foote, Donald J. Buchsbaum, and Gary A. Piazza ; 6. Targeting RAS oncogenesis with SOS1 inhibitors; Roman Christian Hillig and Benjamin Bader ; 7. Inhibition of SHP2 as an approach to block RAS-driven cancers; Yu-Ting Chou and Trever G. Bivona ; 8. Targeting the "undruggable#x94; RAS with biologics; Michael Whaby, Imran Khan, and John P. O'Bryan ; 9. Unraveling and targeting RAS-driven metabolic signaling for therapeutic gain; Jonathan M. DeLiberty, Ryan Robb, Claire E. Gates, and Kirsten L. Bryant ; 10. The RASopathies: Biology, genetics and therapeutic options; Jody Fromm Longo and Steven L. Carroll