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20231120010621.0 |
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|a 1286705393
|a 1286794558
|a 1286927157
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|a (OCoLC)1286954501
|z (OCoLC)1286705393
|z (OCoLC)1286794558
|z (OCoLC)1286927157
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|a RB113
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|a 616.07
|2 23
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| 245 |
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|a Cellular senescence in disease /
|c edited by Manuel Serrano, Daniel Mu�noz-Esp�in.
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| 260 |
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|a London :
|b Academic Press,
|c 2022.
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| 300 |
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
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|a Front Cover -- Cellular Senescence in Disease -- Cellular Senescence in Disease -- Copyright -- Contents -- Contributors -- Foreword -- REFERENCES -- 1 -- Fundamentals -- 1 -- Cellular senescence: from old to new testament -- Old testament-genesis of senescence -- New testament-from mechanisms and roles of senescence to therapies -- Replicative senescence and telomeres -- Oncogene-induced senescence and tumor suppression -- Damage-induced senescence -- Hallmarks of cellular senescence -- SASP -- Senescence in physiology, repair, and embryonic development -- Senescence in aging and age-related disorders -- Prosenescent and antisenescent therapies -- Clinical trials -- References -- 2 -- Cellular senescence in disease states -- 2 -- Premalignant lesions and cellular senescence -- Introduction -- Cellular senescence in premalignant lesions: evidence in various organs -- Skin -- Head and neck -- Lungs -- Gastrointestinal tract -- Liver -- Pancreas -- Mammary gland -- Prostate gland -- Cervix -- Thyroid -- Future perspectives -- References -- Further reading -- 3 -- Lung aging and senescence in health and disease -- Introduction -- Normal lung development and aging -- A brief introduction to COPD and IPF -- Abnormal hallmarks of lung aging in COPD and IPF -- Cellular senescence -- Mitochondrial dysfunction -- Stem cell dysfunction -- Telomere dysfunction -- Epigenetic changes and miRNAs -- Loss of protein homeostasis (proteostasis) -- Deregulated nutrient sensing -- Extracellular matrix (ECM) dysregulation -- Future treatment targeting lung senescence -- Conclusions -- Supported -- Abbreviations -- References -- 4 -- Cell senescence in pulmonary hypertension -- Introduction -- Pulmonary hypertension, a non-aging-related proliferative vascular disorder at the crossroads of vascular disease and cancer.
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| 505 |
8 |
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|a General considerations about aging of the systemic and pulmonary vascular systems -- Considerations about constitutive cells of pulmonary vessels and the specificity of the pulmonary vasculature -- Potential mechanisms accounting for cell senescence in PH and PAH -- DNA damage is associated with PH -- Pulmonary artery smooth muscle cells (PASMCs) -- Pulmonary vascular endothelial cells (PECs) -- Genetic and environmental factors responsible for DNA damage in PAH -- The link between DNA damage, cell senescence, and PAH pathogenesis -- Alteration in the BMPR2/TGF beta pathway -- Hypoxia -- Drugs -- Telomere dysfunction -- Shear stress -- HIV infection -- Role for senescent cells in PH and PAH -- General considerations -- Induction of lung cell senescence: effect on PH -- Treatment with nutlin -- Telomerase inactivation -- Induction of cell senescence by activation of signaling pathways involved in chronic lung diseases -- Prevention or protection against lung cell senescence: effect on PH -- Inactivation of p53, p21, p16 -- Elimination of senescent cells in experimental PAH -- Conclusion -- References -- 5 -- Liver diseases fibrosis and cirrhosis -- Liver structure and function -- Cellular senescence -- Liver diseases-epidemiology and clinical aspects -- Senescence during aging of the healthy liver -- Senescence in acute liver injury -- Senescence in chronic liver disease -- Role of senescence in hepatic dysfunction -- Evolutionary role of senescence in the liver -- Senescence during hepatic carcinogenesis -- Summary and closing comments -- References -- 6 -- Cellular senescence during aging and chronic liver diseases: mechanisms and therapeutic opportunities -- Introduction -- Cellular senescence in the liver -- Mechanisms contributing to cellular senescence in liver -- Telomere dysfunction -- Autophagy impairment -- Mitochondrial dysfunction.
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|a Fatty acids -- Oxidative stress -- Telomere shortening -- Growth hormone axis -- mTOR activity -- Altered microbiome -- Threshold theory of senescent cell burden -- Implications of senescence in obesity: downstream effects -- Inflammation -- Inhibition of adipogenesis and ectopic lipid deposition -- NAD+ depletion due to CD38+ macrophage attraction -- Obesity-induced neurocognitive defects -- Paracrine effects on neighboring cells -- Promotion of cancer development -- Reduced regenerative potential -- Strategies to target obesity-related senescent cells -- Exercise and weight loss -- Senolytics -- SASP inhibitors or senomorphics -- Administration schedule of senescence-targeting therapies -- References -- 12 -- A framework for addressing senescent cell burden in the osteoarthritic knee: therapeutics, immune signaling, a ... -- Introduction -- Main -- Knee tissues degenerate in osteoarthritis -- Chronic presence of senescent cells in the knee accelerates osteoarthritic erosion -- Killing senescent cells in the knee can reduce OA-associated dysfunction -- Translating antisenescent therapies to the clinic for OA treatment -- Conclusion -- Competing interests -- References -- 13 -- Osteoporosis and bone loss -- Osteoporosis as a public health problem -- The hallmarks of aging in bone -- The role of cellular senescence in mediating age-related bone loss -- Identification of senescent cells in the bone microenvironment -- Causal role for cellular senescence in mediating age-related bone loss -- Role of cellular senescence in mediating age-related frailty -- Estrogen deficiency and cellular senescence -- The role of cellular senescence in the effects of diabetes mellitus on bone -- Cellular senescence and radiation- and chemotherapy-induced bone loss.
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| 650 |
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0 |
|a Pathology, Cellular.
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| 650 |
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0 |
|a Age factors in disease.
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| 650 |
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0 |
|a Cells
|x Aging.
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| 650 |
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2 |
|a Age Factors
|0 (DNLM)D000367
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| 650 |
|
2 |
|a Cellular Senescence
|0 (DNLM)D016922
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| 650 |
|
6 |
|a Cytopathologie.
|0 (CaQQLa)201-0043807
|
| 650 |
|
6 |
|a Maladies
|x Facteurs li�es �a l'�age.
|0 (CaQQLa)201-0000226
|
| 650 |
|
6 |
|a Cellules
|x Vieillissement.
|0 (CaQQLa)201-0317869
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| 650 |
|
7 |
|a Age factors in disease
|2 fast
|0 (OCoLC)fst00800172
|
| 650 |
|
7 |
|a Cells
|x Aging
|2 fast
|0 (OCoLC)fst00850252
|
| 650 |
|
7 |
|a Pathology, Cellular
|2 fast
|0 (OCoLC)fst01054974
|
| 700 |
1 |
|
|a Serrano, Manuel.
|
| 700 |
1 |
|
|a Mu�noz-Espin, Daniel.
|
| 776 |
0 |
8 |
|i Print version:
|z 0128225149
|z 9780128225141
|w (OCoLC)1237632171
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128225141
|z Texto completo
|
