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Current progress in iPSC disease modeling /
Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation...
| Call Number: | Libro Electrónico |
|---|---|
| Other Authors: | |
| Format: | Electronic eBook |
| Language: | Inglés |
| Published: |
London :
Academic Press,
[2022]
|
| Series: | Advances in stem cell biology ;
v. 14. |
| Subjects: | |
| Online Access: | Texto completo |
Table of Contents:
- Front Cover
- Current Progress in iPSC Disease Modeling, Volume 14
- Advances in Stem Cell Biology
- Current Progress in iPSC Disease Modeling, Volume 14
- Copyright
- Dedication
- Contents
- Contributors
- About the editor
- Alexander Birbrair
- Preface
- 1
- Human induced pluripotent stem cell modeling of neurofibromatosis type 1
- Introduction
- NF1 gene
- Genotype-phenotype correlations
- Roadblocks to treatment
- Nf1 genetically engineered mouse models
- Utility of human induced pluripotent stem cells for NF1 research
- Brain development and function
- Mutational specificity
- Cell-autonomous effects
- Modeling brain development and function
- Nervous system tumors
- Tumor modeling
- Tumor microenvironment
- Other NF1 clinical features
- Future directions
- References
- 2
- Use of induced pluripotent stem cells to model inflammatory neurodegeneration and repair in multiple sclerosis
- Introduction
- Multiple sclerosis background
- Utility of animal models to study stem cells in multiple sclerosis
- Modeling neurological diseases using stem cells
- Modeling multiple sclerosis with human-derived induced pluripotent stem cells
- Challenges in the field
- Future Directions
- Conclusions
- References
- 3
- Induced pluripotent stem cell technology to model chronic mountain sickness
- Introduction
- Induced pluripotent stem cell-derived in-vitro erythroid system to study hypoxia-induced excessive erythropoiesis in chroni ...
- Induced pluripotent stem cell-derived neural cells to study neuropathology in chronic mountain sickness
- Induced pluripotent stem cell-derived neural cells to study ionic homeostasis in chronic mountain sickness
- Summary and future directions
- References
- 4
- Induced pluripotent stem cells for modeling Noonan, Noonan Syndrome with Multiple Lentigines, and Costello Synd .
- Glossary of terms
- Preface
- Induced pluripotent stem cells and CRISPR-Cas9
- RASopathies and signaling
- Noonan syndrome
- Disease modeling of Noonan syndrome
- Delineating Noonan syndrome-associated cardiac hypertrophy using induced pluripotent stem cell technology
- Understanding cancer causing Noonan syndrome mutations using induced pluripotent stem cells
- Noonan Syndrome with Multiple Lentigines
- Disease modeling of Noonan Syndrome with Multiple Lentigines
- Delineating Noonan Syndrome with Multiple Lentigines-associated cardiac hypertrophy using induced pluripotent stem cell tec ...
- Costello Syndrome
- Costello Syndrome and HRAS
- Disease modeling of Costello Syndrome
- Costello Syndrome and induced pluripotent stem cells
- Limitations and future direction of induced pluripotent stem cell model systems
- RASopathies and induced pluripotent stem cells: where do we go from here?
- Conclusions
- References
- 5
- Modeling mitochondrial encephalopathy due to MELAS/Leigh overlap syndrome using induced pluripotent stem cells
- Mitochondrial disease
- Heteroplasmy and threshold effect
- Neurological manifestations
- Mitochondrial dysfunction and induced pluripotent stem cells
- Role of mitochondria in reprogramming
- Role of mitochondria in maintenance and proliferation of induced pluripotent stem cells
- Role of mitochondria in differentiation from induced pluripotent stem cells
- Future trends
- References
- 6
- How induced pluripotent stem cells changed the research status of polycystic ovary syndrome
- Introduction to stem cells and embryonic stem cells
- The development of somatic reprogramming
- Nuclear transfer technique
- Cell fusion technique
- Induced pluripotent stem cells
- Pathological features of polycystic ovary syndrome
- Progress in polycystic ovary syndrome treatment and research.
- Research on polycystic ovary syndrome
- Methylation
- Histone modification
- Genomic imprinting
- Long noncoding RNA and microRNA
- Treatments for polycystic ovary syndrome
- Application of induced pluripotent stem cells in polycystic ovary syndrome disease research
- The application of induced pluripotent stem cells
- The induced pluripotent stem cell disease model of polycystic ovary syndrome
- References
- 7
- Modeling inherited retinal dystrophies using induced pluripotent stem cells
- Introduction
- Retina: architecture and function
- Retinal degeneration: inherited retinal dystrophy
- Stem cells
- Embryonic and induced pluripotent stem cells
- Methods of obtaining induced pluripotent stem cell
- Disease modeling
- Clinical assessment of inherited retinal dystrophies
- Inherited retinal dystrophy research using patient tissue or animal models
- Pluripotent stem cell differentiation into retinal cell types
- Retinal pigment epithelium
- Neural retina: organoid systems
- Neural retina: photoreceptors
- Induced pluripotent stem cell disease models of inherited retinal dystrophies
- Retinitis pigmentosa
- Leber congenital amaurosis
- Choroideremia
- Bestrophinopathy (best disease)
- Stargardt maculopathy
- Conclusion and caveats
- References
- 8
- Modeling hereditary spastic paraplegias using induced pluripotent stem cells
- Introduction
- Cellular pathogenic themes in hereditary spastic paraplegia
- Membrane modeling and shaping
- Vesicular transport along axons
- Impairment in lipid/sterol metabolism
- Endolysosomal and autophagic dysfunction
- Modeling different types of hereditary spastic paraplegia using induced pluripotent stem cells
- Autosomal dominant hereditary spastic paraplegia
- SPG4
- SPG3A
- Autosomal recessive hereditary spastic paraplegia
- SPG5
- SPG11, SPG15, and SPG48.
- Other types of hereditary spastic paraplegia
- Challenges and future directions
- Heterogeneity and functional maturation of induced pluripotent stem cell-derived neurons
- Recapitulation of synaptic and circuitry defects
- Interplay of multiple pathogenic mechanisms
- Identification of therapeutic approaches
- References
- 9
- Induced pluripotent stem cells for modeling Smith-Magenis syndrome
- Introduction
- The genetics of Smith-Magenis syndrome
- Diagnostic test
- Clinical presentation of Smith-Magenis syndrome
- Disease onset, diagnosis, and symptomatology
- Brain structural abnormalities
- Behavioral, neurodevelopmental, and cognitive aspects
- Sleepwake cycle dysfunction
- Eating disorders, auxologic and nutritional issues
- Craniofacial features, skeletal and hearing system impairment
- Dermatological symptoms
- Congenital defects
- Retinoic acid-induced 1: from gene to protein
- The Retinoic acid-induced 1 gene
- Rai1 expression and subcellular localization
- Correlation between structure and function
- Rai1 function
- Model systems of Smith-Magenis syndrome
- Animal models of Smith-Magenis syndrome
- Cellular models: Smith-Magenis syndrome patient-derived primary cell lines
- Induced pluripotent stem cells for modeling Smith-Magenis syndrome
- Organoids and neurospheres
- Concluding remarks
- References
- 10
- Induced pluripotent stem cells for modeling of cardiac arrhythmias
- Introduction
- The use of human induced pluripotent stem cells-derived cardiomyocytes to investigate inherited arrhythmias
- Long QT syndrome
- Short QT syndrome
- Brugada syndrome
- Catecholaminergic polymorphic ventricular tachycardia
- Atrial fibrillation
- Application of human induced pluripotent stem cells-derived cardiomyocytes to investigate acquired arrhythmias
- Infection-induced arrhythmia.
- Hormone-induced arrhythmia
- Drug-induced arrhythmia
- Limitations
- Conclusion and perspective
- Funding
- References
- 11
- Modeling heritable kidney disease using human kidney iPSC-derived organoids
- Introduction
- Kidney organoids are accurate models of the developing kidney
- Genetic diseases of the glomerulus
- Kidney organoids for the study of glomerular disease
- Inherited diseases of the renal tubule
- Kidney organoids and the study of tubular disease
- Strengths and limitations of kidney organoids as models of inherited kidney disease compared to existing animal and two-dim ...
- Conclusions
- References
- Further reading
- Index
- A
- B
- C
- D
- E
- F
- G
- H
- I
- J
- K
- L
- M
- N
- O
- P
- R
- S
- T
- U
- V
- W
- X
- Back Cover.