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Haschek and Rousseaux's handbook of toxicologic pathology. Volume I, Principles and practice of toxicologic pathology /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Haschek, Wanda M. (Editor ), Rousseaux, Colin George, 1954- (Editor ), Wallig, Matthew A. (Editor ), Bolon, Brad (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Elsevier/Academic Press, [2022]
Edición:Fourth edition.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Toxicologic pathology: an introduction
  • Biochemical and molecular basis of toxicity
  • ADME principles in small molecule drug discovery and development: an industrial perspective
  • Biotherapeutics ADME and PK/PD principles
  • Principles of pharmacodynamics and toxicodynamics
  • The role of pathology in evaluation of reproductive, developmental, and juvenile toxicity
  • Carcinogenesis: mechanisms and evaluation
  • Basic approaches in anatomic toxicologic pathology
  • Clinical pathology in nonclinical toxicity testing
  • Special techniques in toxicologic pathology
  • Digital pathology and tissue image analysis
  • In vivo small animal imaging: a comparison to gross and histopathologic observations in animal models
  • Biomarkers: discovery, qualification, and application
  • Toxicogenomics: a primer for toxicologic pathologists
  • Experimental design and statistical analysis for toxicologic pathologists
  • Animal models in toxicologic research: rodents
  • Animal models in toxicologic research: rabbit
  • Animal models in toxicologic research: dog
  • Animal models in toxicologic research: pig
  • Animal models in toxicologic research: nonhuman primate
  • Animal models in toxicologic research: nonmammalian
  • Genetically engineered animal models in toxicologic research
  • Alternative models in biomedical research: in silico, in vitro, ex vivo, and nontraditional in vivo approaches
  • Nomenclature and diagnostic resources in anatomic toxicologic pathology
  • Pathology peer review
  • Pathology and GLPs, quality control, and quality assurance
  • Practices to optimize generation, interpretation, and reporting of pathology data from toxicity studies
  • Issues in laboratory animal science that impact toxicologic pathology.