Effects of peri-adolescent licit and illicit drug use on the developing CNS. Part I /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bell, Richard L., 1961-, Rahman, Shafiqur, 1963-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2021.
Colección:International review of neurobiology ; v. 160.
Temas:
Neuropharmacology.
Teenagers > Drug use.
Neuropharmacology
Neuropharmacologie.
Teenagers > Drug use
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Peri-adolescent addiction as a public health issue
  • Neurodevelopment during adolescence and emerging adulthood
  • Adolescent timing in rodents
  • The addiction cycle
  • Learning and memory
  • Chapters in Part I of the special issue
  • References
  • Chapter One: The persistent impact of adolescent binge alcohol on adult brain structural, cellular, and behavioral pathol ...
  • 1. Introduction
  • 1.1. Alcohol use in human adolescents increases risk for developing an alcohol use disorder in adulthood
  • 1.2. Adolescent intermittent ethanol (AIE) exposure increases adult drinking
  • 2. Brain maturation during adolescence creates a window of vulnerability for injury
  • 2.1. Adolescent maturation of neurocircuitry
  • 2.2. Adolescent maturation of brain glia
  • 3. Persistent changes in adult brain after adolescent binge alcohol
  • 3.1. Long-lasting changes in MRI-assessed structure
  • 3.2. Cellular changes in brain after adolescent binge drinking
  • 3.3. Loss of adult neurogenesis
  • 3.4. Lasting changes in adult brain gene expression
  • 3.5. Adolescent alcohol exposure-induced changes in adult behavior
  • 4. Neuroimmune signaling and epigenetic mechanisms
  • 4.1. Microglial memory
  • 4.2. Microglia, intoxication, and priming during withdrawal
  • 4.3. Neuronal and glial neuroimmune signaling
  • 4.4. Immune signaling and histone modifications with transcriptional silencers and enhancers
  • 4.5. Epigenetic cholinergic neuronal phenotype loss and trophic-proinflammatory balance
  • 5. Reversibility of persistent adolescent alcohol pathology: Exercise, anti-inflammatories, and promotion of cholinergic ...
  • 6. Adolescent alcohol abuse as a possible risk factor for cognitive decline with aging
  • 7. Conclusion
  • References
  • Chapter Two: Neuroepigenetic consequences of adolescent ethanol exposure
  • 1. Introduction
  • 2. Epigenetic modifications
  • 3. Ethanol�s metabolic influence on epigenetics
  • 4. Ethanol-induced epigenetic alterations in the amygdala
  • 5. Ethanol-induced epigenetic alterations in the prefrontal cortex
  • 6. Ethanol-induced epigenetic alterations in the hippocampus
  • 7. Conclusion and future directions
  • Acknowledgments
  • References
  • Chapter Three: Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use dur ...
  • 1. Epidemiology of alcohol use in adolescence
  • 2. Overview of factors associated with alcohol misuse in adolescence
  • 3. Alcohol use during adolescence: Its effect on brain structure and function
  • 3.1. Brain structural disturbance
  • 3.2. Brain functional impairments
  • 3.3. Short conclusion
  • 4. Resilience and brain mechanisms

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