Translational autoimmunity : etiology of autoimmune diseases /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Rezaei, Nima (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, [2022]
Colección:Translational Immunology ; 1
Temas:
Autoimmunity.
Immunology.
Autoimmunity
Allergy and Immunology
Auto-immunit�e.
Immunologie.
Immunology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Translational Autoimmunity, Vol. 1: Etiology of Autoimmune Diseases
  • Copyright
  • Dedication
  • Contents
  • Contributors
  • Preface
  • Series editor biography
  • Acknowledgment
  • Abbreviations
  • Chapter 1 Introduction on translational autoimmunity: From bench to bedside
  • 1 Introduction
  • 2 Autoimmune disorders
  • 3 Pathogenesis and mechanisms of autoimmune diseases
  • 4 Predisposing factors
  • 5 Role of genetics
  • 6 Obstacles in treatment
  • 7 Diagnostic tools
  • 8 Role of innate immunity
  • 9 Conclusion
  • References
  • Chapter 2 Autophagy in autoimmunity
  • 1 Introduction
  • 2 An overview of autophagy
  • 3 Autophagy in immunity
  • 3.1 Autophagy in innate immunity
  • 3.1.1 Elimination of pathogens by autophagy
  • 3.1.2 Autophagy in inflammation regulation
  • 3.2 Autophagy in adaptive immunity
  • 3.2.1 Antigen presentation
  • 3.2.2 Lymphocyte differentiation and survival
  • Autophagy in T cells
  • Autophagy in B cells
  • 4 Autophagy in autoimmune diseases
  • 4.1 Autophagy in SLE
  • 4.2 Autophagy in RA
  • 4.3 Autophagy in MS
  • 4.4 Autophagy in AIH
  • 5 Conclusion
  • Acknowledgments
  • Conflict of interest
  • References
  • Chapter 3 Immunometabolism and autoimmunity
  • 1 Introduction
  • 2 Immunometabolism in homeostasis
  • 2.1 T cell metabolism
  • 2.2 B cell metabolism
  • 2.3 Macrophage metabolism
  • 3 Immunometabolism in autoimmunity
  • 3.1 SLE
  • 3.2 RA
  • 3.3 MS
  • 3.4 Autoinflammatory diseases
  • 4 Conclusion
  • References
  • Chapter 4 T cell recognition of neoepitopes in autoimmunity
  • 1 Introduction
  • 2 The mystery of lost tolerance in autoimmunity
  • 3 Determinant spreading in autoimmune disease
  • 4 Neoepitopes as a challenge to immune tolerance
  • 4.1 Autoimmune susceptible HLA enhance presentation of neoepitope peptides
  • 4.2 Increased TCR recognition of neoepitope peptides.
  • 5 T cell recognition of citrullinated neoepitopes in rheumatoid arthritis
  • 6 T cell recognition of deamidated neoepitopes in CD
  • 7 T cell recognition of neo-antigens in T1D
  • 7.1 Cellular stress and upregulation of modifying enzymes
  • 7.2 Cellular stress and alteration of the encoded proteome of target cells
  • 8 Prospects for diagnostic detection of neoepitope specific T cell responses
  • 9 Conclusion
  • References
  • Chapter 5 Role of Th1 and Th2 in autoimmunity
  • 1 Introduction
  • 1.1 Lymphocytes development, maturation, and "central tolerance"
  • 1.2 Lymphocytes migration in the body and "peripheral tolerance"
  • 1.3 Lymphocytes roles and plasticity: The Th1/Th2 hypothesis
  • 2 Th1 and Th2 generation
  • 2.1 Th1 polarization
  • 2.2 Th2 polarization
  • 3 Th1 and Th2 response in health
  • 3.1 Th1 response
  • 3.2 Th2 response
  • 4 Breakdown of tolerance: Autoimmunity and allergy
  • 4.1 Th1 in disease
  • 4.2 Th2 in disease
  • 5 Conclusion
  • References
  • Chapter 6 Role of Th17 cell in tissue inflammation and organ-specific autoimmunity
  • 1 Introduction
  • 2 Differentiation of IL-17-producing Th17 cells
  • 3 Amplification of Th17 cells
  • 4 Stabilization of Th17 cells
  • 5 Transcriptional regulation of Th17 cells
  • 6 Regulators of Th17 cells
  • 6.1 IL-27 and Th17 cells
  • 6.2 IL-10 and Th17 cells
  • 6.3 IL-2 and Th17 cells
  • 6.4 IL-25 and Th17 cells
  • 6.5 STATS as a negative regulator of Th17 cells
  • 7 Small molecules inhibitor of Th17 cells
  • 8 Role of Th17 cells in the pathogenesis of autoimmune diseases
  • 8.1 Alopecia areata
  • 8.2 Systemic lupus erythematosus
  • 8.3 Type 1 diabetes mellitus
  • 8.4 S�jgren syndrome
  • 8.5 Periodontitis and oral lichen planus
  • 8.6 Autoimmune thyroid disorders
  • 8.7 Noninfectious uveitis
  • 8.8 Myasthenia gravis
  • 8.9 Ankylosing spondylitis
  • 8.10 Juvenile idiopathic arthritis.
  • 8.11 Systemic sclerosis
  • 8.12 Psoriasis
  • 8.13 Inflammatory bowel disease
  • 8.14 Multiple sclerosis
  • 8.15 Rheumatoid arthritis
  • 9 Conclusion
  • Acknowledgments
  • References
  • Chapter 7 Peptide editing and its modulation in CD4 + T cell tolerance to self
  • 1 Introduction
  • 2 Cellular adaptive immunity in health and disease
  • 2.1 Basics of CD4 + T cell responses
  • 2.2 HLA genes and proteins, and their link to autoimmunity
  • 2.3 Basics of HLAII antigen presentation and the relevance of peptide editing
  • 2.4 Peptide editing in different antigen presenting cells
  • 2.5 Recognition of pMHCII by the TCR: The key step towards T cell activation
  • 3 Tolerance mechanisms: training lymphocytes for a proper self and non-self recognition
  • 3.1 Central tolerance
  • 3.1.1 Positive selection
  • 3.1.2 Negative selection or clonal deletion
  • 3.1.3 Treg selection in the thymus
  • 3.2 Peripheral tolerance
  • 3.2.1 Ignorance
  • 3.2.2 Anergy
  • 3.2.3 Clonal deletion, peripheral Treg conversion and suppressor function
  • 3.3 Peptide editing in the context of the affinity and avidity models for T cell activation and tolerance acquisition
  • 4 Peptide editing in the targets of organ-specific autoimmune diseases
  • 5 Conclusion
  • References
  • Chapter 8 Innate lymphoid cells in autoimmune diseases
  • 1 Introduction
  • 2 ILCs as crucial components of the mammalian immune system
  • 2.1 Group 1 ILCs or ILC1s as potential innate immune lymphoid cells
  • 2.2 Group 2 ILCs or ILC2s in immunity and inflammation
  • 2.3 Group 3 ILCs or ILC3s in immunity and inflammation
  • 3 ILCs in ADs
  • 3.1 Group 1 ILCs or ILC1s in ADs
  • 3.2 Group 2 ILCs or ILC2s in ADs
  • 3.3 Group 3 ILCs or ILC3s in ADs
  • 4 Conclusion
  • References
  • Chapter 9 Autoimmune diseases and the role of Toll-like receptor-7 and -9 signaling cascades
  • 1 Introduction
  • 2 Toll-like receptors.

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