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|a Translational autoimmunity :
|b etiology of autoimmune diseases /
|c edited by Nima Rezaei.
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|a London :
|b Academic Press,
|c [2022]
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|a 1 online resource
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|a Translational Immunology ;
|v 1
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|a Print version record.
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|a Intro -- Translational Autoimmunity, Vol. 1: Etiology of Autoimmune Diseases -- Copyright -- Dedication -- Contents -- Contributors -- Preface -- Series editor biography -- Acknowledgment -- Abbreviations -- Chapter 1 Introduction on translational autoimmunity: From bench to bedside -- 1 Introduction -- 2 Autoimmune disorders -- 3 Pathogenesis and mechanisms of autoimmune diseases -- 4 Predisposing factors -- 5 Role of genetics -- 6 Obstacles in treatment -- 7 Diagnostic tools -- 8 Role of innate immunity -- 9 Conclusion -- References -- Chapter 2 Autophagy in autoimmunity -- 1 Introduction -- 2 An overview of autophagy -- 3 Autophagy in immunity -- 3.1 Autophagy in innate immunity -- 3.1.1 Elimination of pathogens by autophagy -- 3.1.2 Autophagy in inflammation regulation -- 3.2 Autophagy in adaptive immunity -- 3.2.1 Antigen presentation -- 3.2.2 Lymphocyte differentiation and survival -- Autophagy in T cells -- Autophagy in B cells -- 4 Autophagy in autoimmune diseases -- 4.1 Autophagy in SLE -- 4.2 Autophagy in RA -- 4.3 Autophagy in MS -- 4.4 Autophagy in AIH -- 5 Conclusion -- Acknowledgments -- Conflict of interest -- References -- Chapter 3 Immunometabolism and autoimmunity -- 1 Introduction -- 2 Immunometabolism in homeostasis -- 2.1 T cell metabolism -- 2.2 B cell metabolism -- 2.3 Macrophage metabolism -- 3 Immunometabolism in autoimmunity -- 3.1 SLE -- 3.2 RA -- 3.3 MS -- 3.4 Autoinflammatory diseases -- 4 Conclusion -- References -- Chapter 4 T cell recognition of neoepitopes in autoimmunity -- 1 Introduction -- 2 The mystery of lost tolerance in autoimmunity -- 3 Determinant spreading in autoimmune disease -- 4 Neoepitopes as a challenge to immune tolerance -- 4.1 Autoimmune susceptible HLA enhance presentation of neoepitope peptides -- 4.2 Increased TCR recognition of neoepitope peptides.
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|a 5 T cell recognition of citrullinated neoepitopes in rheumatoid arthritis -- 6 T cell recognition of deamidated neoepitopes in CD -- 7 T cell recognition of neo-antigens in T1D -- 7.1 Cellular stress and upregulation of modifying enzymes -- 7.2 Cellular stress and alteration of the encoded proteome of target cells -- 8 Prospects for diagnostic detection of neoepitope specific T cell responses -- 9 Conclusion -- References -- Chapter 5 Role of Th1 and Th2 in autoimmunity -- 1 Introduction -- 1.1 Lymphocytes development, maturation, and "central tolerance" -- 1.2 Lymphocytes migration in the body and "peripheral tolerance" -- 1.3 Lymphocytes roles and plasticity: The Th1/Th2 hypothesis -- 2 Th1 and Th2 generation -- 2.1 Th1 polarization -- 2.2 Th2 polarization -- 3 Th1 and Th2 response in health -- 3.1 Th1 response -- 3.2 Th2 response -- 4 Breakdown of tolerance: Autoimmunity and allergy -- 4.1 Th1 in disease -- 4.2 Th2 in disease -- 5 Conclusion -- References -- Chapter 6 Role of Th17 cell in tissue inflammation and organ-specific autoimmunity -- 1 Introduction -- 2 Differentiation of IL-17-producing Th17 cells -- 3 Amplification of Th17 cells -- 4 Stabilization of Th17 cells -- 5 Transcriptional regulation of Th17 cells -- 6 Regulators of Th17 cells -- 6.1 IL-27 and Th17 cells -- 6.2 IL-10 and Th17 cells -- 6.3 IL-2 and Th17 cells -- 6.4 IL-25 and Th17 cells -- 6.5 STATS as a negative regulator of Th17 cells -- 7 Small molecules inhibitor of Th17 cells -- 8 Role of Th17 cells in the pathogenesis of autoimmune diseases -- 8.1 Alopecia areata -- 8.2 Systemic lupus erythematosus -- 8.3 Type 1 diabetes mellitus -- 8.4 S�jgren syndrome -- 8.5 Periodontitis and oral lichen planus -- 8.6 Autoimmune thyroid disorders -- 8.7 Noninfectious uveitis -- 8.8 Myasthenia gravis -- 8.9 Ankylosing spondylitis -- 8.10 Juvenile idiopathic arthritis.
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|a 8.11 Systemic sclerosis -- 8.12 Psoriasis -- 8.13 Inflammatory bowel disease -- 8.14 Multiple sclerosis -- 8.15 Rheumatoid arthritis -- 9 Conclusion -- Acknowledgments -- References -- Chapter 7 Peptide editing and its modulation in CD4 + T cell tolerance to self -- 1 Introduction -- 2 Cellular adaptive immunity in health and disease -- 2.1 Basics of CD4 + T cell responses -- 2.2 HLA genes and proteins, and their link to autoimmunity -- 2.3 Basics of HLAII antigen presentation and the relevance of peptide editing -- 2.4 Peptide editing in different antigen presenting cells -- 2.5 Recognition of pMHCII by the TCR: The key step towards T cell activation -- 3 Tolerance mechanisms: training lymphocytes for a proper self and non-self recognition -- 3.1 Central tolerance -- 3.1.1 Positive selection -- 3.1.2 Negative selection or clonal deletion -- 3.1.3 Treg selection in the thymus -- 3.2 Peripheral tolerance -- 3.2.1 Ignorance -- 3.2.2 Anergy -- 3.2.3 Clonal deletion, peripheral Treg conversion and suppressor function -- 3.3 Peptide editing in the context of the affinity and avidity models for T cell activation and tolerance acquisition -- 4 Peptide editing in the targets of organ-specific autoimmune diseases -- 5 Conclusion -- References -- Chapter 8 Innate lymphoid cells in autoimmune diseases -- 1 Introduction -- 2 ILCs as crucial components of the mammalian immune system -- 2.1 Group 1 ILCs or ILC1s as potential innate immune lymphoid cells -- 2.2 Group 2 ILCs or ILC2s in immunity and inflammation -- 2.3 Group 3 ILCs or ILC3s in immunity and inflammation -- 3 ILCs in ADs -- 3.1 Group 1 ILCs or ILC1s in ADs -- 3.2 Group 2 ILCs or ILC2s in ADs -- 3.3 Group 3 ILCs or ILC3s in ADs -- 4 Conclusion -- References -- Chapter 9 Autoimmune diseases and the role of Toll-like receptor-7 and -9 signaling cascades -- 1 Introduction -- 2 Toll-like receptors.
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| 650 |
|
0 |
|a Autoimmunity.
|
| 650 |
|
0 |
|a Immunology.
|
| 650 |
|
2 |
|a Autoimmunity
|0 (DNLM)D015551
|
| 650 |
|
2 |
|a Allergy and Immunology
|0 (DNLM)D000486
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| 650 |
|
6 |
|a Auto-immunit�e.
|0 (CaQQLa)201-0060759
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| 650 |
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6 |
|a Immunologie.
|0 (CaQQLa)201-0066630
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| 650 |
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7 |
|a Autoimmunity
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|0 (OCoLC)fst00822674
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|a Immunology
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| 700 |
1 |
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|a Rezaei, Nima,
|e editor.
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|i Print version:
|z 0128225645
|z 9780128225646
|w (OCoLC)1252962574
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|i Print version:
|t TRANSLATIONAL AUTOIMMUNITY.
|d [S.l.] : ELSEVIER ACADEMIC PRESS, 2021
|z 0128225645
|w (OCoLC)1252962574
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4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128225646
|z Texto completo
|
