Advances in virus research Volume 111 /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mettenleiter, Thomas C. (Editor ), Kielian, Margaret C., 1952- (Editor ), Roossinck, Marilyn J. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2021.
Colección:Advances in virus research ; v. 111
Temas:
Virology.
Virology > Research.
Virologie.
Virologie > Recherche.
Virology
Virology > Research
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Advances in Virus Research
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Parainfluenza virus entry at the onset of infection
  • 1. Introduction to parainfluenza virus infection and entry
  • 2. HN�s structure and receptor binding
  • 3. F: Primed for action in its pre-fusion state
  • 4. HN interaction with F and HN�s role in the activation of F
  • 5. The transient intermediate state of F
  • 6. Final stages of fusion and entry
  • 7. Fitness requirements of the HN/F fusion complex in human lung
  • 8. Inhibitors of entry
  • 8.1. Antivirals targeting HN�s role in receptor binding
  • 8.2. Hijacking HN to trigger F prematurely
  • 8.3. Antibodies that target F�s conformation or HN-F interaction
  • 8.4. Blocking fusion at F�s transitional intermediate state
  • 9. Future directions
  • Acknowledgments
  • References
  • Chapter Two: Molecular archeology of human viruses
  • 1. Three decades of aDNA research and more than a century of virology set expectations for archeovirology
  • 1.1. Lessons from aDNA and aRNA
  • 1.2. Lessons from virology
  • 2. Promises and pitfalls of archeovirology
  • 2.1. Survival, detectability and authentication of ancient viral sequences
  • 2.1.1. Specimen/sample types
  • 2.1.2. Selection/detection method
  • 2.1.3. Authentication/phylogenetic dating criterion
  • 2.2. Key questions of archeovirology
  • 2.2.1. Origins and timescales
  • 2.2.2. Diversity and its temporal dynamics
  • 3. Outlook
  • References
  • Chapter Three: Advancing phage therapy through the lens of virus host-breadth and emergence potential
  • 1. Phage biology, and the history and promise of phage therapy
  • 1.1. Combating antibiotic-resistant bacteria could capitalize on lytic phage biology
  • 1.2. Historical development of phage therapy
  • 1.2.1. Discovery of phages
  • 1.2.2. Politics of phage therapy
  • 1.2.3. Phage therapy vs antibiotics.
  • 1.3. Phage therapy offers many advantages over traditional antibiotics
  • 1.4. Limitations to phage therapy
  • 2. Phage host-range and development of generalized treatment
  • 2.1. Host-range (specialism vs generalism) in lytic phages
  • 2.2. Considerations for using few vs many phages in administered treatment
  • 2.3. Observations and measures of host-range breadth in phages
  • 2.4. Case example: Exploring host-range of lytic phages targeting P. aeruginosa
  • 2.4.1. Study design to test killing ability of naturally-occurring phages across challenge hosts
  • 2.4.2. Naturally-occurring phages differ in relative specialism vs generalism in host-use
  • 2.4.3. Phage productivity on susceptible bacteria is additionally informative for gauging host-breadth
  • 2.4.4. Using ``greedy algorithms�� to estimate useful combinations of phages for generalized treatment
  • 2.4.5. Testing efficacy of a cocktail using in-vitro experiments on known and novel host strains
  • 3. Phages can evolve in response to their environments, potentially altering host breadth
  • 3.1. Evolution and ecology matter in phage-therapy development
  • 3.1.1. Mutation rates affect phage evolution
  • 3.1.2. Beyond mutations: Other sources of genetic material
  • 3.1.3. Phages can evolve during treatment
  • 3.1.4. Lessons from the emergence of zoonotic diseases
  • 3.1.5. Lessons from experimental evolution
  • 4. Conclusion
  • Acknowledgments
  • Appendix
  • References
  • Chapter Four: Alphavirus RNA replication in vertebrate cells
  • 1. Introduction
  • 2. Viral components of the RNA replication machinery
  • 2.1. Precursors of ns-proteins
  • 2.2. nsP1
  • 2.3. nsP2
  • 2.4. nsP3
  • 2.5. nsP4
  • 3. Host components of RNA replication machinery
  • 4. Architecture, functioning, biogenesis and properties of replication complexes.
  • 5. Functional interactions between components of alphavirus RNA replication machinery
  • 6. Replicase inhibitors
  • 7. Conclusions and perspectives
  • Acknowledgments
  • References.

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