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|2 23
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|a Current research on naturally transmitted Plasmodium knowlesi /
|c edited by Chris Drakeley.
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|a London :
|b Academic Press,
|c 2021.
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
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|a online resource
|b cr
|2 rdacarrier
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|a Advances in parasitology ;
|v v. 113
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|a Print version record.
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|a Intro -- Current research on naturally transmitted Plasmodium knowlesi -- Copyright -- Contents -- Contributors -- Plasmodium knowlesi, an infectious disease challenge for our times -- References -- Chapter One: Knowlesi malaria: Human risk factors, clinical spectrum, and pathophysiology -- 1. Introduction -- 2. Transmission in humans -- 3. Life cycle in humans -- 4. Human risk factors for symptomatic infection -- 5. Prepatent and incubation periods -- 6. Clinical spectrum in malariotherapy and experimental human infection -- 7. Clinical spectrum in natural infection -- 7.1. Asymptomatic infections -- 7.2. Symptoms in adults -- 7.3. Clinical signs in adults -- 7.4. Laboratory investigations in adults -- 7.4.1. Haematology -- 7.4.2. Parasitaemia -- 7.4.3. Liver function -- 7.4.4. Renal function -- 7.5. Severe knowlesi malaria -- 7.6. Clinical and parasitological risk factors for severe disease -- 7.7. Deaths from knowlesi malaria -- 7.8. Knowlesi malaria in children -- 7.9. Knowlesi malaria in pregnancy -- 7.10. Congenital malaria -- 8. Genetic risk factors -- 8.1. Parasite genetics -- 8.2. Host genetics -- 9. Pathophysiology -- 9.1. Microvascular accumulation of parasites -- 9.2. Endothelial activation, dysfunction and glycocalyx breakdown -- 9.3. Systemic inflammatory response -- 9.4. Intravascular haemolysis -- 9.5. Thrombocytopenia -- 9.6. Anaemia -- 10. Conclusion -- Acknowledgements -- References -- Chapter Two: Clinical management of Plasmodium knowlesi malaria -- 1. Introduction -- 2. Diagnosis of Plasmodium knowlesi -- 3. In vitro susceptibility of P. knowlesi to antimalarial agents -- 4. Drug resistance mutations -- 5. Treatment of uncomplicated knowlesi malaria -- 5.1. Artemisinin combination treatment (ACT) -- 5.2. Chloroquine -- 5.3. Other agents -- 5.4. Primaquine -- 6. Clinical management of severe knowlesi malaria.
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|a 6.1. Intravenous artesunate -- 6.2. Paracetamol as a renoprotective agent -- 6.3. Other adjunctive and supportive treatment -- 7. Treatment of knowlesi malaria in children -- 8. Treatment of knowlesi malaria in pregnancy -- 9. Conclusions -- Acknowledgements -- References -- Chapter Three: Plasmodium knowlesi detection methods for human infections-Diagnosis and surveillance -- 1. Introduction -- 2. Point-of-care diagnosis -- 2.1. Microscopy -- 2.1.1. P. knowlesi morphology in human infections -- 2.1.2. P. knowlesi parasite count measurements -- 2.1.3. P. knowlesi life stages in human infections -- 2.1.4. Diagnostic performance of routine malaria microscopy for P. knowlesi infections -- 2.1.5. Automated visualisation of blood films for detecting P. knowlesi infections -- 2.2. Rapid diagnostic tests -- 2.2.1. Pan-pLDH based RDTs -- 2.2.2. P. falciparum and P. vivax-pLDH antibody cross-reactivity with P. knowlesi -- 2.2.3. Pan-aldolase based RDTs -- 2.2.4. RDT use in returned travellers from endemic countries -- 2.2.5. RDT detection for Plasmodium species in monkey hosts -- 2.2.6. Summary and recommendations for RDT use -- 3. Molecular detection -- 3.1. PCR assays -- 3.1.1. Background -- 3.1.2. Alternative target genes for P. knowlesi identification -- 3.1.3. Comparative performance of PCR assays -- 3.1.4. Detection of submicroscopic or asymptomatic infections -- 3.1.5. Molecular detection of P. knowlesi gametocytes -- 3.2. Loop-mediated isothermal amplification (LAMP) -- 3.2.1. LAMP platforms -- 3.2.2. P. knowlesi specific LAMP primers -- 3.2.3. Challenges for LAMP as a diagnostic tool -- 3.2.4. The future of LAMP for P. knowlesi diagnosis -- 4. Serology -- 4.1. Importance of serology for malaria surveillance -- 4.2. Development of serologic assays for P. knowlesi detection -- 4.3. Potential use case scenarios for P. knowlesi serologic tools.
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|a 5. Conclusion -- Acknowledgements -- References -- Chapter Four: The vectors of Plasmodium knowlesi and other simian malarias Southeast Asia: challenges in malaria elimination -- 1. Introduction -- 2. Simian malaria parasites in natural vector mosquitoes -- 2.1. Phylogenetic position of Plasmodium knowlesi amongst malaria parasites -- 2.2. Detected simian malaria parasites in vector mosquitoes -- 3. Vectors of Plasmodium knowlesi-Leucosphyrus Group of Anopheles -- 3.1. Phylogenetic studies of vectors in the Leucosphyrus Group of Anopheles -- 3.2. Natural vectors of Plasmodium knowlesi in the Leucosphyrous Group of Anopheles -- 4. Bionomics of natural vectors of Plasmodium kowlesi in the Leucosphyrus Group of Anopheles -- 4.1. Larval biology -- 4.2. Biting habits of vectors -- 4.3. Host preferences -- 4.4. Vectorial capacity and life expectancy of knowlesi simian malaria vectors -- 5. Suspected vectors of knowlesi malaria in other Anopheles Groups -- 6. Experimental transmissions of Plasmodium knowlesi and other simian malaria parasites in mosquitoes -- 6.1. Experimental studies on Plasmodium knowlesi in mosquitoes -- 6.2. Implication of experimental studies using vectors on the transmission of P. knowlesi and other simian malarias in nature -- 6.2.1. Mosquito:Plasmodium compatibility -- 6.2.2. Gametocytaemia and timing of simian malaria transmission to the mosquitoes -- 6.2.3. Can some experimental vectors transmit the parasites in the wild? -- 7. Control of vectors of P. knowlesi and other simian malarias -- 7.1. Tools for control of simian malaria -- 7.2. Vector control for simian malaria in Southeast Asia -- 7.2.1. Insecticidal nets and indoor residual spraying -- 7.2.2. Larvicides -- 7.2.3. Insecticide-treated hammocks -- 7.2.4. Topical repellents -- 7.2.5. Spatial repellents -- 7.2.6. Endectocides -- 8. Challenges.
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|a 9. Conclusions and the way forward -- Acknowledgement -- References -- Chapter Five: Molecular epidemiology and population genomics of Plasmodium knowlesi -- 1. Molecular detection in discovery of Plasmodium knowlesi as a significant zoonosis -- 2. Molecular surveys of the distribution of P. knowlesi infections in humans -- 2.1. P. knowlesi in humans -- 2.2. P. knowlesi in primate reservoir hosts -- 2.3. P. knowlesi in mosquito vectors -- 3. Early utility of a few genetic loci for analysis of P. knowlesi polymorphism -- 3.1. Initial informative studies involving sequencing of individual genes -- 3.2. Mitochondrial genome sequencing and haplotype relationships -- 4. Multi-locus microsatellite analyses of P. knowlesi uncovers population structure -- 5. Whole-genome sequence analysis of P. knowlesi subpopulation divergence -- 6. Loci under positive natural selection in the P. knowlesi genome -- 7. Assays for efficient surveillance of different P. knowlesi subpopulations -- 8. Adaptation and the future of P. knowlesi emerging from local zoonoses -- References -- Chapter Six: Epidemiology of the zoonotic malaria Plasmodium knowlesi in changing landscapes -- 1. Introduction -- 2. Ecological change and mechanisms of disease emergence and transmission -- 2.1. Biodiversity impacts on vector-borne and zoonotic diseases -- 2.2. Habitat fragmentation and zoonotic and vector-borne diseases -- 2.3. Physical changes to the environment and disease transmission -- 2.4. Socio-economic changes and development and disease risks -- 3. Distribution and burden of Plasmodium knowlesi -- 3.1. Spatial distribution of reported P. knowlesi incidence -- 3.2. Community-level spatial distribution of exposure and infection -- 3.3. Reporting bias and surveillance for P. knowlesi -- 3.4. Emergence of other zoonotic simian malarias in Southeast Asia.
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| 505 |
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|a 4. Landscape impacts on P. knowlesi disease dynamics -- 4.1. Environmental change in Southeast Asia -- 4.2. Impacts of environmental change on distribution of P. knowlesi -- 4.3. Human populations, movement and occupational risks -- 4.4. Simian host ecology and infection rates -- 4.5. Mosquito ecology, infection and bionomics -- 5. Transmission dynamics and potential for human to human transmission -- 6. Designing surveillance and control measures for changing environments -- 6.1. Opportunities to improve surveillance for P. knowlesi -- 6.2. Management of wildlife populations -- 6.3. Land management strategies -- 7. Conclusions and future research priorities -- References.
|
| 650 |
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0 |
|a Parasitology.
|
| 650 |
|
0 |
|a Plasmodium.
|
| 650 |
|
2 |
|a Parasitology
|0 (DNLM)D010274
|
| 650 |
|
2 |
|a Plasmodium
|0 (DNLM)D010961
|
| 650 |
|
6 |
|a Parasitologie.
|0 (CaQQLa)201-0024233
|
| 650 |
|
6 |
|a Plasmodium.
|0 (CaQQLa)201-0080527
|
| 650 |
|
7 |
|a Parasitology
|2 fast
|0 (OCoLC)fst01053186
|
| 650 |
|
7 |
|a Plasmodium
|2 fast
|0 (OCoLC)fst01066395
|
| 700 |
1 |
|
|a Drakeley, Chris.
|
| 776 |
0 |
8 |
|i Print version:
|z 9780323907279
|z 032390727X
|w (OCoLC)1253472730
|
| 830 |
|
0 |
|a Advances in parasitology ;
|v v. 113.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/0065308X/113
|z Texto completo
|
