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Scientific principles of adipose stem cells /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press,
[2022]
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Scientific Principles of Adipose Stem Cells
- Copyright
- Dedication
- Contents
- Contributors
- Preface
- Part 1: Introduction and front matter
- Chapter 1: Plastic surgery, fat, and fat plasticity: How adipose tissue changed the landscape of stem cell therapeutics
- Plastic surgery and fat plasticity
- The Adipose Stem Cell Center in Pittsburgh and the International Federation of Adipose Therapeutics and Science
- References
- Part 2: Basic biology of adipose stem cells
- Chapter 2: Developmental origins of adipocytes: What we learn from human pluripotent stem cells
- Introduction: Three types of adipocytes in mammals
- Developmental origins of white adipocytes
- White adipocytes from mouse embryonic stem cells derive from neural crest
- White adipocyte developmental origins in quail and mouse embryos
- Lineage tracing studies reveal a complex situation for the developmental origins of adipocytes
- Subcutaneous and visceral adipocytes have different developmental origins
- White, beige, and brown adipocytes originate from different developmental pathways: Evidence of mosaic origins in individua ...
- Human models to investigate the developmental origins of adipocytes
- Capacity of human pluripotent stem cells to generate adipocytes
- Human pluripotent stem cell commitment toward the white and brown-like adipogenic lineage is regulated by the retinoic acid ...
- Adipocytes derived from human induced pluripotent stem cells display a brown-like adipocyte phenotype and originate from me ...
- hiPSC-3D adipospheres: The next steps toward gaining greater insight into the development of human brown-like adipocytes
- Importance of matching the embryonic origin between transplanted cells and the host environment for tissue regeneration: A ...
- References.
- Chapter 3: Establishing the adipose stem cell identity: Characterization assays and functional properties
- Introduction
- Physical characterization
- Morphological characterization
- Assessment of proliferation
- Colony-forming unit-fibroblast assay
- Phenotypic characterization
- Positive selection markers
- Negative selection markers
- Multipotent differentiation
- Adipogenesis
- Mechanism(s) of differentiation
- Differentiation methodology
- Confirmation of adipogenesis
- Adipose stem cell adipocyte secretome
- Osteogenesis
- Mechanism(s) of differentiation
- Differentiation method
- Confirmation of osteogenesis
- Adipose stem cell osteoblast secretome
- Chondrogenesis
- Mechanism(s) of differentiation
- Differentiation method
- Confirmation of chondrogenesis
- Adipose stem cell chondrocyte secretome
- Characterization of in vitro immunomodulatory abilities
- Adipose stem cells and the innate immune system
- Macrophages
- Dendritic cells
- Natural killer cells
- Adipose stem cells and the adaptive immune system
- T cells
- CD4+ T cells
- CD8+ T cells
- B cells
- Summary
- Conclusion and future directions
- References
- Chapter 4: Insights into the adipose stem cell niche in health and disease
- Introduction
- Defining adipocyte-derived stem cells and progenitors
- Generation of adipocytes from adipocyte precursors
- Adipocyte precursors reside in the stromal vasculature fraction
- Immunophenotyping of ASCs and APs
- Adipocyte precursors in the native niche
- Adipocyte precursors located in the adipose extracellular matrix
- Perivascular cells as a source of adipocyte precursors
- Fibroblastic cells as a source of adipocyte precursors
- Cell interactions within the adipose precursor niche
- Adipocyte precursor interactions with endothelial cells
- Adipocyte precursor interactions with immune cells.
- Adipocyte precursor interactions with other cells in the niche
- Fibroblast growth factor signaling and renewal of adipocyte precursors
- Bone morphogenetic proteins and commitment of adipogenic precursors
- BMP2 acts as a paracrine factor within human white adipose tissue
- BMP4 promotes a white or brown phenotype in a context-dependent manner
- BMP7 promotes commitment of brown/beige adipocyte precursors
- Adipose-derived stem cells express core regulators of self-renewal and pluripotency
- OCT4, NANOG, and SOX2 expression in adipose-derived stem cells
- OCT4 and NANOG are required to maintain stemness in adipose-derived stem cells
- Changes in adipose-derived stem cells during obesity and metabolic disease
- Changes in adipocyte progenitors during aging may contribute to metabolic dysfunction
- Conclusions and future perspectives
- Acknowledgments and funding support
- References
- Chapter 5: Mechanisms of adipose-derived stem cell aging and the impact on therapeutic potential
- Introduction
- General aging background
- Adipose-derived stem cell aging mechanisms
- How adipose-derived stem cell aging impacts current clinical application of adipose-derived stem cells
- Current molecular attempts at rejuvenating stem cells for clinical applications
- Summary
- References
- Chapter 6: Human pluripotent nontumorigenic multilineage differentiating stress enduring (Muse) cells isolated from adipo ...
- Discovery of Muse and adipose-derived multilineage-differentiating stress-enduring cells
- Components of adipose tissue
- Adipose stem cells
- Adipose-derived Muse cells vs adipose stem cells
- Differences between isolation methodology
- Differences in gene expression
- Pluripotency vs multipotency
- Properties of adipose-derived Muse cells
- Pluripotency of adipose-derived Muse cells.
- Nontumorigenic properties of adipose-derived Muse cells
- Immunomodulatory properties of adipose-derived Muse cells
- Evolutionary bases of adipose-derived Muse cells
- Clinical perspective of adipose-derived Muse cells
- Skepticism behind adipose-derived Muse cells
- Conclusions
- Acknowledgments
- References
- Chapter 7: Adipose stem cell homing and routes of delivery
- Introduction
- Homing steps
- Strategies to enhance homing of ASCs
- Priming
- Use of inflammatory cytokines
- Hypoxia
- Genetic modification
- Routes of MSC delivery
- Intravenous delivery
- Intraarterial delivery
- Intraparenchymal delivery
- Current challenges in adipose stem cell homing therapy
- References
- Chapter 8: Bioreactors and microphysiological systems for adipose-based pharmacologic screening
- Introduction
- Components of adipose-based microphysiological systems and bioreactors
- Adipocytes
- Brown versus white adipose tissue
- Subcutaneous versus visceral adipose tissue
- Primary cells
- Embryonic stem cells and induced pluripotent stem cells
- Immortalized cells
- Extracellular matrix
- Considerations
- Materials for microphysiological systems/bioreactors
- Static versus perfusion
- Other considerations
- Chemical gradients
- Coculture components of microphysiological systems/bioreactors
- Inflammation
- Vascularization
- Current adipose-based microphysiological systems/bioreactors
- Adipose-tissue-on-a-chip systems
- Human-on-a-chip systems
- Microcarriers
- Organoids
- Assessments of microphysiological systems and bioreactors
- Adipokines
- Lipogenesis
- Lipolysis
- Insulin response
- Nondestructive imaging techniques
- Oxygen tension
- Future directions
- References
- Part 3: Adipose cell therapy and regenerative medicine.
- Chapter 9: Adipose stem cells and donor demographics: Impact of anatomic location, donor sex, race, BMI, and health
- Introduction
- Sources of adipose stem cells
- Clinically relevant harvest sites
- Effects of harvesting technique
- Patient demographics
- Male versus female
- Race and ethnicity
- Effects of patient health
- Body mass index
- Immune status
- Smoking
- Clinical translation
- Studies of adipose tissue retention based on donor demographics
- Clinical studies
- References
- Chapter 10: Immunomodulatory properties of adipose stem cells in vivo: Preclinical and clinical applications
- Introduction
- Immunomodulatory effects
- Mechanisms
- T cells
- B cells
- Macrophages, natural killer cells, and dendritic cells
- Purine metabolism
- Migration and homing: In vivo tracking
- Transplantation
- Solid organ transplantation
- Kidney transplantation
- Heart transplantation
- Vascularized composite allotransplantation
- Graft versus host disease
- Autoimmune disorders
- Inflammatory bowel disease
- Rheumatoid arthritis and osteoarthritis
- Type 1 diabetes mellitus
- Multiple sclerosis
- Other conditions
- Ischemic conditions
- Neurodegenerative disorders
- Chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
- Vasculitis
- Conclusions and future directions
- References
- Chapter 11: Clinical experience with adipose tissue enriched with adipose stem cells
- A brief history
- The value of fat
- Adipose composition
- Adipose-derived stem cells
- Tools and techniques
- Principles of adipose harvest
- Clinical perspective
- Donor site preparation
- Tumescence
- Pretunneling
- Liposuction modalities
- Suction-assisted lipectomy
- Water-jet assisted liposuction
- Ultrasound-assisted liposuction
- Laser-assisted liposuction
- Cannula selection.