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Principles of translational science in medicine : from bench to bedside /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2021.
|
| Edición: | Third edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Part I: Introduction. 1. Introduction and definitions ; 2. Problems, challenges, and initiatives in translation
- Part II. Target identification and validation ; 3. "Omics" translation: a challenge for laboratory medicine ; 4. The power of genomics, metabolomics, and other omics for target identification and validation ; 5. Potency analysis of cellular therapies: the role of molecular assays ; 6. Translational pharmacogenetics: pharmacogenetically driven clinical decision making ; 7. Tissue biobanks ; 8. Animal models: value and translational potency ; 9. Biomarkers in the context of health authorities and consortia ; 10. Human studies as a source of target information ; 11. Target profiling in terms of translatability and early translation planning
- Part III. Biomarkers as key elements of successful translation. 12. Biomarkers ; 13. Genetics, molecular biomarkers, and artificial intelligence to improve diagnostic and prognostic efficacy ; 14. Cardiovascular translational biomarkers: translational aspects of hypertension, atherosclerosis, and heart failure in drug development in the digital era ; 15. Biomarkers in oncology ; 16. Translational medicine in psychiatry: challenges and imaging biomarkers
- Part IV: Early clinical trial design. 17. Methodological studies ; 18. The pharmaceutical research and development productivity crisis: can exploratory clinical studies be of any help? ; 19. Adaptive trial design ; 20. Combining regulatory and exploratory trials ; 21. Accelerating proof of concept by smart early clinical trials
- Part V: Toxicology in translation. 22. Pharmaceutical toxicology ; 23. Translational safety medicine
- Part VI: Special topics in translation. 24. Cancer vaccines: translational strategies ; 25. Translational aspects of biologicals: monoclonal antibodies and antibody-drug conjugates as examples ; 26. Orphan drugs: why is translation so successful?
- Part VII: Biostatistics and modelling. 27. Translational science biostatistics ; 28. Computational biology and model-based approaches in translational medicine
- Part VIII. Legal aspects and special interest groups. 29. Intellectual property and innovation in translational medicine ; 30. Translational research in the fastest-growing population: older adults
- Part IX. Integration and application of translational guidance. 31. Translational medicine: the changing role of big pharma ; 32. Translational science in medicine: putting the pieces together-biomarkers, early human trials, networking, and translatability assessment ; 33. Learning by experience.