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|z 9780128204931
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|b P75 2021
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|a 610.72
|2 23
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| 245 |
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|a Principles of translational science in medicine :
|b from bench to bedside /
|c edited by Martin Wehling.
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| 250 |
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|a Third edition.
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| 264 |
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1 |
|a Amsterdam :
|b Academic Press,
|c 2021.
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| 300 |
|
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|a 1 online resource (xv, 477 pages) :
|b illustrations (black and white, and color)
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| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 500 |
|
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|a Previous edition: 2015.
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| 504 |
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|a Includes bibliographical references and index.
|
| 588 |
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|a Online resource; title from title screen (Ebook Central, viewed February 25, 2022).
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| 505 |
0 |
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|a Part I: Introduction. 1. Introduction and definitions ; 2. Problems, challenges, and initiatives in translation -- Part II. Target identification and validation ; 3. "Omics" translation: a challenge for laboratory medicine ; 4. The power of genomics, metabolomics, and other omics for target identification and validation ; 5. Potency analysis of cellular therapies: the role of molecular assays ; 6. Translational pharmacogenetics: pharmacogenetically driven clinical decision making ; 7. Tissue biobanks ; 8. Animal models: value and translational potency ; 9. Biomarkers in the context of health authorities and consortia ; 10. Human studies as a source of target information ; 11. Target profiling in terms of translatability and early translation planning -- Part III. Biomarkers as key elements of successful translation. 12. Biomarkers ; 13. Genetics, molecular biomarkers, and artificial intelligence to improve diagnostic and prognostic efficacy ; 14. Cardiovascular translational biomarkers: translational aspects of hypertension, atherosclerosis, and heart failure in drug development in the digital era ; 15. Biomarkers in oncology ; 16. Translational medicine in psychiatry: challenges and imaging biomarkers -- Part IV: Early clinical trial design. 17. Methodological studies ; 18. The pharmaceutical research and development productivity crisis: can exploratory clinical studies be of any help? ; 19. Adaptive trial design ; 20. Combining regulatory and exploratory trials ; 21. Accelerating proof of concept by smart early clinical trials -- Part V: Toxicology in translation. 22. Pharmaceutical toxicology ; 23. Translational safety medicine -- Part VI: Special topics in translation. 24. Cancer vaccines: translational strategies ; 25. Translational aspects of biologicals: monoclonal antibodies and antibody-drug conjugates as examples ; 26. Orphan drugs: why is translation so successful? -- Part VII: Biostatistics and modelling. 27. Translational science biostatistics ; 28. Computational biology and model-based approaches in translational medicine -- Part VIII. Legal aspects and special interest groups. 29. Intellectual property and innovation in translational medicine ; 30. Translational research in the fastest-growing population: older adults -- Part IX. Integration and application of translational guidance. 31. Translational medicine: the changing role of big pharma ; 32. Translational science in medicine: putting the pieces together-biomarkers, early human trials, networking, and translatability assessment ; 33. Learning by experience.
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| 650 |
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|a Medical innovations.
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| 650 |
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|a Medicine
|x Research.
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| 650 |
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2 |
|a Translational Research, Biomedical
|0 (DNLM)D057170
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| 650 |
|
6 |
|a M�edecine
|x Innovations.
|0 (CaQQLa)201-0046524
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| 650 |
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6 |
|a M�edecine
|x Recherche.
|0 (CaQQLa)201-0004698
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| 650 |
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7 |
|a Medical innovations
|2 fast
|0 (OCoLC)fst01014181
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| 650 |
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7 |
|a Medicine
|x Research
|2 fast
|0 (OCoLC)fst01015059
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| 700 |
1 |
|
|a Wehling, Martin,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Principles of translational science in medicine.
|b Third edition.
|d Amsterdam : Academic Press, 2021
|z 9780128204931
|w (OCoLC)1255869690
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128204931
|z Texto completo
|
