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Sex and gender differences in alzheimer's disease : the women's brain project /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
2021.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Sex and Gender Differences in Alzheimer's Disease: The Women's Brain Project
- Copyright
- Dedication
- Contents
- Contributors
- Acknowledgments
- Introduction
- Editors' biography
- Foreword
- Section 1: Sex differences in fundamental neurobiological processes that are relevant to Alzheimer's disease
- Chapter 1 Sex differences in Alzheimer's disease animal models
- Overview of Alzheimer's disease
- AD animal models
- Mutant APP mouse models
- Mouse models with multiple FAD mutations
- Mouse models of tau pathology
- Other AD mutant models
- Evidence for sex differences in AD animal models
- The triple transgenic AD mouse model: 3xTg-AD
- Age-dependent behavioral sex differences
- Sex differences in glucose homeostasis and immune function
- Olfaction and hormonal-related factors
- Lifespan
- APP and PSEN1 transgenic mouse models: TgCRND8, APPswe/PSEN1dE9, APPPS1, and PS2APP/Trem2KO
- ApoE transgenic mouse models: ApoE4/3xTg, 5xFAD/ApoE3, and 5xFAD/ApoE4
- Tau mouse models: P301S, rTg4510, JNPL3
- Nontransgenic animals
- Limitations
- Conclusion
- Chapter highlights
- References
- Chapter 2 Sex and sex hormone differences in hippocampal neurogenesis and their relevance to Alzheimer's disease
- Introduction
- Adult neurogenesis in the dentate gyrus
- The function of adult neurogenesis in the hippocampus
- Neurogenesis and aging
- Sex differences in neurogenesis
- Sex differences in neurogenesis in the context of cognitive training
- Alzheimer's disease
- Sex differences in Alzheimer's disease
- Animal models for Alzheimer's disease and sex differences
- Neurogenesis in Alzheimer's disease
- Neurogenesis in models of Alzheimer's disease
- Estrogens and aging
- Estrogens and neurogenesis
- Estrogens and neurogenesis in the context of aging
- Estrogens, aging, and cognition.
- Structural MRI
- Structural MRI sex differences in healthy subjects
- Structural MRI sex differences in dementia
- Conclusion
- Functional MRI
- fMRI sex differences in healthy subjects
- fMRI sex differences in dementia
- Conclusion
- Perfusion SPECT
- Perfusion SPECT sex differences in healthy subjects
- Perfusion SPECT sex differences in dementia
- Conclusion
- Dat Spect
- DAT SPECT sex differences in healthy subjects
- DAT SPECT sex differences in dementia
- Fdg-Pet
- FDG-PET sex differences in healthy subjects
- FDG-PET sex differences in dementia
- Amyloid PET
- Amyloid PET sex differences in healthy subjects
- Amyloid PET sex differences in dementia
- Conclusion
- Emerging PET modalities
- Tau PET sex differences in healthy subjects and dementia
- Neurotransmission PET sex differences in healthy subjects and dementia
- Neuroinflammation PET sex differences in healthy subjects and dementia
- Conclusion
- Chapter highlights
- References
- Chapter 6 Sex and gender differe nces in neuropsychological symptoms for clinical diagnosis of Alzheimer's disease
- Introduction
- Memory
- Introduction
- Sex/gender differences in verbal memory in healthy adults
- Sex/gender differences in verbal memory in mild cognitive impairment
- Sex/gender differences in verbal memory in AD
- Sex/gender differences and rates of verbal memory decline
- Summary
- Language
- Introduction
- Laterality, handedness, and connectivity of the language system
- Semantic dysfunction in neural disorders other than AD
- Critical semantic disruption in AD
- Executive function
- Introduction
- Sex/gender differences in executive function
- Sex/gender differences in cognitive reserve mechanisms
- Conclusion
- Chapter highlights
- Support
- References
- Chapter 7 Sex differences in psychiatric disorders and their implication for dementia.
- Psychiatric disorders matter as modifiable risk factors for dementia over the entire life span
- Major depression: A relevant modifiable risk factor for dementia with sex- and gender-related implications
- Social signal transduction theory of depression: A hypothesis to explain the female's increased vulnerability during child ...
- Late life versus earlier life depression and risk of developing dementia
- Depression or dementia? A key diagnostic challenge in the elderly
- Pharmacotherapy in the elderly: A major challenge with the risk of detrimental polypharmacy
- Antidepressants in dementia
- Polypharmacy
- Behavioral and psychological symptoms of dementia
- Treatment of BPSD: A key challenge in dementia care
- Benzodiazepines in the elderly
- Conclusion
- Chapter highlights
- References
- Chapter 8 Sleep disorders and dementia
- Why do we spend a third of life sleeping? An introduction to sleep and its main characteristics
- Sleep disorders and physiological sleep changes during aging
- Sex- and gender-related differences in sleep and sleep disorders
- Sleep disorders in Alzheimer's disease
- Sleep architecture in Alzheimer's disease
- Treating sleep disorders in Alzheimer's disease
- Sleep disorders and Alzheimer's disease: The caregiver's burden
- Key points
- Insomnia: An independent risk factor for cognitive impairment
- Treating sleep disorders in the elderly
- Key points
- Obstructive sleep apnea syndrome: A risk factor for cognitive impairment and Alzheimer's disease
- Obstructive sleep apnea syndrome and the different clinical pictures in male and female patients
- Obstructive sleep apnea syndrome in relation to cognitive impairment and Alzheimer's disease
- Biomarkers in OSAS and Alzheimer's disease
- Key points.
- REM sleep behavior disorder: A relevant parasomnia and an early clinical biomarker for neurodegenerative diseases
- REM sleep behavior disorder and sex- and gender-related differences
- REM sleep behavior disorder and the risk of clinical manifestation of a neurodegenerative disease
- Sundown syndrome in Alzheimer's disease is associated with RBD
- Key points
- Conclusion
- Chapter highlights
- References
- Chapter 9 Hormones and dementia
- Sex differences are hormone differences
- Hormones and cognition
- Estrogen
- Progesterone
- Testosterone and DHEA
- Menopause and cognition
- Natural menopause
- Surgical menopause
- Observational studies of hormone therapy use
- Interventional HT use
- Hormone therapy and cognition
- Hormone therapy in younger women
- The timing hypothesis
- Side-effect profile
- Hormones and cognition in men
- Gaps in knowledge
- The impact of hormones on known key risk factors for cognitive decline
- Vascular risk and disease (BMI, HT, lipids (APOE4))
- Diabetes and impaired glucose tolerance
- Metabolic syndrome and inflammation
- Depression
- Sleep
- Midlife to late-life longitudinal prospective studies including hormone, cognitive, and neuropathological biomarkers
- Timing and therapeutic windows
- Information on all types of HT preparation
- Conclusion
- Chapter highlights
- References
- Chapter 10 Sex and gender differences in genetic and lifestyle risk and protective factors for dementia
- Introduction
- APOE allele
- Hormones, menopause, and andropause
- Hormone replacement therapy
- Reproductive history and timing of menopause
- Andropause
- Cardiometabolic risk factors
- Smoking and alcohol consumption
- Physical activity and exercise
- Nutrition
- Sleep disturbances
- Neural reserve and resilience
- Sex and gender dichotomies in cognitive aging research.