Advances in clinical chemistry. Volume 103 /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Makowski, Gregory S. (Gregory Stephen) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, is an imprint of Elsevier, 2021.
Temas:
Clinical chemistry.
Chemistry, Clinical
Chimie clinique.
Clinical chemistry
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Advances in Clinical Chemistry
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Chapter One: Autoantibodies to tumor-associated antigens in lung cancer diagnosis
  • 1. Introduction
  • 2. TAAs and TAAbs
  • 3. Common technologies to identify TAAs in LC
  • 3.1. SEREX
  • 3.2. SERPA
  • 3.3. Protein microarray
  • 4. Major issues for identifying TAAs in cancer diagnosis
  • 5. Development of TAAbs as biomarkers in LC diagnosis
  • 5.1. Diagnostic performance of single TAAbs for LC
  • 5.2. Diagnostic value of TAAbs panels for LC diagnosis
  • 5.3. Early detection of TAAbs in LC at pre-clinical stage
  • 6. Combination of TAAbs with other indicators in LC detection
  • 7. The prognostic value of TAAbs in LC
  • 8. Conclusion and future perspectives
  • Acknowledgment
  • References
  • Chapter Two: Extracellular vesicles in cardiovascular disease
  • 1. Introduction
  • 2. Discovery and nomenclature of EVs
  • 3. EVs as a potential source for biomarker discovery in cardiovascular disease
  • 3.1. Extracellular vesicle counts
  • 3.2. Extracellular vesicle contents
  • 3.2.1. Extracellular vesicle proteins
  • 3.2.2. Extracellular vesicle lipids
  • 3.2.3. Extracellular vesicle nucleic acids
  • 4. Potential of EVs as therapeutics in cardiovascular disease
  • 4.1. Preclinical testing of EVs as therapeutics in CVD
  • 4.1.1. Atherosclerosis
  • 4.1.2. Myocardial infarction
  • 4.1.3. Stroke
  • 4.2. Clinical translation
  • 5. Potential of EVs as drug delivery systems in cardiovascular disease
  • 5.1. Atherosclerosis
  • 5.2. Myocardial infarction
  • 5.3. Stroke
  • 6. Current methods for the isolation of naturally secreted EVs
  • 6.1. Differential ultracentrifugation
  • 6.2. Density gradient ultracentrifugation
  • 6.3. Immunoaffinity (monoclonal antibody based) method
  • 6.4. Ultrafiltration
  • 6.5. Size exclusion chromatography
  • 6.6. Polymer precipitation.

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