Diseases of the nervous system /

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The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non--invasive imaging, and research fueled by public and private investment in biomedical research has...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Sontheimer, Harald (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, United Kingdom ; San Diego, CA : Academic Press, an imprint of Elsevier, [2021]
Edición:Second edition.
Temas:
Nervous system > Diseases.
Nervous System Diseases
Syst�eme nerveux > Maladies.
Nervous system > Diseases
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Section I: Static nervous system diseases
  • Chapter 1.
  • Cerebrovascular infarct: Stroke
  • 1 Case Story
  • 2 History
  • 3 Clinical presentation/diagnosis/epidemiology
  • 4 Disease mechanism/cause/basic science
  • 5 Treatment/standard of care/clinical management
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and opportunities
  • Acknowledgment
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Papers
  • Basic Papers
  • Chapter 2.
  • Central Nervous System Trauma
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation/Diagnosis/Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Treatment/Standard of Care/Clinical Management
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgements
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Papers
  • Basic Papers
  • Chapter 3.
  • Seizure Disorders and Epilepsy
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation/Diagnosis/Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Treatment/Standard of Care/Clinical management
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgments
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Basic
  • Clinical
  • Section II: Progressive Neurodegenerative Diseases
  • Chapter 4.
  • Aging, Dementia, and Alzheimer Disease
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation/Diagnosis/Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Treatment/Standard of Care/Clinical Management
  • 6 Experimental approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgements
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Paper
  • Basic Science Paper
  • Chapter 5.
  • Parkinson Disease *
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation, Diagnosis, and Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Treatment/Standard of Care/Clinical Management
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgement
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club assignments
  • Clinical Paper
  • Basic Paper
  • Chapter 6.
  • Diseases of motor neurons and neuromuscular junctions
  • 1 Case story
  • 2 History
  • 3 Clinical presentation/diagnosis/epidemiology
  • 4 Disease mechanism/cause/basic science
  • 5 Treatment/standard of care/clinical management
  • 6 Experimental approaches/clinical trials
  • 7 Challenges and opportunities
  • Acknowledgements
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Papers
  • Basic Papers
  • Chapter 7.
  • Huntington Disease *
  • 1 Case Story
  • 2 History
  • 3 Clinical presentation/Diagnosis/Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Treatment/Standard of Care/ Clinical Management
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgements
  • References
  • Genera; Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Papers
  • Basic Papers
  • Section III: Secondary progressive neurodegenerative diseases
  • Chapter 8.
  • Multiple Sclerosis
  • 1 Case story
  • 2 History
  • 3 Clinical Presentation/diagnosis/epidemiology
  • 4 Disease mechanism/cause/basic science
  • 5 Treatment/standard of care/clinical management
  • 6 Experimental approaches/clinical trials
  • 7 Challenges and opportunities
  • Acknowledgements
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical papers
  • Basic Papers
  • Chapter 9.
  • Brain Tumors
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation/Diagnosis/Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Treatment/Standard of Care/Clinical Management
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgements
  • References
  • General Readings Used as Source
  • Suggested papers or Journal Club Assignments
  • Clinical Paper
  • Basic
  • Chapter 10.
  • Infectious Diseases of the Nervous System
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation/Diagnosis/Epidemiology/Disease Mechanism
  • 4 Beyond the infection: Bona Fide Brain Disorders involving Pathogens
  • 5 Experimental approaches/Clinical Trials
  • 6 Challenges and Opportunities
  • Acknowledgements
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Paper
  • Basic
  • Section IV: Developmental Neurological Conditions
  • Chapter 11.
  • Neurodevelopmental Disorders
  • 1 Case Study
  • 2 History
  • 3 Developmental of Synapses in the Human Cortex and Diseases Thereof
  • 4 Down Syndrome
  • 5 Fragile X Syndrome
  • 6 Rett syndrome
  • 7 Autism Spectrum Disorder (ASD)
  • 8 Common Disease Mechanism
  • 9 Challenges and Opportunities
  • Acknowledgment
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Papers
  • Basic Papers
  • Section V: Neuropsychiatric Illnesses
  • Chapter 12.
  • Mood Disorders and Depression
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation/Diagnosis/Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Treatment/Standard of Care/Clinical Management
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgement
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Papers
  • Basic Papers
  • Chapter 13.
  • Schizophrenia
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation/Diagnosis/Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Treatment/Standard of Care/Clinical Management
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgements
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Papers
  • Basic Papers
  • Chapter 14.
  • Pain
  • 1 Case Story
  • 2 History
  • 3 Clinical Presentation/Diagnosis/Epidemiology
  • 4 Disease Mechanism/Cause/Basic Science
  • 5 Common Forms of Pain and Currently Approved Treatments
  • 6 Experimental Approaches/Clinical Trials
  • 7 Challenges and Opportunities
  • Acknowledgements
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical
  • Basic
  • Chapter 15.
  • Drug Addiction
  • 1 Case Story
  • 2 History and Drug Use and Addiction
  • 3 Biology of Substance Use and Addiction
  • 4 Common Substance Use Disorders, Underlying Biology, Epidemiology, and Treatment
  • 5 Challenges and Opportunities
  • Acknowledgments
  • References
  • General Readings Used
  • Readings for Journal Club
  • Clinical
  • Basic
  • Section VI: Common Concepts in Neurological and Neuropsychiatric illnesses
  • Chapter 16.
  • Shared Mechanisms of Disease
  • 1 Introduction
  • 2 Neuronal Death
  • 3 Glutamate Toxicity
  • 4 Protein aggregates and Prion-Like Spread of Disease
  • 5 Mitochondrial Dysfunction
  • 6 Heritability of Disease With Elusive Genetic Causes
  • 7 Epigenetics
  • 8 Noncell Autonomous Mechanisms
  • 9 Inflammation
  • 10 Vascular Abnormalities
  • 11 Brain-Derives Neurotrophic Factor
  • 12 Challenges and Opportunities
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Clinical Papers
  • Basic Papers
  • Section VII: Bench-To-Bedside Translation
  • Chapter 17.
  • Drug Discovery and Personalized Medicine
  • 1 Introduction
  • 2 How Did We Get to This Point? A Brief History
  • 3 Drug Discovery: How Are Candidate Drugs Identified?
  • 4 What Are Clinical Trials and Why Do Them?
  • 5 The Placebo Effect
  • 6 Why Do Clinical Trials Fall?
  • 7 Personalized Medicine
  • 8 Challenges and Opportunities
  • References
  • General Readings Used as Source
  • Suggested Papers or Journal Club Assignments
  • Section VIII: Neuroscience Jargon
  • Chapter 18.
  • "Neuro"-Dictionary

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