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Diseases of the nervous system /
The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non--invasive imaging, and research fueled by public and private investment in biomedical research has...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom ; San Diego, CA :
Academic Press, an imprint of Elsevier,
[2021]
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| Edición: | Second edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Sontheimer, Harald, |e author. | |
| 245 | 1 | 0 | |a Diseases of the nervous system / |c Harald Sontheimer, Harrison Distinguished Professor and Chair, Department of Neuroscience, University of Virginia, School of Medicine, Charlottesvilla, VA, United States. |
| 250 | |a Second edition. | ||
| 264 | 1 | |a London, United Kingdom ; |a San Diego, CA : |b Academic Press, an imprint of Elsevier, |c [2021] | |
| 264 | 4 | |c �2021 | |
| 300 | |a 1 online resource (xviii, 481 pages) : |b illustrations (chiefly color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 505 | 0 | |a Section I: Static nervous system diseases -- Chapter 1. -- Cerebrovascular infarct: Stroke -- 1 Case Story -- 2 History -- 3 Clinical presentation/diagnosis/epidemiology -- 4 Disease mechanism/cause/basic science -- 5 Treatment/standard of care/clinical management -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and opportunities -- Acknowledgment -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Papers -- Basic Papers -- Chapter 2. -- Central Nervous System Trauma -- 1 Case Story -- 2 History -- 3 Clinical Presentation/Diagnosis/Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Treatment/Standard of Care/Clinical Management -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgements -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Papers -- Basic Papers -- Chapter 3. -- Seizure Disorders and Epilepsy -- 1 Case Story -- 2 History -- 3 Clinical Presentation/Diagnosis/Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Treatment/Standard of Care/Clinical management -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgments -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Basic -- Clinical -- | |
| 505 | 8 | |a Section II: Progressive Neurodegenerative Diseases -- Chapter 4. -- Aging, Dementia, and Alzheimer Disease -- 1 Case Story -- 2 History -- 3 Clinical Presentation/Diagnosis/Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Treatment/Standard of Care/Clinical Management -- 6 Experimental approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgements -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Paper -- Basic Science Paper -- Chapter 5. -- Parkinson Disease * -- 1 Case Story -- 2 History -- 3 Clinical Presentation, Diagnosis, and Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Treatment/Standard of Care/Clinical Management -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgement -- References -- General Readings Used as Source -- Suggested Papers or Journal Club assignments -- Clinical Paper -- Basic Paper -- Chapter 6. -- Diseases of motor neurons and neuromuscular junctions -- 1 Case story -- 2 History -- 3 Clinical presentation/diagnosis/epidemiology -- 4 Disease mechanism/cause/basic science -- 5 Treatment/standard of care/clinical management -- 6 Experimental approaches/clinical trials -- 7 Challenges and opportunities -- Acknowledgements -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Papers -- Basic Papers -- Chapter 7. -- Huntington Disease * -- 1 Case Story -- 2 History -- 3 Clinical presentation/Diagnosis/Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Treatment/Standard of Care/ Clinical Management -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgements -- References -- Genera; Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Papers -- Basic Papers -- | |
| 505 | 8 | |a Section III: Secondary progressive neurodegenerative diseases -- Chapter 8. -- Multiple Sclerosis -- 1 Case story -- 2 History -- 3 Clinical Presentation/diagnosis/epidemiology -- 4 Disease mechanism/cause/basic science -- 5 Treatment/standard of care/clinical management -- 6 Experimental approaches/clinical trials -- 7 Challenges and opportunities -- Acknowledgements -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical papers -- Basic Papers -- Chapter 9. -- Brain Tumors -- 1 Case Story -- 2 History -- 3 Clinical Presentation/Diagnosis/Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Treatment/Standard of Care/Clinical Management -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgements -- References -- General Readings Used as Source -- Suggested papers or Journal Club Assignments -- Clinical Paper -- Basic -- Chapter 10. -- Infectious Diseases of the Nervous System -- 1 Case Story -- 2 History -- 3 Clinical Presentation/Diagnosis/Epidemiology/Disease Mechanism -- 4 Beyond the infection: Bona Fide Brain Disorders involving Pathogens -- 5 Experimental approaches/Clinical Trials -- 6 Challenges and Opportunities -- Acknowledgements -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Paper -- Basic -- Section IV: Developmental Neurological Conditions -- Chapter 11. -- Neurodevelopmental Disorders -- 1 Case Study -- 2 History -- 3 Developmental of Synapses in the Human Cortex and Diseases Thereof -- 4 Down Syndrome -- 5 Fragile X Syndrome -- 6 Rett syndrome -- 7 Autism Spectrum Disorder (ASD) -- 8 Common Disease Mechanism -- 9 Challenges and Opportunities -- Acknowledgment -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Papers -- Basic Papers -- | |
| 505 | 8 | |a Section V: Neuropsychiatric Illnesses -- Chapter 12. -- Mood Disorders and Depression -- 1 Case Story -- 2 History -- 3 Clinical Presentation/Diagnosis/Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Treatment/Standard of Care/Clinical Management -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgement -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Papers -- Basic Papers -- Chapter 13. -- Schizophrenia -- 1 Case Story -- 2 History -- 3 Clinical Presentation/Diagnosis/Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Treatment/Standard of Care/Clinical Management -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgements -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Papers -- Basic Papers -- Chapter 14. -- Pain -- 1 Case Story -- 2 History -- 3 Clinical Presentation/Diagnosis/Epidemiology -- 4 Disease Mechanism/Cause/Basic Science -- 5 Common Forms of Pain and Currently Approved Treatments -- 6 Experimental Approaches/Clinical Trials -- 7 Challenges and Opportunities -- Acknowledgements -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical -- Basic -- Chapter 15. -- Drug Addiction -- 1 Case Story -- 2 History and Drug Use and Addiction -- 3 Biology of Substance Use and Addiction -- 4 Common Substance Use Disorders, Underlying Biology, Epidemiology, and Treatment -- 5 Challenges and Opportunities -- Acknowledgments -- References -- General Readings Used -- Readings for Journal Club -- Clinical -- Basic -- | |
| 505 | 8 | |a Section VI: Common Concepts in Neurological and Neuropsychiatric illnesses -- Chapter 16. -- Shared Mechanisms of Disease -- 1 Introduction -- 2 Neuronal Death -- 3 Glutamate Toxicity -- 4 Protein aggregates and Prion-Like Spread of Disease -- 5 Mitochondrial Dysfunction -- 6 Heritability of Disease With Elusive Genetic Causes -- 7 Epigenetics -- 8 Noncell Autonomous Mechanisms -- 9 Inflammation -- 10 Vascular Abnormalities -- 11 Brain-Derives Neurotrophic Factor -- 12 Challenges and Opportunities -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Clinical Papers -- Basic Papers -- Section VII: Bench-To-Bedside Translation -- Chapter 17. -- Drug Discovery and Personalized Medicine -- 1 Introduction -- 2 How Did We Get to This Point? A Brief History -- 3 Drug Discovery: How Are Candidate Drugs Identified? -- 4 What Are Clinical Trials and Why Do Them? -- 5 The Placebo Effect -- 6 Why Do Clinical Trials Fall? -- 7 Personalized Medicine -- 8 Challenges and Opportunities -- References -- General Readings Used as Source -- Suggested Papers or Journal Club Assignments -- Section VIII: Neuroscience Jargon -- Chapter 18. -- "Neuro"-Dictionary | |
| 504 | |a Includes bibliographical references and index. | ||
| 500 | |a Revised edition of: Diseases of the nervous system / Harald Sontheimer. [2015]. | ||
| 520 | |a The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non--invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand--alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Nervous system |x Diseases. | |
| 650 | 2 | |a Nervous System Diseases |0 (DNLM)D009422 | |
| 650 | 6 | |a Syst�eme nerveux |x Maladies. |0 (CaQQLa)201-0007359 | |
| 650 | 7 | |a Nervous system |x Diseases |2 fast |0 (OCoLC)fst01036098 | |
| 776 | 0 | 8 | |i Print version: |a Sontheimer, Harald. |t Diseases of the nervous system. |b Second edition. |d Amsterdam : Academic Press, 2021 |z 9780128212288 |w (OCoLC)1255844797 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128212288 |z Texto completo |