Human hypothalamus : neuropsychiatric disorders /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Swaab, D. F. (Dick Frans)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Elsevier, 2021.
Colección:Handbook of clinical neurology ; v. 182.
Temas:
Hypothalamus.
Neurobehavioral disorders.
Human beings.
Humans
Hypothalamus
Hypothalamus > abnormalities
Neurocognitive Disorders
Troubles neurocognitifs.
�Etres humains.
Homo sapiens (species)
Neurobehavioral disorders
Internet Resources.
Index not Present.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • The Human Hypothalamus: Neuropsychiatric Disorders
  • Copyright
  • Foreword
  • Preface
  • The HCN volumes on the Human Hypothalamus
  • The hypothalamus: Arbitrary borders
  • References
  • Contributors
  • Contents
  • Contents of related volumes
  • Chapter 1: Introduction: The human hypothalamus and neuropsychiatric disorders
  • Section 21Continued from the previous volume.: Trauma and Iatrogenic Disorders
  • Section 22: Neurobehavioral Disorders
  • Section 23: Epilepsy
  • Section 24: Neurodegenerative Disorders
  • Section 25: Olfactory System
  • Section 26: Autonomic and Sleep Disorders
  • Section 27: Addiction and Pain
  • Section 28: Critical Care and Brain Death
  • References
  • Section 21: Trauma and iatrogenic disorders
  • Chapter 2: Chronic traumatic encephalopathy and the nucleus basalis of Meynert
  • Introduction
  • Pathologic Features of CTE
  • CTE Tau Pathological Staging
  • Nucleus Basalis of Meynert in CTE
  • Cholinergic Basal Forebrain Subfields
  • Septal (Ch1) and diagonal band (Ch2-Ch3) cholinergic neurons
  • Nucleus basalis (Ch4) cholinergic neurons
  • Cholinergic nbM Dysfunction in CTE
  • Tau NFT Pathology Within the nbM in CTE
  • p62 profiles within the nbM in CTE
  • Transactive response DNA-binding protein of 43 (TDP-43 or TARDBP) in the nbM in CTE
  • Amyloid Pathology in the nbM in CTE
  • nbM Cortical Cholinergic Disconnection in CTE
  • White Matter Disruption of nbM Axons in CTE
  • Transcript Expression in CTE
  • Cholinergic Transcript Dysregulation in Tau-Containing nbM Neurons in CTE
  • Chrnb2 dysregulation in nbM neurons in CTE
  • Dopaminergic transcript dysregulation in tau positive nbM neurons in CTE
  • Calcium transcript dysregulation in tau positive nbM neurons in CTE
  • Endocytic transcript dysregulation in tau positive nbM neurons in CTE.
  • Cyclic adenosine monophosphate transcript dysregulation in tau positive nbM neurons in CTE
  • Lissencephalic-1 transcript dysregulation in tau positive nbM neurons in CTE
  • Chloride channel transcript dysregulation in tau positive nbM neurons in CTE
  • Clinical Consequences of nbM Pathobiology in CTE
  • Conclusions
  • Acknowledgments
  • References
  • Section 22: Neurobehavioral disorders
  • Chapter 3: Hypothalamic stress systems in mood disorders
  • Stress System Dysfunction in Mood Disorders
  • CRH and AVP
  • Oxytocin
  • Neuropeptides S and Y
  • Orexins
  • Translation of Neuropeptide Pharmacology Into Novel Medicines
  • Corticotropin-releasing hormone (CRH)-Receptor type 1 (CRHR1) antagonists for treatment of major depr
  • Vasopressin (AVP) 1B (V1b)-receptor antagonists for treatment of acute major depression
  • Dual orexin receptor antagonists (DORAs) for treatment of insomnia and depression
  • Conclusion
  • References
  • Chapter 4: Light therapy for mood disorders
  • Introduction
  • The beginning: Seasonal affective disorder
  • Etiology of seasonal affective disorder
  • Pathophysiology of (Peripartum) Mood Disorders
  • The role of the hypothalamus-pituitary-adrenal axis
  • The peripartum hypothalamus-pituitary-adrenal axis
  • Fetal programming of the hypothalamus-pituitary-adrenal axis
  • The role of the circadian rhythm
  • The peripartum circadian rhythm
  • Working Mechanisms of Light Therapy
  • Clinical Studies of Light Therapy
  • Light therapy for depression
  • Light therapy for depression during pregnancy
  • Light therapy for postpartum depression
  • Light therapy for bipolar disorder
  • Conclusions
  • References
  • Chapter 5: Neurobiology of peripartum mental illness
  • Introduction to the Parental Brain
  • Peripartum Mental Illness Occurs in One in Seven Women
  • Neurobiology of Peripartum Mental Illness
  • Peripartum anxiety disorders.
  • Peripartum depression
  • Substance use disorder in the peripartum period
  • Other peripartum mental illnesses
  • Other Factors Influencing Peripartum Mental Illness
  • Concluding Remarks and Future Directions
  • Acknowledgments
  • References
  • Chapter 6: The hypothalamo-pituitary-adrenal axis and the autonomic nervous system in burnout
  • Introduction
  • The burnout concept
  • Clinical burnout
  • Hypothalamo-Pituitary-Adrenal Axis in Burnout
  • Basal HPA axis activity
  • Cortisol awakening response
  • Diurnal HPA axis activity
  • Hair cortisol
  • Response to challenges
  • Longitudinal studies
  • Anabolic hormones
  • Autonomic System in Burnout
  • Resting autonomic activity
  • Response to challenges
  • Longitudinal studies
  • Methodologic Aspects
  • Summary
  • References
  • Chapter 7: Posterior hypothalamus as a target in the treatment of aggression: From lesioning to deep brain stimulation
  • Introduction
  • Clinical Correlates of Aggression
  • Laboratory Experiences: Roots of Surgical Approach for Aggressive Disorders
  • At the Dawn of Surgery for Aggressive Disorders: The Lesional Era
  • A Step Into Brain Stimulation: The DBS Era
  • From the Target to the Circuit
  • Debate around the target: ``Posterior hypothalamus�� or ``A region posterior to the hypothala
  • Circuit modulation
  • Conclusions
  • References
  • Chapter 8: The implications of hypothalamic abnormalities for schizophrenia
  • Introduction11Abbreviations used in the chapter are listed at the end of the chapter before References section.
  • Hypothalamic Gross Anatomic Pathology in Schizophrenia
  • Hypothalamic Cell Pathology in Schizophrenia
  • Concentrations of Classical Neurotransmitters and Their Metabolites
  • Changes in Hypothalamic Neurosecretory Neurons
  • Alterations of Hypothalamic-Releasing and Inhibiting Factors Which Regulate Hormonal Axes.
  • Alteration of Peptide Hormones Regulating Food Intake, Appetite, and Satiety
  • Alteration of Hypothalamic Opioid Peptides: POMC, Endorphins, and Enkephalins
  • Alterations in the Expression of Susceptibility Genes for Schizophrenia
  • Role of the Hypothalamus in Sleep Disturbances in Schizophrenia
  • Disease-Related Neuroinflammatory and Neuroimmune Disturbances and the Impact of the Hypothalamus
  • Conclusions
  • References
  • Chapter 9: The promiscuity of the oxytocin-vasopressin systems and their involvement in autism spectrum disorder
  • Introduction: Oxytocin and Vasopressin Synthesis, Gene Structure, and Function
  • Evolutionary History of Oxytocin and Vasopressin Ligands and Receptors
  • Oxytocin and Vasopressin Ligand and Receptor Distribution in the Human and Mouse Brain
  • Oxytocin and Vasopressin Regulate Social Behaviors
  • Gene blockade and activation studies (knockout, pharmacological, chemogenetic, optogenetic)
  • Oxytocin/vasopressin concentration and administration studies
  • Epigenetic studies
  • Single-nucleotide polymorphism (SNP) studies
  • Oxytocinergic and Vasopressinergic Systems Are Impaired in ASD and Related Animal Models
  • Nonhuman animal models
  • Human patients
  • Treatments for ASD Targeting the Oxytocinergic and Vasopressinergic Systems
  • Treatments targeting the oxytocin system in adults
  • In nonhuman animal models
  • In human patients
  • Treatments targeting the oxytocin system during development
  • In nonhuman animal models
  • In human patients
  • Treatments targeting the vasopressin system
  • In nonhuman animal models
  • In human subjects
  • Oxytocin and behavioral therapies
  • Conclusion
  • References
  • Section 23: Epilepsy
  • Chapter 10: Gelastic seizures and the hypothalamic hamartoma syndrome: Epileptogenesis beyond the lesion?
  • Introduction.
  • MRI-Based Classification of HH With Regard to Clinical Phenotypes
  • Seizure Semiology in Epilepsy With HH
  • Gelastic seizures
  • Dacrystic seizures
  • Other seizure types
  • Epilepsy with HH as a Model of Secondary Epileptogenesis
  • Secondary epileptogenesis: Basis and principles
  • Secondary epileptogenesis and hypothalamic kindling: Experimental data
  • Intrinsic epileptogenicity of the HH: Arguments from invasive recordings
  • Human data arguing for secondary epileptogenesis in HH
  • Secondary Epileptogenesis and the Concept of Epileptogenic Networks
  • Illustrative cases from Marseille series
  • Conclusions
  • References
  • Chapter 11: The interactions between reproductive hormones and epilepsy
  • Introduction
  • The Effects of Hormones on Epilepsy
  • Neuroactive properties of reproductive steroid hormones
  • Estradiol
  • Progesterone and its metabolites
  • Androgens
  • Effects of hormones on epilepsy-Clinical implications
  • Puberty
  • Catamenial epilepsy
  • Changes in seizure frequency during pregnancy and effect of prior history of catamenial epilepsy
  • Menopause
  • Hormonal treatment
  • The Effects of Epilepsy on Reproductive Endocrine Function
  • The role of epilepsy in women
  • The role of epilepsy in men
  • Antiepileptic Drug-Related Mechanisms
  • Reproductive endocrine effects of antiepileptic drugs in men
  • Phenobarbital, phenytoin, and carbamazepine
  • Valproate
  • Oxcarbazepine
  • Lamotrigine
  • Other new antiepileptic drugs
  • Reproductive endocrine effects of AEDs in male subjects with epilepsy during pubertal development
  • Reproductive endocrine effects of antiepileptic drugs in women
  • Phenobarbital, phenytoin, and carbamazepine
  • Valproate
  • Oxcarbazepine
  • Lamotrigine
  • Other new antiepileptic drugs
  • Reversibility of the reproductive endocrine effects of antiepileptic drugs after discontinuation of the medication.

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