Human hypothalamus : neuroendocrine disorders /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Swaab, D. F. (Dick Frans), Buijs, Ruud M., Lucassen, Paul J., Salehi, Ahmad, Kreier, Felix
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [Place of publication not identified] : Elsevier, 2021.
Colección:Handbook of clinical neurology ; v. 181.
Temas:
Hypothalamus.
Humans
Hypothalamus
Hypothalamus > abnormalities
Internet Resources.
Index not Present.
Acceso en línea:Texto completo
Texto completo
Tabla de Contenidos:
  • Intro
  • The Human Hypothalamus: Neuroendocrine Disorders
  • Copyright
  • Handbook of Clinical Neurology 3rd Series
  • Foreword
  • Preface
  • The HCN volumes on the Human Hypothalamus
  • The hypothalamus: Arbitrary borders
  • References
  • Contributors
  • Contents
  • Contents of related volumes
  • Chapter 1: Introduction: The human hypothalamus and neuroendocrine disorders
  • Section 15#: Structural Disorders of the Hypothalamo-pituitary Region
  • Section 16: Tumors of the Hypothalamus
  • Section 17: Neuroimmunological Disorders
  • Section 18: Drinking Disorders
  • Section 19: Eating Disorders
  • Section 20: Reproduction and Sexual Behavior
  • References
  • Section 15: Structural disorders of the hypothalamo-pituitary region
  • Chapter 2: Pituitary stalk interruption syndrome
  • Introduction
  • Epidemiology
  • Magnetic Resonance Imaging findings
  • Clinical Manifestations
  • Hormonal Profile and Evolution of Hormone Deficiencies
  • Treatment
  • Pathogenesis of Pituitary Stalk Interruption Syndrome
  • Genetics of Pituitary Stalk Interruption Syndrome
  • Genes involved in pituitary organogenesis
  • Genes involved in neural development
  • Holoprosencephaly (HPE)-related genes
  • Cilia-related genes
  • PSIS associated with microdeletions or duplications
  • Digenic and polygenic inheritance and the application of next generation sequencing
  • Environmental Factors and PSIS
  • Conclusions and Perspectives
  • References
  • Chapter 3: Empty sella syndrome: Multiple endocrine disorders
  • Introduction
  • Classification
  • Epidemiology
  • Pathogenesis of Empty Sella
  • Presenting Clinical Manifestations
  • Endocrine symptoms
  • Neurological and ophthalmological symptoms
  • Diagnosis
  • Endocrinological assessment
  • Ophthalmological assessment
  • Radiological assessment
  • Differential Diagnosis
  • Treatment Strategies
  • Hypopituitarism.
  • Intracranial hypertension
  • Follow-Up
  • Prognosis
  • Conclusion
  • Acknowledgments
  • Declaration in interest
  • Funding
  • References
  • Chapter 4: Pituitary dysfunction after aneurysmal subarachnoidal hemorrhage
  • Introduction
  • Epidemiology
  • Treatment and Management of aSAH
  • Neuroendocrine Dysfunction in aSAH Patients
  • Neuroendocrine Dysfunction in the Acute Phase after aSAH
  • ACTH in the acute phase after aSAH
  • FSH/LH in the acute phase after aSAH
  • GH in the acute phase after aSAH
  • TSH in the acute phase after aSAH
  • Overall neuroendocrine dysfunction in the acute phase after aSAH
  • Neuroendocrine Dysfunction in the Chronic Phase after aSAH
  • ACTH in the chronic phase after aSAH
  • FSH/LH in the chronic phase after aSAH
  • GH in the chronic phase after aSAH
  • TSH in the chronic phase after aSAH
  • Overall neuroendocrine dysfunction in the chronic phase after aSAH
  • Neuroendocrine Dysfunction in aSAH Patients: Changes from the Acute to the Chronic Phase
  • Conclusions
  • References
  • Chapter 5: Septo-optic dysplasia
  • Introduction
  • Etiology and Pathogenesis
  • Development of the Forebrain and Pituitary Gland
  • Neuropathological Studies
  • Epidemiology
  • Clinical Presentation
  • Visual disturbances
  • Endocrinology disturbances
  • Neurologic aspects
  • Diagnostic Stage
  • Ophthalmologic assessment
  • Neuroradiology investigation
  • Endocrinology workup
  • Additional investigations
  • Clinical and Surgical Management
  • Prognosis and Outcome
  • Conclusion
  • Acknowledgments
  • Disclosure
  • References
  • Section 16: Tumors of the hypothalamus
  • Chapter 6: Hypothalamic hormone-producing tumors
  • Introduction
  • Tumor Classification, Clinical, and Morphological Features
  • Therapeutic Approaches
  • References
  • Chapter 7: Craniopharyngiomas primarily affecting the hypothalamus
  • Introduction1.
  • Craniopharyngioma: A pituitary, suprasellar or hypothalamic tumor?
  • Craniopharyngiomas primarily affecting the hypothalamus: Definition, anatomical relationships, and embryological origin
  • Hypothalamus involvement by craniopharyngiomas: Historical insights
  • Hypothalamus-referenced topographical classification of craniopharyngiomas
  • Hypothalamic dysfunction caused by CPs: Infundibulo-tuberal syndrome versus hypothalamic syndrome
  • Infundibulo-tuberal syndrome
  • Hypothalamic syndrome
  • Fr�ohlich's syndrome: Pathogenesis of sexual immaturity
  • Hypothalamic obesity in craniopharyngioma patients
  • Pathogenesis of hypothalamic obesity in Hy-CP patients: The role of astrogliosis
  • Diurnal somnolence in CP patients
  • Emotional, cognitive, and psychiatric disturbances: Clinical landmarks of Hy-CPs
  • MRI assessment of CP-hypothalamus relationships: The usefulness of the mamillary body angle
  • Surgical risk: The formidable problem of CP-hypothalamic adhesions
  • Surgical strategies for CPs primarily affecting the hypothalamus
  • Complications and sequelae derived from surgically caused hypothalamic injury
  • Radiosurgery, proton beam therapy, and chemotherapy for the treatment of CPs involving the hypothalamus
  • Genetic profile and targeted therapy for papillary CPs involving the hypothalamus
  • Conclusions
  • Acknowledgments
  • Compliance with ethical standards
  • Sources of funding
  • Disclosure of potential conflict of interest
  • Abbreviations
  • References
  • Section 17: Neuroimmunological disorders
  • Chapter 8: The stress-axis in multiple sclerosis: Clinical, cellular, and molecular aspects
  • Introduction
  • The Stress-Axis in MS
  • Determinants of Stress-Axis Responsiveness
  • Neurodegeneration vs inflammation
  • Sex and subtype-specific differences
  • Differences in glucocorticoid receptor genotype.
  • Pathological, Cellular, and Molecular Effects of Stress-Axis Responsiveness
  • Clinical Correlates of HPA Axis Activity in MS
  • Outlook
  • References
  • Chapter 9: Neuroendocrine manifestations of Langerhans cell histiocytosis
  • Introduction
  • Epidemiology
  • Diagnostic Criteria
  • Neuroendocrine Manifestations of LCH
  • Anterior pituitary hormones deficiency
  • Posterior pituitary hormones deficiency
  • Hypothalamic involvement
  • Others sites of involvement
  • Management of LCH
  • Chemotherapy
  • Management of neuroendocrine manifestations in LCH
  • Follow-up of LCH patients
  • Conclusions
  • References
  • Chapter 10: Neuroendocrine manifestations of Erdheim-Chester disease
  • Introduction
  • Manifestations of Hypothalamus, Pituitary Stalk, and/or Pituitary Gland Lesions
  • Manifestations of Posterior Pituitary Hormone Deficiencies (Arginine Vasopressin and/or Oxytocin Deficiencies)
  • Manifestations of Anterior Pituitary Hormone Deficiencies
  • ACTH Deficiency (Hypothalamic-Pituitary-Adrenal Axis)
  • TSH Deficiency (Hypothalamic-Pituitary-Thyroid Axis)
  • GH Deficiency
  • Gonadotropin Deficiency (Hypothalamic-Pituitary-Gonadal Axis)
  • Hyperprolactinemia
  • PRL Deficiency
  • Conclusions
  • References
  • Chapter 11: Hypothalamitis and pituitary atrophy
  • Introduction
  • Pathogenesis
  • Clinical Presentation
  • Diagnosis
  • Neuroradiological features
  • Differential Diagnosis
  • Treatment
  • Prognosis
  • Conclusion
  • References
  • Chapter 12: Narcolepsy Type I as an autoimmune disorder
  • Narcolepsy Type 1
  • Genetic Associations in Narcolepsy Type 1
  • Environmental Factors Linked to Disease Development
  • Pathologic Findings Postmortem in Narcolepsy Type 1
  • Immune System Chances in Narcolepsy Type 1 Patients
  • Circulating cytokines
  • Autoantibodies
  • T cells
  • Animal Models of Narcolepsy Type 1.
  • Is Narcolepsy Type 1 an Autoimmune Disease?
  • References
  • Chapter 13: Neuromyelitis optica, aquaporin-4 antibodies, and neuroendocrine disorders
  • Neuromyelitis Optica Spectrum Disorders
  • Introduction
  • Epidemiological, clinical, and radiological features of AQP4-IgG NMOSD
  • Circumventricular Organs and the Hypothalamus as Target of Aquaporin-4 Autoimmunity
  • Aquaporin-4 expression and function in the hypothalamus
  • The Spectrum of Neuroendocrine Disorders in Neuromyelitis Optica
  • Syndrome of inappropriate antidiuresis
  • Sleep disorders
  • Other endocrinopathies caused by hypothalamic involvement in NMOSD
  • Treatment of NMOSD
  • References
  • Chapter 14: Antibodies against the pituitary and hypothalamus in boxers
  • Traumatic Brain Injury: Epidemiology, Causes, and Outcomes
  • TBI and Neuroendocrine Abnormalities
  • Autoimmunity and Hypothalamo-Pituitary Dysfunction
  • Boxing and Autoimmunity
  • Acknowledgment
  • References
  • Chapter 15: Autoimmune diabetes insipidus
  • Introduction1
  • Autoantibody Studies
  • Vasopressin cell antibodies in the diagnosis of autoimmune DI
  • Autoantibodies to rabphilin-3A, a major target autoantigen in autoimmune DI
  • Comparison of cytoplasmic AVPcAb and autoantibodies to rabphilin-3A
  • Association of autoimmune DI with endocrine autoimmune diseases
  • AVPcAb and antibodies to rabphilin-3A in normal individuals without diabetes insipidus
  • Imaging: MRI of the brain and the pituitary gland, and FDG-PET
  • Relevance of AVPcAb and pituitary stalk thickening for the diagnosis of autoimmune DI
  • Immunohistochemical studies
  • The clinical picture of autoimmune DI
  • Association of lymphocytic infundibuloneurohypophysitis with lymphocytic anterior hypophysitis
  • Natural course of autoimmune DI/LINH
  • Treatment of autoimmune CDI/LINH
  • Autoimmune DI following therapy with immune checkpoint inhibitors.

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