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Zika virus biology, transmission, and pathology. Volume 1, The neuroscience of Zika /
| Cote: | Libro Electrónico |
|---|---|
| Autres auteurs: | , , , |
| Format: | Électronique eBook |
| Langue: | Inglés |
| Publié: |
London :
Academic Press,
2021.
|
| Sujets: | |
| Accès en ligne: | Texto completo |
Table des matières:
- Intro
- Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika Virus
- Copyright
- Dedication
- Contents
- Contributors
- Foreword
- Preface
- Section A: Zika virus: Introductory chapters
- Chapter 1: Flaviviruses and where the Zika virus fits in: An overview
- Classification, diversity, and evolution
- Biology of transmission and persistence of MBF and TBF
- Virion structure, genome, and viral protein function
- Viral infection and replication cycle
- Host infection, immune response, and pathogenesis
- Flavivirus emergence and global burden
- Emergence of Aedes-borne flaviviruses
- Emergence of Culex-borne flaviviruses
- Policy and procedures
- Vector-borne flaviviruses diagnoses
- Mini-dictionary of terms
- Key facts of flavivirus genera
- Summary points
- References
- Chapter 2: The innate immune response during Zika virus infection
- Introduction
- Importance of pattern recognition receptors (PRRs) in sensing ZIKV
- Type I interferon in ZIKV infection
- Innate immunity against ZIKV in the skin
- Innate immunity against ZIKV in the placenta
- Innate immunity against ZIKV in the brain
- Involvement of autophagy
- Innate immunity evasion by ZIKV
- Policy and procedures
- mRNA expression of innate immune receptors determined by real time PCR
- Measuring innate immune receptors protein expression by flow cytometry
- Analyzing innate immune receptors localization and function
- Mini-dictionary of terms
- Key facts of innate immune response in ZIKV infection
- Summary points
- References
- Chapter 3: The public health perspective of Zika virus infection
- Introduction
- Timeline of the outbreaks
- Epidemiology: Distribution and determinants
- Geographical distribution
- Epidemiological determinants
- Public health consequences
- Prevention and control of Zika virus infections.
- Better and sustained preparedness
- Implementation of strategic response framework
- Strengthening of International Health Regulations: Advice to travelers
- Strengthening of the sexual and reproductive health services
- Vector control, surveillance, risk communication, and promotion of research
- Bridging the gap between social and health inequalities
- Conclusion
- Policy and procedures
- Mini-dictionary of terms
- Key facts of the Zika virus infections
- Summary points
- References
- Chapter 4: Inequality in Zika virus and congenital Zika syndrome
- Inequalities in health
- The macro-drivers of the ZIKV
- Socioeconomic inequality in the prevalence of CZS
- Inequality in the exposure to ZIKV
- Inequality in susceptibility to the effect of ZIKV on CZS
- Sources of differential susceptibility
- Inequality in vector density
- Inequality in the vulnerability to the effect of vector density on ZIKV incidence
- The fundamental determination of ZIKV inequalities
- Socioeconomic implications
- Major knowledge gaps
- Policies to tackle the inequalities
- Mini-dictionary of terms
- Key facts
- Summary points
- References
- Chapter 5: Lifestyle factors and congenital Zika syndrome: Drugs, alcohol, and beyond
- Introduction
- Socioeconomic condition
- Lifestyle
- Access to information/health education
- Health-care access
- Abortion legislation
- Human rights
- Policy and procedures
- Multidisciplinary follow-up
- Multicenter follow-up of cohorts
- Mini-dictionary of terms
- Key facts
- Key facts of birth control methods
- Key facts of causes of mal formation in newborns
- Summary points
- References
- Chapter 6: Economic impact of Zika virus infection and associated conditions
- Introduction
- Brief history of ZIKV
- Health economics
- Economic and social impacts of recent outbreaks.
- The cost of vector control
- The cost of diagnosis
- The cost of ZIKV-associated microcephaly
- The cost of congenital Zika syndrome
- The costs of ZIKV-associated Guillain-Barr�e syndrome
- Understand the economic evaluation of health technologies
- Economic evaluation of current and emerging health technologies
- Policy and procedures
- Mini-dictionary of terms
- Key facts
- Summary points
- References
- Chapter 7: Health promotion, health education, and risk communication for Zika virus disease
- Health promotion and education program during a noncrisis situation
- Social assessment
- Epidemiological assessment
- Educational and ecological assessment
- Administrative and policy assessment and intervention alignment phase
- Implementation
- Process evaluation
- Impact evaluation
- Outcome evaluation
- Risk communication for Zika virus disease
- Mini-dictionary of terms
- Key facts of Zika virus disease or ZVD
- Summary points
- References
- Chapter 8: Molecular mechanisms of Zika virus-induced neurological pathology
- Introduction
- ZIKV impairs mitotic spindle assembly
- Premature neural progenitor cell differentiation during ZIKV infection decreases the number of mature neurons
- ZIKV induces apoptosis in infected and bystander cells
- ZIKV interferes with developmental gene expression programs
- Neuroinflammation
- Conclusions and outstanding questions
- Policy and procedures: Measuring apoptosis
- Mini-dictionary of terms
- Key facts of the unfolded protein response
- Summary points
- References
- Chapter 9: Validation of Zika virus infections: Nonmolecular aspects, immunoassays, and beyond
- Introduction
- Symptoms and diagnosis of ZIKV infection: Basics and guidance
- Serological methods used in diagnosing ZIKV infection
- Basics about ZIKV antibody detection
- Methods for detecting ZIKV antibodies.
- Virus neutralization assays
- Hemagglutination inhibition and immunofluorescence assays
- Immunoassays for detecting anti-ZIKV IgM, IgG, and IgA antibodies
- Policy and procedures
- DENV vaccine
- Mini-dictionary of terms
- Key facts of immunoassays used for the diagnosis of ZIKV infection
- Summary points
- References
- Chapter 10: Validation of Zika virus infections: A focus on molecular methods
- Introduction
- Molecular methods: ZIKV nucleic acids
- Basics of the nucleic acid amplification tests (NAATs)
- Real-time RT-PCRs
- Multiplex real-time RT-PCRs
- Conventional RT-PCRs
- Validation criteria
- Policy and procedures
- Mini-dictionary of the terms
- Key facts of molecular tests used for diagnosis of ZIKV infection
- Summary points
- References
- Chapter 11: Coinfection of Zika with Dengue and Chikungunya virus
- Introduction
- Timeline of coinfections
- Distribution of coinfections
- Detection of arboviruses in coinfections
- Clinical outcomes of coinfections
- Coinfection with ZIKV and DENV
- Coinfection with ZIKV and CHIKV
- Triple coinfection with ZIKV, DENV, and CHIKV
- Conclusion
- Policy and procedures
- Mini-dictionary of terms
- Key facts
- Summary points
- References
- Chapter 12: Zika virus, pathology, and control: Zika vaccine strategies in development
- Introduction
- Adaptive immunity to ZIKV infection
- The humoral immune response to ZIKV
- The T-cell immune response to ZIKV
- Key challenges facing Zika vaccine development
- Target populations for ZIKV vaccination
- The protection afforded by ZIKV vaccination
- Zika vaccine platforms
- Whole virus-based vaccines
- Subunit virus-based vaccines
- Clinical evaluation of Zika vaccine candidates
- Concluding remarks
- Policy and procedures
- Mini-dictionary of terms
- Key facts on Zika vaccine
- Summary points
- References.
- Section B: Effects on neurological and body systems
- Chapter 13: The adult brain and neurologic manifestations of the Zika virus
- Introduction
- Zika virus and the nervous system: NeuroZika
- Guillain-Barr�e syndrome
- ZIKV-GBS viral diagnosis
- ZIKV-GBS neuroimaging
- GBS-Zika virus treatment and prognosis
- Others neurological complications
- General implications
- Policy and procedures
- Using the Brighton collaboration GBS working group criteria for GBS diagnosis
- Mini-dictionary of terms
- Key facts of NeuroZika
- Summary points
- References
- Chapter 14: Postmortem studies: Contribution to understand the pathogenesis of congenital Zika syndrome
- Introduction
- Pathogenesis of the lesions in CZS
- Conclusions
- Policy and procedures
- Mini-dictionary of terms
- Key facts
- Key facts of congenital Zika syndrome (CZS)
- Summary points
- References
- Chapter 15: Developmental trajectories in infants and toddlers born with congenital Zika syndrome
- Introduction
- Zika virus and the developing brain
- Congenital Zika syndrome
- Motor development
- Cognitive development
- Communication skills
- General implications
- Policy and procedures
- Measuring head circumference
- Using standardized tests to evaluate developmental skills in infants with CZS
- Mini-dictionary of terms
- Key facts
- Summary points
- References
- Chapter 16: Host genetic susceptibility to ZIKV congenital syndrome: A tale of twins
- Introduction
- Zika virus in Brazil
- Congenital Zika syndrome: Reasons for studying ZIKV effects in humans
- Risks for ZIKV-associated microcephaly and other CZS symptoms
- Twins: A powerful tool for investigating risks for ZIKV-associated microcephaly and CZS
- Twins cells are differentially infected by ZIKV
- Investigating the molecular NPCs twins differences
- Conclusion and follow-up.