Discovery and development of anti-breast cancer agents from natural products /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Brahmachari, Goutam (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Elsevier, 2021.
Colección:Natural product drug discovery
Temas:
Antineoplastic agents > Development.
Breast > Cancer > Chemotherapy.
Natural products.
Sein > Cancer > Chimioth�erapie.
Produits naturels.
Antineoplastic agents > Development
Breast > Cancer > Chemotherapy
Natural products
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title
  • Copyright
  • Dedication
  • Contents
  • Contributors
  • Editor's Biography
  • Forewords
  • Preface
  • Chapter 1
  • Discovery and Development of Anti-Breast Cancer Agents From Natural Products: An Overview
  • 1
  • Introduction
  • 2
  • An overview of the book
  • 2.1
  • Chapter 2
  • 2.2
  • Chapter 3
  • 2.3
  • Chapter 4
  • 2.4
  • Chapter 5
  • 2.5
  • Chapter 6
  • 2.6
  • Chapter 7
  • 2.7
  • Chapter 8
  • 2.8
  • Chapter 9
  • 2.9
  • Chapter 10
  • 2.10
  • Chapter 11
  • 3
  • Concluding remarks
  • Chapter 2
  • Epothilones A and B: The 16-Membered Natural Macrolides as a Fascinating Template for Antibreast Cancer Drug Di...
  • 1
  • Introduction
  • 2
  • Epothilones A and B: production and isolation, physical and spectral properties, anticancer potential, and mechanism of...
  • 2.1
  • Production and isolation
  • 2.2
  • Physical and spectral properties
  • 2.2.1
  • Epothilone A (1)
  • 2.2.2
  • Epothilone B (2)
  • 2.3
  • Anticancer potential and mechanism of drug action
  • 2.3.1
  • Anticancer potential
  • 2.3.2
  • Mechanism of drug action
  • 2.3.3
  • Structure-activity relationships (SARs) for epothilones
  • 3
  • The epothilone template: role in anticancer drug discovery
  • 4
  • Concluding remarks
  • References
  • Chapter 3
  • Anti-Breast Cancer Terpenoids of Natural Origins
  • 1
  • Introduction
  • 1.1
  • Causes of breast cancer
  • 1.2
  • Types of breast cancers
  • 1.3
  • Breast cancer biomarkers
  • 1.4
  • Clinical diagnosis
  • 1.5
  • Stages of breast cancer
  • 1.6
  • Treatment options
  • 2
  • Role of natural products in breast cancer treatment
  • 2.1
  • Terpenes as anti-breast cancer agents
  • 2.2
  • Sesquiterpenoids as anti-breast cancer agents
  • 2.3
  • Diterpenoids as anti-breast cancer agents
  • 2.3.1
  • Paclitaxel as a clinical drug against breast cancer
  • 2.3.2
  • Structure-activity relationships (SARs) of paclitaxel
  • 2.4
  • Triterpenoids as anti-breast cancer agents
  • 2.4.1
  • Ursolic acid as anti-breast cancer agent
  • 2.4.2
  • Cucurbitacins as anticancer agents against breast cancer
  • 3
  • Future prospects
  • 4
  • Concluding remarks
  • Abbreviations
  • References
  • Chapter 4
  • Vinca Alkaloids as Chemotherapeutic Agents Against Breast Cancer
  • 1
  • Introduction: an overview of breast cancer
  • 2
  • Vinca alkaloids: general features, sources, and ethnopharmacological relevance
  • 2.1
  • Vinblastine (originally known as vincaleucoblastine)
  • 2.2
  • Vincristine (originally known as leurocristine)
  • 2.3
  • Vinorelbine
  • 2.4
  • Vindesine
  • 2.5
  • Vinflunine
  • 3
  • Isolation and characterization of vinca alkaloids
  • 4
  • Mechanism of action of vinca alkaloids cytotoxicity
  • 5
  • Preclinical studies: in vitro and animal research on the anti-breast activities of vinca alkaloids and its derivatives
  • 6
  • Breast cancer clinical trials: the role of vinca alkaloids and derivatives
  • 7
  • Commercial vinca alkaloids: pharmacokinetics, toxicity/adverse reactions and interactions
  • 7.1
  • Pharmacokinetics

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