Human aging : from cellular mechanisms to therapeutic strategies /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Carudo, Calogero (Editor ), Candore, Giuseppina (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, United Kingdom : Academic Press, 2021.
Temas:
Aging.
Age factors in disease.
Aging
Age Factors
Vieillissement.
Maladies > Facteurs li�es �a l'�age.
Age factors in disease
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Human Aging: From Cellular Mechanisms to Therapeutic Strategies
  • Copyright
  • Contents
  • Contributors
  • About the editors
  • Preface
  • Chapter 1: Aging and longevity: An evolutionary approach
  • 1.1. Introduction
  • 1.2. Why does aging occur?
  • 1.3. Mechanisms of aging
  • 1.4. Causality and chance in aging and longevity
  • 1.5. Conclusions and future perspectives
  • References
  • Chapter 2: Demographic aspects of aging
  • 2.1. Introduction
  • 2.2. Understanding the process: Browsing around the demographic transition theories
  • 2.3. Aging inequalities
  • 2.3.1. Differences by gender, education, and cause of death
  • 2.3.2. Does having a longer life also mean having a better life?
  • 2.3.3. Economics of population aging
  • 2.4. Conclusions and perspectives
  • References
  • Chapter 3: Pathobiology of aging: An introduction to age-related diseases
  • 3.1. Introduction
  • 3.2. Complexity
  • 3.3. Hallmarks of aging
  • 3.4. Genomic instability
  • 3.5. Epigenetic alteration
  • 3.6. Deregulated nutrient sensing pathways
  • 3.6.1. FOXO3
  • 3.6.2. Insulin/IGF-1 pathway
  • 3.6.3. mTOR pathway
  • 3.6.4. Sirtuin pathway
  • 3.6.5. Autophagy
  • 3.7. Loss of proteostasis
  • 3.8. Mitochondrial dysfunction
  • 3.9. Telomere attrition
  • 3.10. Cellular senescence
  • 3.11. Stem cell exhaustion
  • 3.12. Altered intercellular communication
  • 3.13. Cancer and aging
  • 3.14. Conclusion and future perspectives
  • References
  • Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
  • 4.1. Introduction
  • 4.2. Signaling pathway stimulating the appearance of SASP
  • 4.3. SASP components
  • 4.4. MiRNA and extracellular vesicles as new regulators and components of SASP
  • 4.5. SASP profile in different cell types
  • 4.6. Cellular senescence, SASP, and aging
  • 4.7. Conclusions and future perspectives
  • References
  • Chapter 5: The role of inflammaging in the development of chronic diseases of older people
  • 5.1. Introduction
  • 5.2. Basic mechanisms: Cellular senescence, inflammaging, molecular inflammation, and senoinflammation
  • 5.2.1. Cellular senescence
  • 5.2.2. Inflammaging
  • 5.2.3. Molecular inflammation
  • 5.2.4. Senoinflammation
  • 5.3. Is chronic inflammatory state a common denominator of ARDs?
  • 5.3.1. T2DM
  • 5.3.2. Chronic aging-related respiratory diseases
  • 5.3.3. Atherosclerosis
  • 5.3.4. Frailty
  • 5.3.5. Alzheimer's disease (AD)
  • 5.3.6. Parkinson's disease (PD)
  • 5.4. The case of COVID-19
  • 5.5. Proposed interventions to prevent ARDs
  • 5.6. Conclusion and future perspective
  • References
  • Chapter 6: A new perspective on ROS in aging with an integrated view of the gut microbiota
  • 6.1. Introduction
  • 6.2. The reactive oxygen species
  • 6.3. The biological function of ROS
  • 6.4. The oxidative stress theory of aging

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