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|a 1250601846
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|a 9780128227374
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|z 9780128225691
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|z 0128225696
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|a (OCoLC)1251803624
|z (OCoLC)1250601846
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|a QP86
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|a 612.67
|2 23
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| 245 |
0 |
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|a Human aging :
|b from cellular mechanisms to therapeutic strategies /
|c edited by Calogero Caruso and Giuseppina Candore.
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| 264 |
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1 |
|a London, United Kingdom :
|b Academic Press,
|c 2021.
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| 300 |
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|a 1 online resource (1 volume) :
|b illustrations (black and white, and color)
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 500 |
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|a Includes index.
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| 588 |
0 |
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|a Print version record.
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0 |
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|a Intro -- Human Aging: From Cellular Mechanisms to Therapeutic Strategies -- Copyright -- Contents -- Contributors -- About the editors -- Preface -- Chapter 1: Aging and longevity: An evolutionary approach -- 1.1. Introduction -- 1.2. Why does aging occur? -- 1.3. Mechanisms of aging -- 1.4. Causality and chance in aging and longevity -- 1.5. Conclusions and future perspectives -- References -- Chapter 2: Demographic aspects of aging -- 2.1. Introduction -- 2.2. Understanding the process: Browsing around the demographic transition theories -- 2.3. Aging inequalities
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| 505 |
8 |
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|a 2.3.1. Differences by gender, education, and cause of death -- 2.3.2. Does having a longer life also mean having a better life? -- 2.3.3. Economics of population aging -- 2.4. Conclusions and perspectives -- References -- Chapter 3: Pathobiology of aging: An introduction to age-related diseases -- 3.1. Introduction -- 3.2. Complexity -- 3.3. Hallmarks of aging -- 3.4. Genomic instability -- 3.5. Epigenetic alteration -- 3.6. Deregulated nutrient sensing pathways -- 3.6.1. FOXO3 -- 3.6.2. Insulin/IGF-1 pathway -- 3.6.3. mTOR pathway -- 3.6.4. Sirtuin pathway -- 3.6.5. Autophagy
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| 505 |
8 |
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|a 3.7. Loss of proteostasis -- 3.8. Mitochondrial dysfunction -- 3.9. Telomere attrition -- 3.10. Cellular senescence -- 3.11. Stem cell exhaustion -- 3.12. Altered intercellular communication -- 3.13. Cancer and aging -- 3.14. Conclusion and future perspectives -- References -- Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process -- 4.1. Introduction -- 4.2. Signaling pathway stimulating the appearance of SASP -- 4.3. SASP components -- 4.4. MiRNA and extracellular vesicles as new regulators and components of SASP
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| 505 |
8 |
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|a 4.5. SASP profile in different cell types -- 4.6. Cellular senescence, SASP, and aging -- 4.7. Conclusions and future perspectives -- References -- Chapter 5: The role of inflammaging in the development of chronic diseases of older people -- 5.1. Introduction -- 5.2. Basic mechanisms: Cellular senescence, inflammaging, molecular inflammation, and senoinflammation -- 5.2.1. Cellular senescence -- 5.2.2. Inflammaging -- 5.2.3. Molecular inflammation -- 5.2.4. Senoinflammation -- 5.3. Is chronic inflammatory state a common denominator of ARDs? -- 5.3.1. T2DM
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| 505 |
8 |
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|a 5.3.2. Chronic aging-related respiratory diseases -- 5.3.3. Atherosclerosis -- 5.3.4. Frailty -- 5.3.5. Alzheimer's disease (AD) -- 5.3.6. Parkinson's disease (PD) -- 5.4. The case of COVID-19 -- 5.5. Proposed interventions to prevent ARDs -- 5.6. Conclusion and future perspective -- References -- Chapter 6: A new perspective on ROS in aging with an integrated view of the gut microbiota -- 6.1. Introduction -- 6.2. The reactive oxygen species -- 6.3. The biological function of ROS -- 6.4. The oxidative stress theory of aging
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| 650 |
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0 |
|a Aging.
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| 650 |
|
0 |
|a Age factors in disease.
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| 650 |
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2 |
|a Aging
|0 (DNLM)D000375
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| 650 |
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2 |
|a Age Factors
|0 (DNLM)D000367
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| 650 |
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6 |
|a Vieillissement.
|0 (CaQQLa)201-0020292
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| 650 |
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6 |
|a Maladies
|x Facteurs li�es �a l'�age.
|0 (CaQQLa)201-0000226
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| 650 |
|
7 |
|a Age factors in disease
|2 fast
|0 (OCoLC)fst00800172
|
| 650 |
|
7 |
|a Aging
|2 fast
|0 (OCoLC)fst00800293
|
| 700 |
1 |
|
|a Carudo, Calogero,
|e editor.
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| 700 |
1 |
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|a Candore, Giuseppina,
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|t HUMAN AGING.
|d [Place of publication not identified] : ELSEVIER ACADEMIC PRESS, 2021
|z 0128225696
|w (OCoLC)1190853212
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| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128225691
|z Texto completo
|
