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|a 9780128245606
|q (electronic bk.)
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|a 0128245603
|q (electronic bk.)
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|z 9780128244302
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|z 0128244305
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|a (OCoLC)1250306437
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|a RA1057.5
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|a 614.1
|2 23
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1 |
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|a Vigeland, Magnus Dehli.
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| 245 |
1 |
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|a Pedigree analysis in R /
|c Magnus Dehli Vigeland.
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| 264 |
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1 |
|a London :
|b Academic Press,
|c 2021.
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| 300 |
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|a 1 online resource
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 505 |
8 |
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|a 4.2.3 Recombination Maps in ibdsim2 -- Built-in maps -- Uniform maps -- 4.3 Variation in Realised Coefficients -- 4.3.1 First-Cousin Inbreeding -- 4.3.2 Some Siblings Are More Equal Than Others -- 4.4 Distributions of IBD Segments -- 4.4.1 The Importance of Sex -- 4.4.2 Separating the Inseparable: H-U-G -- 4.5 The Probability of No IBD Sharing -- Chapter 5: Probabilities on Pedigrees -- 5.1 Computing Pedigree Likelihoods -- 5.1.1 Basic Likelihood Calculations -- 5.1.2 The General Likelihood Expression -- 5.1.3 The Elston-Stewart Algorithm -- 5.1.4 Likelihoods With pedprobr -- 5.2 Factors Affecting Performance -- 5.2.1 Allele Lumping -- 5.2.2 Pedigree Loops -- 5.3 Likelihoods With Linked Markers -- 5.3.1 Linked Markers in R: Two Markers -- 5.3.2 Linked Markers in R: More Than Two Markers -- 5.4 Modelling Mutations -- 5.4.1 Properties of Mutation Models -- Reversibility -- Lumpability -- 5.5 Modelling Deviation From HWE -- 5.5.1 Founder Inbreeding -- 5.5.2 Theta Correction -- Chapter 6: Kinship Testing -- 6.1 Theory and Methods -- 6.1.1 Kinship Testing vs. Classical Hypothesis Testing -- 6.1.2 The Likelihood Ratio -- 6.1.3 Alternatives to LR -- 6.1.4 Kinship Testing With forrel -- 6.2 Paternity Testing -- 6.2.1 Manual Calculation of \LR -- 6.2.2 Paternity Testing With forrel -- 6.2.3 Direct Computation of \LR -- 6.3 A Relationship Riddle -- 6.4 Missing Person Identification -- 6.4.1 Terminology and Hypotheses -- 6.4.2 A Case Study -- 6.5 Power Analysis for Kinship Testing -- 6.5.1 Exclusion Power -- 6.5.2 Inclusion Power -- 6.5.3 Power Analysis for Missing Person Cases -- 6.6 Dealing With Mutations -- Chapter 7: Inference of Pairwise Relatedness -- 7.1 Maximum-Likelihood Estimation of Kappa -- 7.1.1 The Likelihood Function -- 7.1.2 The Maximum-Likelihood Estimate -- 7.1.3 Inadmissible Estimates?
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|a 7.1.4 What About the Kinship Coefficient? -- 7.2 Estimation of Identity Coefficients -- 7.3 ML Estimation in forrel -- 7.3.1 Example: The Relationship Riddle -- 7.3.2 Confidence and Uncertainty -- 7.4 Quality Control of Pedigree Data -- 7.5 Violating the Assumptions -- 7.5.1 Inaccurate Allele Frequencies -- 7.5.2 Linkage Between Markers -- 7.5.3 Inbreeding -- Chapter 8: Pedigree Reconstruction -- 8.1 Reconstruction by Pairwise Inference -- 8.2 Maximum-Likelihood Pedigree Reconstruction -- 8.2.1 Restrictions on the Space of Pedigrees -- 8.2.2 Solving the Relationship Riddle -- Chapter 9: Linkage Analysis -- 9.1 Theoretical Background -- 9.1.1 Hypothesis Testing and the LOD Score -- Example -- 9.1.2 Unknown Phase -- 9.1.3 Parametric Disease Models -- 9.1.4 What Is a Significant LOD Score? -- 9.1.5 Multipoint Analysis -- 9.1.6 Power Assessment -- 9.2 LOD Scores in paramlink2 -- 9.2.1 An X-Linked Example -- 9.2.2 More About the lod() Function -- Disease Models -- 9.3 A Case Study -- 9.3.1 Power Assessment -- 9.3.2 Loading the Data -- 9.3.3 Quality Control -- 9.3.4 Disease Model and Preliminary Analysis -- 9.3.5 Multipoint Analysis -- 9.3.6 Liability Classes -- 9.3.7 Summarising LOD Peaks -- Chapter 10: Segregation Analysis for Variant Interpretation -- 10.1 Background -- 10.2 The Bayes Factor -- 10.2.1 Using the Bayes Factor in the ACMG Framework -- 10.3 Bayes Factors With the segregatr Package -- 10.4 A Case Study -- Bibliography.
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| 650 |
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0 |
|a Forensic genetics
|x Data processing.
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| 650 |
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0 |
|a Medical genetics
|x Data processing.
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| 650 |
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0 |
|a R (Computer program language)
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| 650 |
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6 |
|a G�en�etique l�egale
|0 (CaQQLa)201-0186718
|x Informatique.
|0 (CaQQLa)201-0380011
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| 650 |
|
6 |
|a G�en�etique m�edicale
|0 (CaQQLa)201-0001432
|x Informatique.
|0 (CaQQLa)201-0380011
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| 650 |
|
6 |
|a R (Langage de programmation)
|0 (CaQQLa)201-0368319
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| 650 |
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7 |
|a R (Computer program language)
|2 fast
|0 (OCoLC)fst01086207
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| 776 |
0 |
8 |
|i Print version:
|z 0128244305
|z 9780128244302
|w (OCoLC)1181846228
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| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128244302
|z Texto completo
|
