Handbook on nanobiomaterials for therapeutics and diagnostic applications /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Anand, Krishnan, Saravanan, Muthupandian, 1977-, Chandrasekaran, Balakumar, Kanchi, Suvardhan, Panchu, Sarojini Jeeva, Chen, Quan-Sheng
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Elsevier, 2021.
Temas:
Biomedical materials.
Nanostructured materials.
Nanobiotechnology.
Nanostructures
Biomat�eriaux.
Nanomat�eriaux.
Nanobiotechnologie.
Handbook
Handbooks and manuals.
Guides et manuels.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Handbook on Nanobiomaterials For Therapeutics and Diagnostic Applications
  • Copyright
  • Contents
  • Contributors
  • Chapter 1 Nanosomes for drug delivery
  • 1.1 Introduction
  • 1.2 Drug delivery system
  • 1.3 Pharmacokinetics and pharmacodynamics
  • 1.4 Types of nanosomes in drug delivery
  • 1.4.1 Endosomes in drug delivery
  • 1.4.2 Exosomes in drug delivery
  • 1.4.3 Liposomes in drug delivery
  • 1.4.4 siRNA-encapsulated nanosomes in drug delivery
  • 1.4.4.1 Epidemiology
  • 1.5 Nanosomes and gene therapy
  • 1.6 Nanosome transportation mechanisms
  • 1.7 Blockades of nanosome trafficking
  • 1.8 Drug release
  • 1.9 Conclusion
  • References
  • Chapter 2 Nanomaterials for bioimaging studies
  • 2.1 Introduction
  • 2.2 Dye-loaded fluorescent silica nanoparticles (SiNPs) in bioimaging
  • 2.2.1 Properties of SiNPs
  • 2.2.2 Synthesis of SiNPs
  • 2.2.3 Bioimaging
  • 2.2.3.1 Typical fluorescent dye-doped SiNPs
  • 2.2.3.2 Near-infrared fluorescent dye-doped SiNPs
  • 2.2.3.3 Two-photon fluorescent dye silica nanoparticles
  • 2.3 Imaging, targeting, and drug delivery using multifunctional inorganic nanoparticles (MiNPs)
  • 2.4 Lanthanide-doped upconverting nanoparticles
  • 2.4.1 The fundamental mechanism of UCNPs
  • 2.4.2 Synthesis of UCNPs
  • 2.4.3 UCNPs as image contrasting agents
  • 2.5 Conclusions
  • References
  • Chapter 3 Exosome RNAs as biomarkers for cancer therapy
  • 3.1 Introduction
  • 3.2 Exosomes in cancer
  • 3.3 Exosomes from body fluids
  • 3.3.1 Resistance to cancer therapeutics
  • 3.3.2 Nanodiagnostic exosomes by electrochemical biosensing
  • 3.3.3 Characterization of salivary exosomes
  • 3.4 Exosomes derived from tumor cells
  • 3.4.1 Role of exosomes in metastasis of cancer cells
  • 3.4.2 State of exosomes within the enlargement of cancer tissue amidst angiogenesis
  • 3.5 Exosomes-Role in maintaining a strategic distance from an assault from immune cells
  • 3.6 Potential benefits of exosomal RNAs in malignant growth diagnostics and treatment
  • 3.6.1 Exosomal ncRNAs as malignancy indicative biomarkers
  • 3.6.2 Uses of exosomal noncoding RNAs (ncRNAs) as cancer therapeutics
  • 3.7 Conclusion
  • References
  • Chapter 4 Tumoral delivery of nanotherapeutics
  • 4.1 Introduction
  • 4.2 Therapeutics employed for tumor treatment
  • 4.2.1 Chemotherapy
  • 4.2.2 Genetic material
  • 4.2.3 Photodynamic therapy (PDT)
  • 4.2.4 Photothermal therapy (PTT)
  • 4.2.5 Immunotherapy
  • 4.2.6 Sonodynamic therapy
  • 4.3 Barriers to tumoral delivery of nanotherapeutics
  • 4.3.1 Barriers in the systemic circulation
  • 4.3.2 Barriers in the tumor microenvironment
  • 4.3.3 Barriers at cellular level
  • 4.3.4 Heterogeneity in vascular density among different tumors
  • 4.4 Potential of nanocarriers for tumoral delivery of therapeutics
  • 4.4.1 Chemotherapy
  • 4.4.2 Gene therapy
  • 4.4.3 PDT
  • 4.4.4 PTT
  • 4.4.5 Combination therapy
  • 4.4.6 Targeted therapy
  • 4.4.6.1 Passive targeting

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