Mechanistic approach to medicines for tuberculosis nanotherapy /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Rajan, Mariappan
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, 2021.
Temas:
Tuberculosis > Treatment.
Nanomedicine.
Tuberculosis.
Tuberculosis
Tuberculosis > therapy
Nanomedicine > methods
Nanomedicine
Tuberculose > Traitement.
Tuberculose.
Nanom�edecine.
Tuberculosis > Treatment
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy
  • Copyright
  • Contents
  • Contributors
  • Chapter 1 Basics of tuberculosis disease and principles of treatment and their effects
  • 1 Introduction
  • 2 Host response to Mtb infection
  • 3 Role of innate immune cells against Mtb infection
  • 3.1 Macrophage
  • 3.2 Neutrophil
  • 3.3 Dendritic cell
  • 3.4 Natural killer cells
  • 4 Immune factors involved in Mtb recognition
  • 4.1 Complement factors and complement receptors
  • 4.2 Mannose receptor
  • 4.3 Collectins
  • 4.4 Toll-like receptors
  • 7 Adaptive immune response against TB infection
  • 7.1 Humoral response to TB infection
  • 7.2 Cell-mediated response to TB infection
  • 8 Immune evasion strategy by Mycobacterium tuberculosis
  • 9 Treatment for tuberculosis infection and side effects
  • 10 Drug-resistant TB
  • 10.1 Types of drug-resistant TB
  • 11 TB diagnosis
  • 11.1 Smear microscopy
  • 11.2 Culture methods and drug susceptibility testing
  • 11.3 Molecular diagnosis
  • 11.4 GeneXpert MTB/RIF
  • 11.5 Line probe assays
  • 11.6 Sequencing
  • 12 Diagnosis of latent TB infection
  • 13 Conclusion
  • References
  • Chapter 2 The pulmonary administration route: Advantages and challenges
  • 1 Introduction
  • 1.1 Transmission and pathogenesis of TB bacteria
  • 1.2 Current therapeutics for treating TB and their limitations
  • 2 Pulmonary drug delivery system (PDDS)
  • 2.1 Lung as an attractive target for pulmonary drug delivery
  • 2.2 Administration and deposition of inhaled particles on the lung
  • 2.3 Clearance mechanism of the administrated particles in the pulmonary system
  • 2.3.1 Mucociliary clearance
  • 2.3.2 Alveolar clearance
  • 3 Pulmonary drug administration
  • 3.1 Drug delivery systems
  • 3.1.1 Liposomes
  • 3.1.2 Proliposomes
  • 3.1.3 Liposphere
  • 3.1.4 Nanocarrier systems
  • 3.1.5 Polymeric nanoparticles
  • 3.1.6 Polymeric micelles
  • 4 Advantages of the pulmonary administration route
  • 5 Current advances in pulmonary drug delivery
  • 6 Factors affecting pulmonary drug delivery
  • 6.1 Physical factors affecting aerosol deposition
  • 6.1.1 Inspiratory
  • 6.1.2 Aerosol generation
  • 6.1.3 Tidal volume
  • 6.1.4 Breath
  • 6.1.5 Disease states
  • 6.2 Pharmaceutical factors affecting aerosol deposition
  • 6.2.1 Aerosol
  • 6.2.2 Size
  • 6.2.3 Shape
  • 6.2.4 Density

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