The cancer stem cell niche /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Nilsson, Susie (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2021.
Colección:Advances in stem cells and their niches ; volume 5.
Temas:
Stem cells.
Cancer cells.
Stem Cells
Cellules souches.
Cellules canc�ereuses.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • The Cancer Stem Cell Niche
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Acute lymphoblastic leukemia and the bone marrow microenvironment
  • 1. Introduction
  • 2. Cellular components of the ALL niche
  • 2.1. Osteoblasts and osteoclasts
  • 2.2. Mesenchymal stem/stromal cells (MSC)
  • 2.3. Endothelial cells
  • 2.4. Regulatory T-cells
  • 2.5. Central nervous system (CNS)
  • 3. Extracellular components of the ALL niche
  • 3.1. Cytokines
  • 3.2. Extracellular matrix (ECM) molecules
  • 3.3. Oxygen/hypoxia/reactive oxygen species (ROS)
  • 3.4. Metal ions
  • 4. Summary
  • Acknowledgments
  • Conflicts of interest
  • References
  • Chapter Two: Stem cell niches in bone and their roles in cancer metastasis
  • 1. Introduction
  • 2. Niches within the bone marrow
  • 3. Niche constituents originating from mesenchymal stem cells
  • 3.1. Osteoblasts
  • 3.2. Osteocytes
  • 3.3. Bone marrow adipocytes
  • 4. Niche constituents originating from hematopoietic stem cells
  • 4.1. Osteoclasts
  • 4.2. Immune cells
  • 5. Other niche constituent cell types
  • 5.1. Endothelial cells
  • 5.2. Nerves
  • 5.3. Megakaryocytes and platelets
  • 6. Future perspectives
  • References
  • Chapter Three: The role of vasculature in cancer stem cell niches
  • 1. Introduction
  • 2. Niche functions of vasculature
  • 3. Links between vasculature and cancer cell stemness
  • 4. Angiocrine crosstalk in the tumor microenvironment
  • 5. Maladaptation of vasculature in the tumor microenvironment
  • 6. Vascular microenvironments supporting the cancer stem cell quiescence
  • 7. Vascular niches for disseminated tumor cells and CSCs in the bone marrow
  • 8. Conclusions
  • References
  • Chapter Four: The lung cancer stem cell niche
  • 1. Introduction
  • 2. Epithelial stem cell compartments in the adult lung
  • 2.1. Developmental origins and regulation of the lung epithelial stem cell hierarchy
  • 2.2. Stem and progenitor cells of the proximal airways
  • 2.3. Stem and progenitor cells of the distal airways
  • 2.4. Stem and progenitor cells of the alveolar bed
  • 2.5. Lung stem and progenitor cell plasticity
  • 2.6. Human lung stem cell homologs
  • 3. Lung cancer stem cells
  • 3.1. Non-small cell lung cancer
  • 3.2. Small cell lung cancer
  • 4. Deconstructing the lung cancer stem cell niche
  • 4.1. Field of injury and field cancerization

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