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Organ repair and regeneration : preserving organs in the regenerative medicine era /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2021.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover
- ORGAN REPAIR AND REGENERATION
- ORGAN REPAIR AND REGENERATIONPRESERVING ORGANS IN THE REGENERATIVE MEDICINE ERAEDITED BYGIUSEPPE ORLANDO, MD, PHDMARIE CURI ...
- Copyright
- Contents
- Contributors
- Foreword
- Preface
- 1
- Ischemia-reperfusion injury
- Concepts and molecular mechanisms of ischemia reperfusion injury
- Fundamental concept of ischemia-reperfusion injury
- Causes of ischemia-reperfusion injury
- Reactive oxygen species in ischemia-reperfusion injury
- Cell death pathways in ischemia-reperfusion injury
- Necrosis and necroptosis
- Pyroptosis
- Apoptosis and autophagy
- Danger signals: the link between cell death to inflammation
- Danger-associated molecular patterns
- Pattern recognition receptors
- DAMP and PRR interaction-cell signaling
- DAMP and PRR interaction-inflammasome formation
- Cellular inflammation in ischemia-reperfusion injury
- Innate immune response
- Adaptive immune response
- Ischemia-reperfusion injury in acute kidney injury and transplantation
- Acute kidney injury and delayed graft function-definitions and implications
- Delayed graft function-an important subset of acute kidney injury in transplantation
- Clinical studies investigating ischemia-reperfusion injury in DGF and AKI
- Preclinical research in renal ischemia-reperfusion injury
- Renal IRI model-animal selection
- Renal IRI model-surgical considerations
- Renal IRI model-quantification and analysis
- Limitations of the histological scoring system-human and animal studies
- Additional application-pancreatic and islet IRI
- Future directions
- References
- 2
- Machine perfusion for donor organ repair: from vision to everyday clinical practice
- Strategies for donor pool expansion
- Machine perfusion and liver anatomy
- Machine perfusion
- Liver anatomy and histology for machine perfusion
- Extrahepatic vessels
- Liver parenchyma
- Biliary system
- Mechanisms of preservation injury and graft protection
- Ischemia/reperfusion injury
- Bile duct injury
- Sinusoidal endothelial injury
- Graft viability assessment
- Vascular resistance
- Damage markers
- Energy metabolism
- Bile examination
- Clinical practices of ex situ machine perfusion
- Episode zero
- HMP
- HOPE and DHOPE
- NMP
- Viability assessment
- Combined HOPE and NMP
- References
- 3
- Assessing and reconditioning kidneys using normothermic machine perfusion
- Introduction
- Development of NMP for renal grafts
- Perfusion solutions
- Acellular perfusates
- Blood-based perfusates
- Clinical normothermic machine perfusion
- Quality assessment and conditioning
- Repair mechanisms and potential for reconditioning
- Ischemia reperfusion injury
- Reversal of ischemia reperfusion injury
- Future developments
- Conclusion
- References
- Further reading
- 4
- Autologous cells for renal allograft repair
- Introduction