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Cancer : oxidative stress and dietary antioxidants /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2021.
|
| Edición: | Second edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Cancer: Oxidative Stress and Dietary Antioxidants
- Copyright
- Preface
- Contents
- Contributors
- Section A: Oxidative stress and cancer
- Chapter 1: Paraoxonases, oxidative stress, and breast cancer
- Introduction
- Functions and physiological roles of PON1
- PON1 and cancer: Focusing on breast cancer
- PON1 signaling pathways
- PON1 polymorphisms
- Function and physiological roles of PON2 and PON3
- PON2/3 and cancer: Focusing on breast cancer
- PON2 signaling pathways
- PON3 signaling pathways
- PON2/3 polymorphisms
- The paradox: PON activities and BC development
- Concluding remarks
- Application to other cancers
- Summary points
- References
- Chapter 2: Oxidative stress and prostate cancer
- Introduction
- Causes of oxidative stress in prostate cancer
- Increased ROS production
- Altered mitochondrial bioenergetics
- Upregulation of Nox enzymes
- Upregulation of COX enzymes
- Hypoxia
- Impaired antioxidant defenses
- Altered antioxidant enzymes
- Altered transcriptional factors related to the redox balance
- Role of oxidative stress in the pathogenesis of prostate cancer
- Oxidative stress in carcinogenesis and cancer progression
- Oxidative stress in castration resistance
- Oxidative stress in resistance to other therapeutics
- Prostate cancer risk factors and their links to oxidative stress
- Aging
- Genetic background (race and family history)
- Androgens
- Inflammation
- Diet
- Lifestyle
- Conclusions
- Applications to other cancers or conditions
- Summary points
- References
- Chapter 3: Oxidative stress in lung cancer
- Introduction
- Lung cancer
- Etiology of lung cancer
- Tobacco smoking
- Air pollution
- Infection and inflammation
- Radon
- Genetics
- Tobacco smoking and oxidants
- Silica and oxidants
- Asbestos and oxidants
- MicroRNAs and oxidative stress
- Radon and oxidative stress
- Inflammation and oxidative stress
- Oxidative stress leads to DNA mutations and lung cancer
- Lipid and protein peroxidation
- Antioxidants and lung cancer prevention
- Conclusion
- Summary points
- References
- Chapter 4: Endogenous antioxidants in the prognosis and treatment of lung cancer
- Double-edged sword of antioxidants in cancer
- Nrf2: Transcriptional regulator of the redox balance
- Role of Nrf2
- Nrf2 in NSCLC
- Nrf2-mediated chemoresistance and therapeutic strategies
- Glutathione and thioredoxin antioxidant systems
- GSH system
- GSH system in NSCLC
- Therapeutic strategies
- Trx system
- Trx system in NSCLC
- Therapeutic strategies
- Dual targeting of the Trx and GSH systems
- Application to other cancers
- Summary points
- References
- Chapter 5: Oxidative stress in stomach cancer
- Introduction
- Oxidative stress and host cell
- Oxidative stress and H. pylori
- Host damage by oxidative stress and gastric carcinogenesis
- Oxidative stress and CD44v9-positive gastric cancer stem cells