TAM receptors in health and disease /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Davra, Viralkumar, Galluzzi, Lorenzo
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2020.
Colección:International review of cell and molecular biology ; v. 357.
Temas:
Cell receptors > Health aspects.
Amines in the body.
Amines dans l'organisme.
Amines in the body
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • TAM Receptors in Health and Disease
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Recent advancements in role of TAM receptors on efferocytosis, viral infection, autoimmunity, and tissue repair
  • 1. Introduction
  • 2. Discovery of TAM receptors
  • 3. Overview of TAM receptors signaling
  • 4. Role of TAM receptors in viral infections
  • 5. Implication of TAM receptors in efferotyosis of ``DEAD�� cells
  • 6. New understanding of TAM receptors in autoimmunity
  • 7. Tissue repair emerges as a newly defined function of TAM receptors
  • References
  • Chapter Two: TAM receptors and their ligand-mediated activation: Role in atherosclerosis
  • 1. Introduction
  • 2. Defective efferocytosis and inflammation resolution in atherosclerosis
  • 2.1. Defective efferocytosis in atherosclerosis
  • 2.2. Defective inflammation resolution in atherosclerosis
  • 2.3. MerTK-mediated efferocytosis and inflammation resolution
  • 2.4. MerTK cleavage by ADAM17
  • 3. Conclusions and future directions
  • Acknowledgments
  • References
  • Chapter Three: Post-translational modifications of the ligands: Requirement for TAM receptor activation
  • 1. Overview of TAM receptors
  • 2. TAM receptors� biological functions
  • 2.1. Efferocytosis
  • 2.2. Regulation of innate immune response
  • 2.3. Promoting cancer development
  • 3. Ligand proteins for TAM receptors
  • 4. Post-translational modifications regulate Gas6/Pros1 activity
  • 5. Phosphatidylserine (PtdSer) and the mechanisms of PtdSer externalization
  • 6. Concluding remarks
  • References
  • Chapter Four: Immunological role of TAM receptors in the cancer microenvironment
  • 1. Introduction
  • 2. Oncogenic functions of TAM receptors
  • 3. Immune regulation in the tumor microenvironment
  • 4. Role of TAM receptors in the innate immunity
  • 5. Role of TAM receptors in the adaptive immunity
  • 6. Role of TAM receptors in the tumor microenvironment
  • 7. Role of TAM receptor ligands in cancer
  • 8. Targeting TAM receptors in cancer
  • 8.1. Classical small molecule tyrosine kinase inhibitors
  • 8.2. Antagonistic therapeutic antibodies
  • 8.3. Ligand targeted blockade: Soluble ectodomain receptors, a.k.a. ``decoy receptors,�� and Vitamin-K antagonists
  • 9. Concluding remarks and summary
  • References
  • Chapter Five: TAM receptors: A phosphatidylserine receptor family and its implications in viral infections
  • 1. Introduction
  • 1.1. Phosphatidylserine
  • 1.2. TAM receptor family
  • 2. TAM receptors in viral infection
  • 2.1. Negative-sense ssRNA viruses
  • 2.1.1. Mononegavirales (order)
  • 2.1.1.1. Filoviridae (family)
  • 2.1.1.1.1. Ebola and Marburg
  • 2.1.1.2. Pneumoviridae (family)
  • 2.1.1.2.1. Human orthopneumovirus (Respiratory syncytial virus/RSV)
  • 2.1.1.3. Rhabdoviridae (family)
  • 2.1.1.3.1. Vesicular stomatitis virus (VSV)
  • 2.1.2. Articulavirales (order)

Ejemplares similares