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Clinical bioenergetics : from pathophysiology to clinical translation /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
[2020]
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Acknowledgments
- Part I. Foundational aspects of bioenergetics and disease
- Chapter 1. Tissue specificity of energy metabolism in mitochondria
- Introduction
- Energetic metabolic profile of tissues and cell types
- Mitochondrial heterogeneity and tissue-specific properties of mitochondria
- Regulation of mitochondrial biogenesis and degradation
- Conclusions and perspectives
- Chapter 2. Impaired mitochondrial bioenergetics and signaling pathways: an overview
- Introduction
- Mitochondria-structure and functions
- Electron transport chain
- Mitochondrial bioenergetics
- Signaling pathways
- Impaired mitochondrial bioenergetics and signaling pathways
- Conclusion and future perspectives
- Part II. Disease-specific case studies
- Chapter 3. Abnormal mitochondrial metabolism in obesity and insulin resistance
- Introduction
- Abnormal mitochondrial metabolism in obesity and insulin resistance
- Conclusion
- Chapter 4. Impaired mitochondrial energy metabolism: etiologies and implications in neurodegenerative disease
- Introduction
- Mitochondrial bioenergetics measurement parameters
- Mechanisms of impaired mitochondrial metabolism
- Intrinsic factors
- Ca++ imbalance
- Intracellular reactive oxygen species
- Extrinsic factors
- Impaired mitochondrial metabolism and neurodegenerative disease
- Conclusions
- Chapter 5. Mitochondrial dysfunction in kidney diseases
- Key points
- Introduction
- Conclusion and perspective
- Conflict of interest
- Chapter 6. Mitochondrial role in NAFLD as a chronic disease
- Nonalcoholic fatty liver disease essentials
- Nonalcoholic fatty liver disease lipid overload: mitochondrial status
- Mitochondrial dysfunction
- Mitochondrial dynamics
- Mitochondrial DNA, role in nonalcoholic fatty liver disease
- Conclusion remarks
- Chapter 7. Decreased bioenergetics in traumatic brain injury
- Introduction
- Classifications and diagnosis of traumatic brain injury
- Oxidative stress and traumatic brain injury
- Traumatic brain injury and dementia
- Traumatic brain injury and its correlation to aggression
- Traumatic brain injury and posttraumatic stress disorder
- Concussive brain injuries
- Reduced energy metabolism associated with mild and moderate traumatic brain injury
- Glutamate excitotoxicity and traumatic brain injury
- Calcium and traumatic brain injury
- Reduced energetics associated with severe traumatic brain injury
- Inner mitochondrial membrane
- Peripheral dysfunction associated with traumatic brain injury
- Treatment strategies for traumatic brain injury
- Conclusions
- Chapter 8. Impaired mitochondrial bioenergetics in psychiatric disorders
- Introduction