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Developmental human behavioral epigenetics : principles, methods, evidence, and future directions /
Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the fiel...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2020.
|
| Colección: | Translational epigenetics ;
23 |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions
- Copyright
- Contents
- Contributors
- Keeping complexity in mind
- References
- Section I: Introduction
- Chapter 1: Principles of epigenetics and DNA methylation
- Definition of epigenetics
- Types of epigenetic modifications
- DNA cytosine methylation
- DNA cytosine hydroxymethylation
- DNA adenosine methylation
- RNA modifications
- Histone modifications
- RNAs
- Environmental effects, cell metabolism and epigenetics
- Epigenetic memory
- Environmental effects
- Cell metabolism, diet and microbiota
- Methods for methylation analysis
- Chromatin immunoprecipitation
- Nucleosome positioning
- DNA cytosine methylation analysis
- Locus-specific DNA methylation analysis
- Whole methylome analysis
- Selected genome-wide methylation analysis
- Epigenotyping arrays
- Direct readout of DNA methylation
- DNA methylation analysis of cell-free circulating DNA
- Single-cell epigenomics
- References
- Chapter 2: From animal to human epigenetics
- A rat story: Behavioral epigenetics beginnings
- Post-natal maternal environment shapes the epigenome and adult behavioral phenotypes of the offspring
- Environmental stimuli delivered to parents trigger processes to transmit information to offspring
- Permissive environments
- Environmental enrichment
- Maternal enrichment during pregnancy and/or lactation
- Pre-reproductive parental enrichment
- Aversive environments
- Aversive environment: Animal studies
- Epigenetic perturbation can be passed along
- Combining human and non-human animal research
- References
- Chapter 3: An overview of developmental behavioral genetics
- Background/history
- Behavioral genetic methodology
- Key interpretative issues
- Key results from twin and adoption studies
- Gene-environment interplay
- Gene-environment correlation
- Passive rGE
- Active rGE
- Evocative rGE
- Gene-environment interaction
- Genomic approaches to behavioral genetics
- Concluding remarks
- References
- Section II: Behavioral epigenetics in action
- Chapter 4: Prenatal exposures and behavioral epigenetics in human infants and children
- Early environmental programming
- Biological embedding
- Fetal DNA methylation after exposure to prenatal stress
- Does DNA methylation at birth predict postnatal outcomes?
- Further directions
- References
- Chapter 5: Applying behavioral epigenetic principles to preterm birth and early stress exposure
- Introduction
- Background
- Epigenetic regulation by early adverse experiences
- Epigenetic regulation by early protective experiences
- Preterm birth and NICU-related early adverse experiences
- Preterm birth and NICU-related early protective experiences
- A rationale for preterm behavioral epigenetics
- State of the art of PBE research