Actin cytoskeleton in cancer progression and metastasis. Part B /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Thomas, Cl�ement, Galluzzi, Lorenzo
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2020.
Colección:International review of cell and molecular biology ; v. 356.
Temas:
Actin.
Cytoskeleton.
Cancer > Molecular aspects.
Actins
Cytoskeleton
Actine.
Cytosquelette.
Cancer > Aspect mol�eculaire.
Actin
Cancer > Molecular aspects
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Actin Cytoskeleton in Cancer Progression and Metastasis
  • Part B
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Two sides of the coin: Cytoskeletal regulation of immune synapses in cancer and primary immune deficiencies
  • 1. Immune cells on the move-Requirement for actin cytoskeleton dynamics
  • 1.1. Seeding de novo actin filaments
  • 1.2. Nucleation promoting factors
  • 1.3. Regulation of actin filaments by Rho GTPases
  • 1.4. Actin polymerization in immune cells
  • 2. Actin in cell-cell contacts: Immunological synapses
  • 2.1. Cytolytic control of malignant transformation
  • 2.1.1. The cytolytic immunological synapse
  • 2.1.2. Receptor triggering
  • 2.1.2.1. T cells
  • 2.1.2.2. Natural Killer cells
  • 2.1.3. Lytic granule convergence
  • 2.1.4. Repositioing the microtubule-organizing centre
  • 2.1.5. Lytic granule exocytosis
  • 2.2. B cells: Gathering and endocytosis of antigen
  • 2.3. Dendritic cell synapses and cross-presentation
  • 2.4. Integrins at immunological synapses
  • 3. Primary immunodeficiency diseases reveal the critical role of actin regulators in immune cells
  • 3.1. Signal transduction via Rho GTPas: Regulatory mechanisms
  • 3.1.1. Rho guanine-nucleotide exchange factor 1 (ARHGEF1)
  • 3.1.2. Ras homolog family member A (RhoA)
  • 3.1.3. Ras-related C3 botulinum toxin substrate (Rac)
  • 3.1.3.1. Rac2
  • 3.1.3.2. Rac1
  • 3.1.4. Cell division control protein 42 homologue (CDC42)
  • 3.1.5. Atypical Rho GTPases
  • 3.1.5.1. Ras homologue family member H (RhoH)
  • 3.1.5.2. Ras homology growth-related (RhoG)
  • 3.1.6. Dedicator of cytokinesis (DOCK) family of proteins
  • 3.1.6.1. DOCK2
  • 3.1.6.2. DOCK8
  • 3.1.6.3. RAS Guanyl releasing protein 1 (RASGRP1)
  • 3.8. Actin nucleation: Actin-related protein 2/3 complex subunit 1B (ARPC1B)
  • 4. Actin in cell transformation
  • 4.1. Cell transformation: The role of actin in the nucleus
  • 4.2. Cellular rigidity or stiffness: Targeting the cell cytoskeleton
  • 5. Clinical relevance and therapy
  • Acknowledgments
  • References
  • Chapter Two: Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasio ...
  • 1. Introduction
  • 2. Actin cytoskeleton remodeling in mounting tumor resistance to cytotoxic lymphocytes

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