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SCIDIR_on1197074839 |
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OCoLC |
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20231120010510.0 |
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m o d |
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cr cnu---unuuu |
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200923s2020 mau o 001 0 eng d |
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|a OPELS
|b eng
|e rda
|e pn
|c OPELS
|d YDX
|d EBLCP
|d OCLCF
|d OCLCQ
|d OCLCO
|d OCLCQ
|d OCLCO
|d GZM
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| 019 |
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|a 1197544003
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| 020 |
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|a 9780128200032
|q (electronic bk.)
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| 020 |
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|a 0128200030
|q (electronic bk.)
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|z 9780128200025
|q (print)
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|z 0128200022
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| 035 |
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|a (OCoLC)1197074839
|z (OCoLC)1197544003
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| 050 |
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4 |
|a QR201.P737
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| 082 |
0 |
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|a 579.2/9
|2 23
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| 245 |
0 |
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|a Prions and neurodegenerative diseases /
|c edited by Giuseppe Legname.
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| 264 |
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1 |
|a Cambridge, MA :
|b Academic Press,
|c 2020.
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| 300 |
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|a 1 online resource (380 pages).
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Progress in molecular biology and translational science ;
|v volume 175
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| 500 |
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|a Includes index.
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| 588 |
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|a Description based on online resource; title from PDF title page (ScienceDirect, viewed September 23, 2020).
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|a Intro -- Prions and Neurodegenerative Diseases -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Clinical diagnosis of human prion disease -- 1. Introduction -- 2. The diagnostic problem -- 3. The non-specific supportive tests -- 3.1. The EEG -- 3.2. Brain MRI -- 3.3. CSF protein tests -- 3.4. Test combinations -- 4. Specific tests: Detection of abnormal prion protein -- 4.1. Capture/concentration techniques -- 4.2. The development of protein ``amplification�� techniques -- 5. Current routine clinical practice -- 5.1. Brain biopsy -- 5.2. PRNP analysis -- 5.3. Tonsil biopsy
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| 505 |
8 |
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|a 5.4. CSF RT-QuIC -- 6. Other tests -- 6.1. Skin biopsy -- 6.2. Nasal brushing/swabbing -- 6.3. Urine tests -- 6.4. Blood tests -- 7. Concluding comments -- References -- Chapter Two: Understanding prion structure and conversion -- 1. Introduction -- 2. Structural analyses of infectious and non-infectious PrP aggregates -- 3. Low-resolution approaches to study the structure of infectious prions -- 4. Attempts to solve the structure of infectious prions at high-resolution -- 5. Evolution of computational models for prion structure and conversion -- 6. Conclusions -- Acknowledgments -- References
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| 505 |
8 |
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|a Chapter Three: Role of sialylation in prion disease pathogenesis and prion structure -- 1. Introduction -- 2. Diversity of N-glycans in PrPC and PrPSc -- 3. N-glycan are exposed on a surface of PrPSc -- 4. Sialylation status of PrPSc and prion infectivity -- 5. Sialylation of PrPSc and lymphotropism -- 6. Animal-to-human prion transmission -- 7. Sialylation of PrPSc and neuroinflammation -- 8. Structural constraints imposed by N-glycans -- 9. Selective recruitment of PrPc sialoglycoforms and strain-specific structure -- 10. Role of sialic acid residues and prion replication
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| 505 |
8 |
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|a 11. Sialylation and strain interference -- 12. Concluding remarks -- References -- Chapter Four: Cofactor molecules: Essential partners for infectious prions -- 1. Introduction -- 2. Prion formation in vitro -- 3. Isolation and identification of endogenous prion cofactors -- 4. Cofactor molecules are required for the formation of infectious prions -- 5. Cofactor molecules restrict the strain properties of purified prions -- 6. Restoration of specific infectivity and strain properties from protein-only PrPSc -- 7. Cofactor selection model of neurotropism.
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| 650 |
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0 |
|a Prions.
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| 650 |
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0 |
|a Nervous system
|x Degeneration.
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| 650 |
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6 |
|a Prions (Virologie)
|0 (CaQQLa)201-0082917
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| 650 |
|
7 |
|a Nervous system
|x Degeneration
|2 fast
|0 (OCoLC)fst01036090
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| 650 |
|
7 |
|a Prions
|2 fast
|0 (OCoLC)fst01076986
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| 700 |
1 |
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|a Legname, Giuseppe,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Prions and neurodegenerative diseases.
|d Cambridge, MA : Academic Press, 2020
|z 0128200022
|z 9780128200025
|w (OCoLC)1133128055
|
| 830 |
|
0 |
|a Progress in molecular biology and translational science ;
|v v. 175.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/18771173/175
|z Texto completo
|
