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200923s2020 xx o 000 0 eng d |
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|a OPELS
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|a 019898535
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|a 1202932102
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|a 9780128177631
|q (ePub ebook)
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|a 0128177632
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|z 9780128177624
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|a (OCoLC)1197071800
|z (OCoLC)1202932102
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|a QP601
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|a 572/.7
|2 23
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|a Enzymes -- mechanisms, dynamics and inhibition /
|c edited by Tatyana Karabencheva-Christova, Christo Christov.
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|a [Place of publication not identified] :
|b Academic Press,
|c 2020.
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
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|a Advances in protein chemistry and structural biology ;
|v volume 122
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|a Title details screen.
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|a Front Cover -- Advances in Protein Chemistry and Structural Biology -- Enzymes -- Mechanisms, Dynamics and Inhibition -- Copyright -- Contents -- Contributors -- One -- Mapping enzyme-substrate interactions: its potential to study the mechanism of enzymes -- 1. Why modeling enzyme structure and dynamics -- 2. A method for everybody -- 2.1 Sequence-based approaches -- 2.2 Structure-based approaches -- 2.2.1 Molecular modeling -- 2.3 AI-based approaches -- 3. Enzymes mechanism: the potential of mapping enzyme-substrate interactions -- 4. From modeling to engineering -- References
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|a Two -- Experimental insight into enzyme catalysis and dynamics: A review on applications of state of art spectroscop ... -- 1. Introduction -- 2. Single molecule detection -- 2.1 Fluorescence correlation spectroscopy -- 2.2 Single molecule F�orster Resonance Energy Transfer -- 3. Ultrafast spectroscopy -- 4. Raman and Resonance Raman spectroscopy -- 5. Conclusion -- References -- Three -- Structure, catalytic mechanism, posttranslational lysine carbamylation, and inhibition of dihydropyrimidinases -- 1. Introduction -- 2. Structural mechanisms of Lys carbamylation in dihydropyrimidinase
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|a 3. Molecular basis of dimer or tetramer formation: different contact residues -- 4. Catalytic mechanism: dynamic loops, tunnel bottleneck, and metal content of dihydropyrimidinases -- 5. Competitive inhibitors of dihydropyrimidinase -- 6. Conclusions -- Acknowledgements -- References -- Four -- Catalytic activity regulation through post-translational modification: the expanding universe of protein div ... -- 1. Introduction -- 2. Post-translational modifications at protein backbones -- 2.1 A backbone proline hydroxylation promotes active-site maturation
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|a 2.2 Asparagine deamidation to isoAspartate impairs binding interactions with ligand -- 3. Metabolism regulation by post-translational modifications -- 3.1 Multiple post-translational modifications in a single active site -- 3.2 Lysine acylations: novel discoveries of PTMs of a commonly modified residue -- 4. AMPylation: new insights to an emerging modification -- 4.1 AMPylation regulates protein folding -- 4.2 AMPylation mediates bacterial pathogenicity and host-defense mechanisms -- 4.3 The SelO pseudokinase is actually an AMPylase
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|a 5. Stress responsive post-translational modifications: cysteine oxidation and S-nitrosylation -- 6. Conclusions -- References -- Five -- Current advances on the development of BET inhibitors: insights from computational methods -- 1. Introduction -- 2. In silico methods and computer-aided drug design (CADD) -- 2.1 Structure-based drug design (SBDD) -- 2.1.1 Molecular docking -- 2.1.2 Molecular dynamics (MD) -- 2.1.3 Free energy calculations -- 2.1.3.1 Scoring functions -- 2.1.3.2 End-point calculations -- 2.1.3.3 Free energy perturbations (alchemical methods) -- 2.1.4 Similarity methods
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|a Enzymes.
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|a Enzymes
|0 (DNLM)D004798
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|a Enzymes.
|0 (CaQQLa)201-0002557
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|a enzyme.
|2 aat
|0 (CStmoGRI)aat300212647
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|a Enzymes
|2 fast
|0 (OCoLC)fst00913605
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|a Christov, Christo
|c (Senior lecturer in computational biochemistry),
|e editor.
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|a Karabencheva-Christova, Tatyana,
|e editor.
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|i Print version :
|z 9780128177624
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|a Advances in protein chemistry and structural biology ;
|v v. 122.
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|u https://sciencedirect.uam.elogim.com/science/bookseries/18761623/122
|z Texto completo
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