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Ph-interfering agents as chemosensitizers in cancer therapy /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
[2021]
|
| Colección: | Cancer sensitizing agents for chemotherapy ;
10. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- pH-Interfering Agents as Chemosensitizers in Cancer Therapy
- Copyright
- Cover Image Insert
- Aims and scope for series``Cancer sensitizing agents for chemotherapy��
- About the Series Editor
- Aims and Scope of the Volume
- About the Volume Editors
- Preface
- Contents
- Contributors
- Part I: General overview of the topic: An update
- Chapter 1: Tumors and their microenvironment
- Introduction
- The role of tumor microenvironment
- Cancer-associated fibroblasts (CAFs)
- Angiogenic vascular cells
- Immune infiltrating cells
- ECM within the microenvironment
- Hypoxia and acidity
- References
- Chapter 2: pH regulators of the tumoral microenvironment: A general overview
- Introduction
- MCT1 and MCT4
- Carbonic anhydrases
- NHE1
- Sodium bicarbonate cotransporters and anion exchangers
- pH metabolons
- Effect of inhibiting pH regulators on migration, invasion, and metastasis
- Effect of inhibiting pH regulation on response to chemotherapy
- pH and mitochondria
- Conclusions
- References
- Chapter 3: Use of pH-interfering agents as chemosensitizers: Clinical studies survey
- Carbonic anhydrases
- Proton pump inhibitors
- Monocarboxylate transporters
- Ionophores
- Other pH-interfering agents
- Conclusion
- Acknowledgments
- References
- Part II: pH-Interfering agents as chemosensitizers
- Chapter 4: Proton pump inhibitors and other pH-buffering agents
- Introduction
- Tumor acidity and chemoresistance
- V-ATPases and proton pump inhibitors
- Preclinical data supporting the use of proton pump inhibitors in cancer treatment
- Clinical outcomes of proton pump inhibitors in association to anticancer therapies
- Monocarboxylate transporter (MCT) inhibitors
- Inhibitors of Na+/H+ exchanger (NHE), Na+/HCO3- cotransporter (NBC), and anion exchanger (AE)
- Conclusions
- References
- Chapter 5: Design, synthesis, and biological evaluation of selective hCA IX inhibitors
- Introduction
- Antibodies and antibody fragments which target CA IX
- Small molecules which target CA IX
- Conclusion
- References
- Chapter 6: Small molecules and monoclonal antibodies as selective hCA XII inhibitors: An update
- Introduction
- Small molecules and monoclonal antibodies as selective hCA XII inhibitors
- Differences in the active site of hCA IX and XII
- Recent sulfonamide derivatives as (selective) hCA XII inhibitors
- Coumarins and their derivatives as hCA XII inhibitors
- Drug repurposing and polypharmacology as innovative approaches to discover selective hCA XII inhibitors
- Monoclonal antibodies as very selective hCA XII inhibitors
- Conclusion
- References
- Chapter 7: Efflux pumps, NHE1, monocarboxylate transporters, and ABC transporter subfamily inhibitors
- Introduction
- Classes of transporters and efflux pumps
- Solute carrier class (SLC) transporters
- Monocarboxylate transporters
- MCT expression in normal tissues