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|a 1196193458
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|q (electronic bk.)
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|z 9780128207017
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|a (OCoLC)1193331097
|z (OCoLC)1195467314
|z (OCoLC)1196193458
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| 050 |
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|a RC271.C5
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| 082 |
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|a 616.994061
|2 23
|
| 245 |
0 |
0 |
|a Ph-interfering agents as chemosensitizers in cancer therapy /
|c edited by Claudiu T. Supuran and Simone Carradori.
|
| 260 |
|
|
|a London :
|b Academic Press,
|c [2021]
|
| 300 |
|
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|a 1 online resource
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Cancer sensitizing agents for chemotherapy ;
|v 10
|
| 505 |
0 |
|
|a Intro -- pH-Interfering Agents as Chemosensitizers in Cancer Therapy -- Copyright -- Cover Image Insert -- Aims and scope for series``Cancer sensitizing agents for chemotherapy�� -- About the Series Editor -- Aims and Scope of the Volume -- About the Volume Editors -- Preface -- Contents -- Contributors -- Part I: General overview of the topic: An update -- Chapter 1: Tumors and their microenvironment -- Introduction -- The role of tumor microenvironment -- Cancer-associated fibroblasts (CAFs) -- Angiogenic vascular cells -- Immune infiltrating cells -- ECM within the microenvironment
|
| 505 |
8 |
|
|a Hypoxia and acidity -- References -- Chapter 2: pH regulators of the tumoral microenvironment: A general overview -- Introduction -- MCT1 and MCT4 -- Carbonic anhydrases -- NHE1 -- Sodium bicarbonate cotransporters and anion exchangers -- pH metabolons -- Effect of inhibiting pH regulators on migration, invasion, and metastasis -- Effect of inhibiting pH regulation on response to chemotherapy -- pH and mitochondria -- Conclusions -- References -- Chapter 3: Use of pH-interfering agents as chemosensitizers: Clinical studies survey -- Carbonic anhydrases -- Proton pump inhibitors
|
| 505 |
8 |
|
|a Monocarboxylate transporters -- Ionophores -- Other pH-interfering agents -- Conclusion -- Acknowledgments -- References -- Part II: pH-Interfering agents as chemosensitizers -- Chapter 4: Proton pump inhibitors and other pH-buffering agents -- Introduction -- Tumor acidity and chemoresistance -- V-ATPases and proton pump inhibitors -- Preclinical data supporting the use of proton pump inhibitors in cancer treatment -- Clinical outcomes of proton pump inhibitors in association to anticancer therapies -- Monocarboxylate transporter (MCT) inhibitors
|
| 505 |
8 |
|
|a Inhibitors of Na+/H+ exchanger (NHE), Na+/HCO3- cotransporter (NBC), and anion exchanger (AE) -- Conclusions -- References -- Chapter 5: Design, synthesis, and biological evaluation of selective hCA IX inhibitors -- Introduction -- Antibodies and antibody fragments which target CA IX -- Small molecules which target CA IX -- Conclusion -- References -- Chapter 6: Small molecules and monoclonal antibodies as selective hCA XII inhibitors: An update -- Introduction -- Small molecules and monoclonal antibodies as selective hCA XII inhibitors -- Differences in the active site of hCA IX and XII
|
| 505 |
8 |
|
|a Recent sulfonamide derivatives as (selective) hCA XII inhibitors -- Coumarins and their derivatives as hCA XII inhibitors -- Drug repurposing and polypharmacology as innovative approaches to discover selective hCA XII inhibitors -- Monoclonal antibodies as very selective hCA XII inhibitors -- Conclusion -- References -- Chapter 7: Efflux pumps, NHE1, monocarboxylate transporters, and ABC transporter subfamily inhibitors -- Introduction -- Classes of transporters and efflux pumps -- Solute carrier class (SLC) transporters -- Monocarboxylate transporters -- MCT expression in normal tissues
|
| 650 |
|
0 |
|a Cancer
|x Chemotherapy.
|
| 650 |
|
0 |
|a Cancer
|x Treatment
|x Technological innovations.
|
| 650 |
|
0 |
|a Oncology.
|
| 650 |
1 |
2 |
|a Medical Oncology
|0 (DNLM)D008495
|
| 650 |
1 |
2 |
|a Neoplasms
|0 (DNLM)D009369
|
| 650 |
1 |
2 |
|a Neoplasms
|x drug therapy
|0 (DNLM)D009369Q000188
|
| 650 |
|
6 |
|a Cancer
|x Chimioth�erapie.
|0 (CaQQLa)201-0004691
|
| 650 |
|
6 |
|a Canc�erologie.
|0 (CaQQLa)201-0014055
|
| 650 |
|
7 |
|a Oncology
|2 fast
|0 (OCoLC)fst01045739
|
| 650 |
|
7 |
|a Cancer
|x Chemotherapy
|2 fast
|0 (OCoLC)fst00845327
|
| 650 |
|
7 |
|a Cancer
|x Treatment
|x Technological innovations
|2 fast
|0 (OCoLC)fst00845556
|
| 655 |
|
4 |
|a Internet Resources.
|
| 655 |
|
4 |
|a Index not Present.
|
| 700 |
1 |
|
|a Supuran, Claudiu T.
|
| 700 |
1 |
|
|a Carradori, Simone.
|
| 776 |
0 |
8 |
|i Print version:
|t Ph-interfering agents as chemosensitizers in cancer therapy.
|d London : Academic Press, [2021]
|z 0128207019
|z 9780128207017
|w (OCoLC)1135670406
|
| 830 |
|
0 |
|a Cancer sensitizing agents for chemotherapy ;
|v 10.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128207017
|z Texto completo
|
