Actin cytoskeleton in cancer progression and metastasis. Part A /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Thomas, Cl�ement, Galluzzi, Lorenzo
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2020.
Colección:International review of cell and molecular biology ; v. 355.
Temas:
Actin.
Cytoskeleton.
Cancer > Molecular aspects.
Actins
Cytoskeleton
Actine.
Cytosquelette.
Cancer > Aspect mol�eculaire.
Actin
Cancer > Molecular aspects
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Actin Cytoskeleton in Cancer Progression and Metastasis
  • Part A
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion
  • 1. Introduction
  • 2. The paxillin family
  • 3. Fundamentals of cell migration
  • 4. Roles of paxillin and Hic-5 in regulating migration and invasion
  • 4.1. Actin cytoskeleton-mediated effects
  • 4.1.1. Cell plasticity and 3D migration phenotypes
  • 4.1.2. Invadopodia and matrix degradation
  • 4.2. Crosstalk with microtubules
  • 4.3. Crosstalk with intermediate filaments
  • 4.4. Epithelial-mesenchymal transition
  • 5. Stroma-mediated effects on tumor invasion
  • 5.1. Extracellular matrix deposition
  • 5.2. Tumor neovascularization
  • 5.3. Immune cell function
  • 6. Regulation of gene expression
  • 6.1. Regulation of paxillin expression by miRNA
  • 6.2. Regulation of gene expression by Hic-5 and paxillin
  • 7. Paxillin family member mutations and expression in human cancers
  • 8. Therapeutic potential
  • 9. Conclusion
  • Funding
  • References
  • Chapter Two: Nuclear actin in cancer biology
  • 1. Historical perspective
  • 2. There and back again: How actin shuttles to and from the nucleus
  • 3. Now you see it, now you dont: The many faces of nuclear actin
  • 4. Nuclear actin: What it�s good for
  • 5. Nuclear actin and cancer: More than meets the eye?
  • References
  • Chapter Three: Nuclear actin and myosin in chromatin regulation and maintenance of genome integrity
  • 1. Introduction
  • 2. Evidence that actin, myosin and actin-related proteins are bona fide nuclear proteins
  • 3. Nuclear actin and myosin in transcriptional regulation
  • 4. Chromatin regulation by actin and myosin and the global transcriptional response
  • 5. Nuclear actin in transcriptional reprogramming during differentiation
  • 6. Potential role of nuclear actin and myosin in regulating the 3D genome: a future direction
  • 7. Evidence on the involvement of actin and myosin in genome integrity
  • 8. Actin- and myosin-dependent chromatin remodelers playing a role in genome integrity
  • 9. Actin and myosin as nuclear transporters to maintain genome integrity
  • 10. Actin and myosin in the transcriptional response to DNA damage
  • 11. Concluding remarks
  • Acknowledgments
  • References
  • Chapter Four: The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent i ...
  • 1. The actin cytoskeleton and actin-binding proteins
  • 2. Discovery of plastins
  • 3. The plastin family in humans
  • 4. L-plastin structure
  • 5. L-plastin activity regulation by Ca
  • 6. L-plastin functions: Impact of post-translational modification
  • 6.1. L-plastin primordial function: F-actin-binding and -bundling
  • 6.2. Associated functions of L-plastin
  • 6.2.1. During embryonic development
  • 6.2.2. Endocytosis

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