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|a 9780128212820
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|a Actin cytoskeleton in cancer progression and metastasis.
|n Part A /
|c edited by Cl�ement Thomas, Lorenzo Galluzzi.
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| 264 |
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1 |
|a Cambridge, MA :
|b Academic Press,
|c 2020.
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| 300 |
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
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|a International review of cell and molecular biology ;
|v v. 355
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|a Intro -- Actin Cytoskeleton in Cancer Progression and Metastasis -- Part A -- Copyright -- Contents -- Contributors -- Chapter One: Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion -- 1. Introduction -- 2. The paxillin family -- 3. Fundamentals of cell migration -- 4. Roles of paxillin and Hic-5 in regulating migration and invasion -- 4.1. Actin cytoskeleton-mediated effects -- 4.1.1. Cell plasticity and 3D migration phenotypes -- 4.1.2. Invadopodia and matrix degradation -- 4.2. Crosstalk with microtubules -- 4.3. Crosstalk with intermediate filaments
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|a 4.4. Epithelial-mesenchymal transition -- 5. Stroma-mediated effects on tumor invasion -- 5.1. Extracellular matrix deposition -- 5.2. Tumor neovascularization -- 5.3. Immune cell function -- 6. Regulation of gene expression -- 6.1. Regulation of paxillin expression by miRNA -- 6.2. Regulation of gene expression by Hic-5 and paxillin -- 7. Paxillin family member mutations and expression in human cancers -- 8. Therapeutic potential -- 9. Conclusion -- Funding -- References -- Chapter Two: Nuclear actin in cancer biology -- 1. Historical perspective
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|a 2. There and back again: How actin shuttles to and from the nucleus -- 3. Now you see it, now you dont: The many faces of nuclear actin -- 4. Nuclear actin: What it�s good for -- 5. Nuclear actin and cancer: More than meets the eye? -- References -- Chapter Three: Nuclear actin and myosin in chromatin regulation and maintenance of genome integrity -- 1. Introduction -- 2. Evidence that actin, myosin and actin-related proteins are bona fide nuclear proteins -- 3. Nuclear actin and myosin in transcriptional regulation
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|a 4. Chromatin regulation by actin and myosin and the global transcriptional response -- 5. Nuclear actin in transcriptional reprogramming during differentiation -- 6. Potential role of nuclear actin and myosin in regulating the 3D genome: a future direction -- 7. Evidence on the involvement of actin and myosin in genome integrity -- 8. Actin- and myosin-dependent chromatin remodelers playing a role in genome integrity -- 9. Actin and myosin as nuclear transporters to maintain genome integrity -- 10. Actin and myosin in the transcriptional response to DNA damage -- 11. Concluding remarks
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|a Acknowledgments -- References -- Chapter Four: The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent i ... -- 1. The actin cytoskeleton and actin-binding proteins -- 2. Discovery of plastins -- 3. The plastin family in humans -- 4. L-plastin structure -- 5. L-plastin activity regulation by Ca -- 6. L-plastin functions: Impact of post-translational modification -- 6.1. L-plastin primordial function: F-actin-binding and -bundling -- 6.2. Associated functions of L-plastin -- 6.2.1. During embryonic development -- 6.2.2. Endocytosis
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| 650 |
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0 |
|a Actin.
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| 650 |
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0 |
|a Cytoskeleton.
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| 650 |
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0 |
|a Cancer
|x Molecular aspects.
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| 650 |
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2 |
|a Actins
|0 (DNLM)D000199
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| 650 |
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2 |
|a Cytoskeleton
|0 (DNLM)D003599
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| 650 |
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6 |
|a Actine.
|0 (CaQQLa)201-0088526
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| 650 |
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6 |
|a Cytosquelette.
|0 (CaQQLa)201-0139323
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| 650 |
|
6 |
|a Cancer
|x Aspect mol�eculaire.
|0 (CaQQLa)201-0212614
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| 650 |
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7 |
|a Actin
|2 fast
|0 (OCoLC)fst00796140
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| 650 |
|
7 |
|a Cancer
|x Molecular aspects
|2 fast
|0 (OCoLC)fst00845397
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| 650 |
|
7 |
|a Cytoskeleton
|2 fast
|0 (OCoLC)fst00886325
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| 700 |
1 |
|
|a Thomas, Cl�ement.
|
| 700 |
1 |
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|a Galluzzi, Lorenzo.
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| 776 |
0 |
8 |
|i Print version:
|t Actin cytoskeleton in cancer progression and metastasis. Part A.
|d Cambridge, MA : Academic Press, 2020
|z 0128212810
|z 9780128212813
|w (OCoLC)1139946814
|
| 830 |
|
0 |
|a International review of cell and molecular biology ;
|v v. 355.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/19376448/355
|z Texto completo
|
