Annual reports in medicinal chemistry. Volume 54 /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Neidle, Stephen
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2020.
Colección:Issn Ser.
Temas:
Clinical chemistry.
Pharmaceutical chemistry.
Chemistry, Clinical
Chemistry, Pharmaceutical
Chimie clinique.
Chimie pharmaceutique.
Clinical chemistry
Pharmaceutical chemistry
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Foreword
  • References
  • Part 1: Fundamentals of quadruplexes and their biology
  • Chapter One: Fundamentals of G-quadruplex biology
  • 1. Introduction
  • 2. Experimental approaches to G-quadruplex biology
  • 2.1. Some general principles and potential pitfalls
  • 2.2. In silico approaches
  • 2.3. Antibodies
  • 2.4. Chromatin immunoprecipitation
  • 2.5. Small molecules
  • 2.6. Microscopy
  • 2.7. Genetic approaches
  • 3. Biological processes impacted by G-quadruplexes
  • 3.1. Chromatin
  • 3.2. Transcription
  • 3.3. Messenger RNAs
  • 3.4. Replication and genome stability
  • 3.5. Telomeres
  • 3.6. Mitochondria
  • 3.7. Cancer
  • 4. Closing remarks
  • Acknowledgments
  • References
  • Chapter Two: Quadruplex structure and diversity
  • 1. Structural elements of G-quadruplexes
  • 1.1. G-tetrads
  • 1.1.1. Individual component-G-tetrad configuration
  • 1.1.2. Relational component-G-tetrad stacking interaction
  • 1.1.3. Topological rules
  • 1.2. G-columns
  • 1.2.1. Individual component-G-column continuity
  • 1.2.2. Relational component-G-column relative directionality
  • 1.2.3. Topological rules
  • 1.3. Loops
  • 1.3.1. Individual component-Type of loops
  • 1.3.2. Relational component-Peripheral structures
  • 1.3.3. Topological rules
  • 2. DNA G-quadruplexes
  • 2.1. Canonical DNA G-quadruplexes
  • 2.1.1. Parallel
  • 2.1.2. Hybrid-Form 1 and form 2
  • 2.1.3. Anti-parallel-Chair and basket
  • 2.2. Non-canonical DNA G-quadruplexes
  • 2.2.1. Discontinuous G-columns
  • 2.2.2. Peripheral structures
  • 2.2.3. Left-handed G-column progressions
  • 3. RNA G-quadruplexes
  • 3.1. Canonical RNA G-quadruplex
  • 3.2. Non-canonical RNA G-quadruplexes
  • 3.2.1. FMRP-binding RNA aptamer
  • 3.2.2. Spinach RNA aptamer and its derivatives
  • 4. Conclusions
  • References
  • Part 2: Quadruplex targets in human and other organisms
  • Chapter Three: Telomeric quadruplexes as therapeutic targets
  • 1. Introduction
  • 2. Telomere maintenance mechanisms and cancer
  • 3. Structures of telomeric quadruplexes in vitro and in vivo
  • 4. Ligand-based targeting of telomeric quadruplexes toward cancer therapy
  • 5. Concluding remarks
  • Acknowledgments
  • References
  • Chapter Four: Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy
  • 1. Introduction
  • 2. DNA viruses
  • 2.1. Herpesviruses
  • 2.1.1. Alpha-herpesviruses
  • 2.1.2. Beta-herpesviruses
  • 2.1.2.1. Human cytomegalovirus
  • 2.1.2.2. Human herpesviruses 6A/6B
  • 2.1.3. Gamma-herpesviruses
  • 2.1.3.1. Epstein-Barr virus
  • 2.1.3.2. Kaposi�s sarcoma-associated herpesvirus
  • 2.2. Other DNA viruses
  • 2.2.1. Human papillomavirus
  • 2.2.2. Hepatitis B virus
  • 3. RNA viruses
  • 3.1. Flaviviruses
  • 3.1.1. ZIKA virus
  • 3.1.2. Hepatitis C virus
  • 3.2. Filoviruses
  • 3.3. SARS coronavirus
  • 4. Retroviruses
  • 4.1. Lentiviruses
  • 4.1.1. Human immunodeficiency virus type 1

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