Nanomaterials for theranostics and tissue engineering : techniques, trends and applications /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Rossi, Filippo, Rainer, Alberto
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Elsevier, 2020.
Colección:Micro & nano technologies.
Temas:
Nanostructured materials.
Nanomedicine.
Tissue engineering.
Nanostructures
Tissue Engineering
Nanomedicine
Nanomat�eriaux.
G�enie tissulaire.
Nanom�edecine.
Nanostructured materials
Tissue engineering
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Nanomaterials for Theranostics and Tissue Engineering
  • Copyright Page
  • Contents
  • List of contributors
  • Introduction
  • 1 Polymeric nanoparticles for controlled drug delivery
  • 1.1 General concepts and synthetic strategies
  • 1.2 Polymer nanoparticles for controlled drug delivery
  • 1.2.1 Stimuli-responsive polymer nanoparticles
  • 1.3 The long road from the bench to the clinic
  • 1.4 Conclusions
  • References
  • 2 Extracellular vesicles in regenerative medicine
  • 2.1 Introduction
  • 2.2 Cell-based therapies
  • 2.3 Tissue engineering
  • 2.4 Cell-free therapies
  • 2.4.1 Soluble factors
  • 2.4.2 Biogenic and synthetic nanoparticles
  • 2.5 Extracellular vesicles in a nutshell
  • 2.5.1 Extracellular vesicle biological and physicochemical properties
  • 2.5.2 Extracellular vesicle separation and characterization
  • 2.5.3 Medical translation of extracellular vesicles
  • 2.6 Regenerative properties of extracellular vesicles
  • 2.6.1 Why extracellular vesicles?
  • 2.6.2 Preclinical studies
  • 2.6.3 Clinical studies
  • 2.6.4 Limits of extracellular vesicle applications in clinical treatments
  • 2.7 Conclusions
  • Acknowledgments
  • References
  • 3 Novel strategies to improve delivery performances
  • 3.1 Introduction
  • 3.2 Functionalization strategies: the rationale
  • 3.2.1 Chemical routes
  • 3.2.1.1 Esterification and modification of active ester
  • 3.2.1.2 Click chemistry
  • 3.2.1.3 Other chemical cross-linking strategies
  • 3.2.2 Physical routes
  • 3.3 Applications in tissue engineering
  • 3.3.1 The cell membranes barrier
  • 3.3.2 The tumor environment
  • 3.3.3 The blood-brain barrier
  • 3.4 Applications in theranostics
  • 3.5 Conclusions
  • References
  • 4 HR-MAS NMR Spectroscopy: novel technologies to measure delivery performance
  • 4.1 Introduction
  • 4.2 High-resolution magic angle spinning nuclear magnetic resonance
  • 4.2.1 Theory
  • 4.2.2 Experimental setup
  • 4.2.3 Example HR-MAS resolution enhancement in hydrogel polymers and swollen polymers
  • 4.3 Pulse field gradient HR-MAS nuclear magnetic resonance spectroscopy
  • 4.3.1 Translational motion in isotropic systems
  • 4.3.2 Restricted and anisotropic motion
  • 4.4 Applications in drug delivery
  • 4.4.1 Cyclodextrin nanosponges polymers
  • 4.4.2 Agarose-carbomer copolymers hydrogels
  • 4.5 Final remarks
  • References
  • 5 The role of first principles mathematical modeling in the nanomedicine field
  • 5.1 The new challenges introduced by nanomedicine
  • 5.2 Modeling approaches
  • 5.2.1 An introduction to molecular modeling
  • 5.2.2 Molecular dynamics
  • 5.2.3 Coarse-grained simulations
  • 5.2.4 Enhanced sampling methods
  • 5.2.5 Macroscale models
  • 5.3 Applications of mathematical modeling in the nanomedicine field
  • 5.3.1 Biomolecular corona
  • 5.3.2 Targeting and cellular uptake
  • 5.3.3 Nanoparticle distribution and drug delivery
  • 5.4 Conclusions
  • References

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