Biomaterials for 3D tumor modeling /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Kundu, S. C. (Subhas Chandra), Reis, Rui L.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam, Netherlands : Elsevier, 2020.
Colección:Materials today
Temas:
Biomedical materials.
Three-dimensional imaging in medicine.
Tumors > Computer simulation.
Biomedical and Dental Materials
Biocompatible Materials
Imaging, Three-Dimensional
Biomat�eriaux.
Imagerie tridimensionnelle en m�edecine.
Tumeurs > Simulation par ordinateur.
Biomedical materials
Three-dimensional imaging in medicine
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Biomaterials for 3D Tumor Modeling
  • Copyright Page
  • Contents
  • List of Contributors
  • Preface
  • I. Engineering biomaterials for 3D cancer modelling
  • 1 Trends in biomaterials for three-dimensional cancer modeling
  • Abbreviations
  • 1.1 A historical introduction
  • 1.1.1 In vitro and in vivo models: an overview
  • 1.1.2 A paradigm shift
  • 1.1.3 Three-dimensional biomaterials for cancer modeling
  • 1.1.4 From the lab to the clinic
  • 1.2 The three-dimensional tumor microenvironment
  • 1.2.1 The tumor and its three-dimensional environment: a synergistic interaction
  • 1.2.2 Biomaterials as a model of the tumor niche
  • 1.2.2.1 Scaffold-based biomaterials
  • 1.2.2.2 Matrix-based
  • 1.2.2.3 Microcarrier-based
  • 1.2.2.4 Scaffold-free: tumor spheroids
  • 1.2.2.5 Microstructured surfaces
  • 1.3 Engineering the native tumor microenvironment using custom-designed three-dimensional biomaterials
  • 1.3.1 Tissue engineering approaches
  • 1.3.1.1 Freeze-drying
  • 1.3.1.2 Photopolymerization
  • 1.3.1.3 Three-dimensional bioprinting
  • 1.3.2 Nanotechnology approaches
  • 1.3.2.1 Molding
  • 1.3.2.2 Printing
  • 1.3.2.2.1 (Two-dimensional) microcontact printing
  • 1.3.2.2.2 Three-dimensional printing
  • 1.3.2.2.3 Four-dimensional printing
  • 1.4 Advanced models of the three-dimensional tumor microenvironment
  • 1.4.1 Microfluidics-based models
  • 1.4.1.1 Microfluidic-based models of tumors: tumor-on-a-chip
  • 1.4.1.2 Drug discovery and screening on-chip
  • 1.4.1.3 Reproducing dynamic events on-chip
  • 1.4.1.4 Personalized tumor-on-a-chip models
  • 1.4.1.5 Manufacturing methods of a tumor-on-a-chip
  • 1.4.2 Three-dimensional bioprinted models
  • 1.5 Applications of three-dimensional tumor models in cancer therapeutics
  • 1.5.1 Drug discovery, development, and screening
  • 1.5.2 Transport and delivery of drugs
  • 1.6 Limitations of biomaterials-based three-dimensional tumor models
  • 1.7 Future of three-dimensional biomaterials for cancer research
  • 1.8 Final remarks and conclusions
  • References
  • 2 Bioinspired biomaterials to develop cell-rich spherical microtissues for 3D in vitro tumor modeling
  • 2.1 Introduction
  • 2.2 Human Tumor microenvironment-key hallmarks to mimic in vitro
  • 2.3 3D In vitro tumor models-bridging the gap from 2D flat cultures to in vivo
  • 2.4 Classes of 3D multicellular tumor models
  • 2.4.1 Scaffold-free cell-rich 3D multicellular tumor spheroids
  • 2.4.2 Scaffold-based 3D multicellular tumor models
  • 2.4.2.1 Biomaterials for establishing physiomimetic 3D tumor microenvironments
  • 2.4.2.1.1 Natural and nature-derived biomaterials for 3D tumor modeling
  • Protein-based biomaterials
  • Polysaccharide-based biomaterials
  • 2.4.2.1.2 Synthetic biomaterials for 3D tumor modeling
  • 2.4.2.1.3 Hybrid biomaterials for 3D tumor modeling
  • 2.4.3 Generation of spherically structured cell-rich 3D tumor models
  • 2.4.3.1 Microparticles for spherically structured 3D tumor models assembly

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