Identification and quantification of drugs, metabolites, drug metabolizing /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Ma, Shuguang, Chowdhury, Swapan K.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Elsevier, 2020.
Temas:
Drugs > Analysis.
Drugs > Metabolism.
Metabolites.
Biochemical markers.
Pharmaceutical Preparations > analysis
Pharmaceutical Preparations > metabolism
Biomarkers
M�edicaments > Analyse.
M�edicaments > M�etabolisme.
M�etabolites.
Marqueurs biologiques.
Biochemical markers
Drugs > Analysis
Drugs > Metabolism
Metabolites
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters: Concepts, Methods, a ...
  • Copyright
  • Contents
  • Contributors
  • Foreword
  • References
  • Preface
  • Part I: Techniques for identifying and quantifying drugs and metabolites
  • Chapter 1: Bioanalysis of small and large molecule drugs, metabolites, and biomarkers by LC-MS
  • 1. Introduction
  • 2. Complexity of contemporary bioanalysis
  • 3. Bioanalytical requirements for supporting discovery, nonclinical, and clinical studies
  • 4. Current regulatory landscape for bioanalysis
  • 5. General considerations for bioanalysis for sample collection
  • 6. Diagnosis and mitigation of nonspecific adsorption loss for urine bioanalysis
  • 7. Tissue bioanalysis
  • 8. Managing unstable metabolites such as acyl glucuronide
  • 9. General considerations for bioanalysis for extraction, chromatography, and MS detection
  • 10. Selected applications for LC-MS bioanalysis
  • 10.1. LC-MS of large molecules
  • 10.1.1. LC-MS bioanalysis of mAb
  • 10.1.2. LC-MS bioanalysis of ADC
  • 10.1.3. LC-MS bioanalysis of PDC
  • 10.1.4. LC-MS bioanalysis of protein biomarkers
  • 10.3.3. Fatty acid amide hydrolase biomarkers (authentic matrix and surrogate analytes)
  • 10.4. LC-MS analysis of metabolites and MIST
  • 10.4.1. Metabolite quantitation strategy
  • 10.4.2. LC-MS bioanalysis of polar metabolites
  • 10.4.3. Bioanalysis of chiral compounds
  • 10.4.4. Unexpected assay challenge during analysis of patient samples
  • 11. Conclusion and future perspective
  • References
  • Chapter 2: Recent advances in mass spectrometric and other analytical techniques for the identification of drug metabolites
  • 1. Introduction
  • 2. Sample preparation strategies
  • 2.1. Solid-phase extraction
  • 2.2. Supported phase liquid extraction
  • 2.3. Liquid-liquid extraction
  • 2.4. Protein precipitation
  • 3. Optical detectors and chromatographic separation techniques
  • 3.1. Ultra-performance liquid chromatography
  • 3.2. Supercritical fluid chromatography
  • 4. Different types of Ionization techniques and mass spectrometric scan functions
  • 4.1. Ionization techniques
  • 4.2. Mass analyzers and different acquisition modes
  • 4.3. Inductively coupled mass spectrometry (ICP-MS)
  • 5. Wet chemistry techniques combined with MS

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