Novel therapies in head and neck cancer : beyond the horizon /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: St. John, Maie A., Park, No-Hee
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, 2020.
Colección:Cancer sensitizing agents for chemotherapy ; v. 9.
Temas:
Head > Cancer > Treatment.
Neck > Cancer > Treatment.
Head and Neck Neoplasms > therapy
Head > Cancer > Treatment
Neck > Cancer > Treatment
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Novel Therapies in Head and Neck Cancer: Beyond the Horizon
  • Copyright
  • Cover Image Legend
  • Aims and scope for series ``Cancer sensitizing agents for chemotherapy��
  • About the Series Editor
  • Aims and Scope of the Volume
  • About the Volume Editors
  • Maie A. St. John, M.D., Ph.D., FACS
  • No-Hee Park, D.M.D., Ph.D.
  • Preface
  • It takes a village
  • Contents
  • Contributors
  • Chapter 1: Introduction: Leaps and bounds
  • Conflict of interest
  • Introduction
  • Surgical innovation: TORS and TLM
  • Radiation therapy
  • Immunotherapy
  • Conclusion
  • References
  • Chapter 2: Chemotherapy: Where we have been and where we are going
  • Introduction
  • Chemotherapy in locally advanced SCCHN
  • Postoperative concurrent chemoradiotherapy
  • Definitive combined chemoradiotherapy
  • Definitive concurrent chemoradiotherapy (CCRT)
  • Induction chemotherapy
  • Sequential chemoradiotherapy
  • Systemic therapy for recurrent, unresectable, or metastatic disease
  • Nasopharyngeal cancer
  • Conclusion
  • References
  • Chapter 3: Targeted therapy: Precision comes to life
  • Introduction
  • Employing the precision medicine model for the management of head and neck squamous cell carcinoma
  • Targeting the epidermal growth factor receptor
  • Targeting the phosphoinositide 3-kinase-AKT-Mammalian target of rapamycin axis
  • Single agent and combinatorial approaches to targeting the cell cycle pathway
  • Precision medicine initiatives for the management of salivary gland carcinomas
  • Leveraging the epigenetic and immunogenic role of histone deacetylase inhibitors
  • Employing a multitargeted approach to tyrosine kinase inhibition
  • Concluding remarks
  • References
  • Chapter 4: Novel drug delivery systems for head and neck cancers: Beyond the horizon
  • Introduction
  • Polymer films
  • Hydrogels and scaffolds
  • Augmented radiation therapy and imaging
  • Microneedle patches
  • Nanoparticles
  • Immunomodulation
  • Conclusion
  • Acknowledgments
  • References
  • Chapter 5: HPV-positive oropharyngeal cancers: Today and tomorrow
  • Introduction
  • Epidemiology
  • Current staging
  • Treatment options and outcomes
  • Nonsurgical treatment options
  • Radiation therapy
  • Systemic therapy with radiation therapy
  • Surgical treatment options
  • Transoral robotic surgery (TORS)
  • Current status of deescalation strategies
  • Minimally invasive surgery
  • Replacing cisplatin with cetuximab
  • Induction chemotherapy followed by reduced radiotherapy dose
  • Immunotherapy
  • Preventive strategies
  • Ongoing and future research
  • Conclusions
  • References
  • Chapter 6: Treatment resistance and a glimmer of hope, the promise of new agents
  • Introduction
  • Treatment resistance: Defining the problem
  • Treatment resistance: Detecting the problem
  • Biology is destiny
  • Radiation resistance

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