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Camptothecin and camptothecin producing plants : botany, chemistry, anticancer activity and biotechnology /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Pullaiah, T.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, 2020.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Camptothecin and Camptothecin Producing Plants
  • Copyright Page
  • Contents
  • Preface
  • Abbreviations
  • 1 Cancer biology and other disorders: beneficial role of camptothecin and novel derivatives
  • 1.1 Introduction
  • 1.2 The principles underlying transformation of normal cells into tumor
  • 1.2.1 Self-sufficiency in growth signals
  • 1.2.2 Insensitivity to antigrowth signals
  • 1.2.3 Evading apoptosis
  • 1.2.4 Limitless Replicative potential
  • 1.2.5 Sustained angiogenesis
  • 1.2.6 Tissue invasion and metastasis
  • 1.3 Nuclear transcription factor kappa B
  • 1.6.1 Deregulation of the apoptotic machinery
  • 1.6.1.1 Expression of antiapoptotic proteins
  • 1.6.1.2 Inactivation of proapoptotic genes
  • 1.6.2 Drug influx and efflux
  • 1.6.3 Drug inactivation
  • 1.6.4 Drug targets
  • 1.6.5 Alterations of the p53 pathway
  • 1.6.6 DNA damage repair
  • 1.6.7 Alterations in the survival signaling
  • 1.6.8 Cell cycle events in context to antitumor agents
  • 1.7 Strategy to overcome chemoresistance
  • 1.7.1 Combination therapy
  • 1.8 Camptothecin
  • 1.8.1 Camptothecin and related derivatives-biological activity
  • 1.8.1.1 Antitumor activity
  • 1.8.1.2 Antiviral activity
  • 1.8.1.3 Pesticidal activity
  • 1.8.1.4 Antiparasitic activity
  • 1.8.1.5 Antipsoriasis activity
  • 1.8.1.6 Antifungal/antimicrobial activity
  • 1.8.1.7 Hypoxia-inducible factor inhibitory activity
  • 1.9 Conclusions
  • References
  • 2 Camptothecin: chemistry, biosynthesis, analogs, and chemical synthesis
  • 2.1 Introduction
  • 2.2 Chemistry of camptothecin
  • 2.3 A historical account on the discovery of camptothecin
  • 2.4 Plant sources of camptothecin
  • 2.5 Factors affecting camptothecin production in plants
  • 2.5.1 Nothopodytes
  • 2.5.1.1 Geographical factors affecting camptothecin synthesis
  • 2.5.1.2 Seasons
  • 2.5.1.3 Plant parts
  • 2.5.2 Ophiorrhiza
  • 2.6 Camptothecin from endophytes
  • 2.7 Biosynthetic pathway
  • 2.8 Extraction of camptothecin
  • 2.9 Clinically useful derivatives of camptothecin
  • 2.9.1 Topotecan (hycamtin)
  • 2.9.2 Irinotcan
  • 2.9.3 Etirinotecan pegol, a conjugate of irinotecan
  • 2.10 Analogs of camptothecin under clinical investigation
  • 2.10.1 Rubitecan
  • 2.10.2 Exatecan
  • 2.10.3 FL118, a novel structurally similar analog of camptothecin
  • 2.10.4 Gimatecan
  • 2.10.5 Morpholinocamptothecin