Camptothecin and camptothecin producing plants : botany, chemistry, anticancer activity and biotechnology /
Clasificación: | Libro Electrónico |
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Otros Autores: | |
Formato: | Electrónico eBook |
Idioma: | Inglés |
Publicado: |
London :
Academic Press,
2020.
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Temas: | |
Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover
- Camptothecin and Camptothecin Producing Plants
- Copyright Page
- Contents
- Preface
- Abbreviations
- 1 Cancer biology and other disorders: beneficial role of camptothecin and novel derivatives
- 1.1 Introduction
- 1.2 The principles underlying transformation of normal cells into tumor
- 1.2.1 Self-sufficiency in growth signals
- 1.2.2 Insensitivity to antigrowth signals
- 1.2.3 Evading apoptosis
- 1.2.4 Limitless Replicative potential
- 1.2.5 Sustained angiogenesis
- 1.2.6 Tissue invasion and metastasis
- 1.3 Nuclear transcription factor kappa B
- 1.6.1 Deregulation of the apoptotic machinery
- 1.6.1.1 Expression of antiapoptotic proteins
- 1.6.1.2 Inactivation of proapoptotic genes
- 1.6.2 Drug influx and efflux
- 1.6.3 Drug inactivation
- 1.6.4 Drug targets
- 1.6.5 Alterations of the p53 pathway
- 1.6.6 DNA damage repair
- 1.6.7 Alterations in the survival signaling
- 1.6.8 Cell cycle events in context to antitumor agents
- 1.7 Strategy to overcome chemoresistance
- 1.7.1 Combination therapy
- 1.8 Camptothecin
- 1.8.1 Camptothecin and related derivatives-biological activity
- 1.8.1.1 Antitumor activity
- 1.8.1.2 Antiviral activity
- 1.8.1.3 Pesticidal activity
- 1.8.1.4 Antiparasitic activity
- 1.8.1.5 Antipsoriasis activity
- 1.8.1.6 Antifungal/antimicrobial activity
- 1.8.1.7 Hypoxia-inducible factor inhibitory activity
- 1.9 Conclusions
- References
- 2 Camptothecin: chemistry, biosynthesis, analogs, and chemical synthesis
- 2.1 Introduction
- 2.2 Chemistry of camptothecin
- 2.3 A historical account on the discovery of camptothecin
- 2.4 Plant sources of camptothecin
- 2.5 Factors affecting camptothecin production in plants
- 2.5.1 Nothopodytes
- 2.5.1.1 Geographical factors affecting camptothecin synthesis
- 2.5.1.2 Seasons
- 2.5.1.3 Plant parts
- 2.5.2 Ophiorrhiza
- 2.6 Camptothecin from endophytes
- 2.7 Biosynthetic pathway
- 2.8 Extraction of camptothecin
- 2.9 Clinically useful derivatives of camptothecin
- 2.9.1 Topotecan (hycamtin)
- 2.9.2 Irinotcan
- 2.9.3 Etirinotecan pegol, a conjugate of irinotecan
- 2.10 Analogs of camptothecin under clinical investigation
- 2.10.1 Rubitecan
- 2.10.2 Exatecan
- 2.10.3 FL118, a novel structurally similar analog of camptothecin
- 2.10.4 Gimatecan
- 2.10.5 Morpholinocamptothecin