Novel therapeutic advances in glioblastoma /

"Novel Therapeutic Advances in Glioblastoma, Volume 151 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Blood-brain barrier and pathophysiology of brain tumors, Promi...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bryukhovetskiy, Igor (Editor ), Sharma, Aruna, MD (Editor ), Zhang, Zhiqiang (Editor ), Sharma, H. S. (Hari Shanker) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2020.
Colección:International review of neurobiology ; v. 151.
Temas:
Gliomas > Treatment > Technological innovations.
Gliomas.
Brain Neoplasms
Glioma
Gliome > Traitement > Innovations.
Gliome.
Gliomas
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Novel Therapeutic Advances in Glioblastoma
  • Copyright
  • Contents
  • Contributors
  • Preface
  • References
  • Acknowledgments
  • Chapter One: Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
  • 1. Introduction
  • 1.1. History of glioblastoma
  • 2. The blood-brain barrier and brain tumors
  • 2.1. The blood-brain barrier structure and function
  • 2.1.1. The BBB microenvironment
  • 2.1.2. Adsorptive mediated BBB transport
  • 2.1.3. Carrier mediated BBB transport
  • 2.1.4. Receptor mediated BBB transport
  • 2.1.5. The blood-brain barrier function in physiological conditions
  • 3. The blood-tumor barrier structure and function
  • 3.1. The blood-tumor barrier
  • 3.2. The blood-tumor barrier heterogeneity
  • 4. Therapeutic strategies for brain tumor
  • 4.1. Glioma stem cell and resistance and BT therapy
  • 4.1.1. Pathogenesis of glioblastoma
  • 4.2. Bacterial toxins and viral vectors for novel glioma therapy
  • 4.2.1. Viral infections and cancer
  • 4.2.2. Bacterial infection and cancer
  • 4.2.3. Viral genome modification and glioblastoma treatment
  • 4.2.4. Viral vectors and glioblastoma treatment
  • 4.3. Enhanced drug delivery through the blood-brain and blood-tumor barriers
  • 4.3.1. Modulation of influx transport at BTB/BBB
  • 4.3.2. Modulation of efflux transporters at BTB/BBB
  • 4.3.3. Stem cell induced drug delivery at the BTB/BBB
  • 5. Nano-drug delivery for brain tumor therapy
  • 5.1. Nanodelivery of drugs and enhanced permeability and retention
  • 5.1.1. Active tumor targeting by nanoparticles
  • 5.1.2. Nanoparticles for treating brain tumor stem cells
  • 5.1.3. Nanoparticles and glioma resistance factor
  • 6. Theranostic nanomedicine for brain tumor therapy
  • 6.1. Multifunctionalized nanoplatforms
  • 7. Our experiments with nanowired delivery of drugs in experimental glioma
  • 7.1. Induction of primary glioma
  • 7.1.1. Plasma biomarker of rat brain glioma
  • 7.1.2. Measurement of VEGF-121 in plasma of rat brain glioma
  • 7.1.3. Nanodelivery of drugs using TiO2 nanowires for rat glioma
  • 7.1.4. Nanodelivery of drugs reduces pathophysiology of rat brain glioma
  • 8. Possible mechanisms of nanowired drug delivery on neuroprotection in rat glioma
  • 9. Conclusion and future direction
  • Acknowledgments
  • References
  • Chapter Two: Personalized therapy and stem cell transplantation for pro-inflammatory modulation of cancer stem cells micr ...
  • 1. Introduction
  • 2. Modern standards for GBM treatment and reasons for their inefficiency
  • 3. BBB and treatment resistance
  • 4. Nano-based drug delivery
  • 5. Genotoxic pharmacotherapy and methods for optimization
  • 6. CSCs and personalized therapy
  • 7. Normal stem cells and treatment resistance
  • 8. CSCs and well-differentiated non-tumor cells in GBM

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